发明授权
US08026230B2 Methods and compositions for treating cancer using proteasome inhibitors
有权
使用蛋白酶体抑制剂治疗癌症的方法和组合物
- 专利标题： Methods and compositions for treating cancer using proteasome inhibitors
- 专利标题（中）： 使用蛋白酶体抑制剂治疗癌症的方法和组合物
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申请号： US11119473申请日： 2005-04-29
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公开(公告)号： US08026230B2公开(公告)日： 2011-09-27
- 发明人: Kenneth C. Anderson , Teru Hideshima , Constantine S. Mitsiades , Nicholas Mitsiades
- 申请人： Kenneth C. Anderson , Teru Hideshima , Constantine S. Mitsiades , Nicholas Mitsiades
- 申请人地址： US MA Boston
- 专利权人： Dana-Farber Cancer Institute, Inc.
- 当前专利权人： Dana-Farber Cancer Institute, Inc.
- 当前专利权人地址： US MA Boston
- 代理机构： Foley Hoag, LLP
- 主分类号： A61K38/08
- IPC分类号： A61K38/08 ; A61K38/05 ; A61K31/04
摘要：
The present invention relates to therapeutic compositions for treating cancer or preventing the growth of cancer cells, e.g., tumor growth, in a subject. The present invention also relates to methods for treating cancer, e.g., inhibiting tumor growth, in a subject who has become resistant to treatment, by administering to a subject an effective amount of a proteasome inhibitor and an effective amount of a therapeutic agent, e.g., a chemotherapeutic agent. The present invention further relates to methods for purging bone marrow, i.e., removing cancer cells from bone marrow, by exposing the bone marrow cells to a proteasome inhibitor and a therapeutic agent, e.g., a chemotherapeutic agent.
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