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11 条记录 (耗时 0.026 秒)

    Methods and Compositions for Treating Cancer Using Proteasome Inhibitors
    1.
    发明申请
    Methods and Compositions for Treating Cancer Using Proteasome Inhibitors 有权
    使用蛋白酶体抑制剂治疗癌症的方法和组合

    公开(公告)号：US20120214757A1

    公开(公告)日：2012-08-23

    申请号：US13242209

    申请日：2011-09-23

    申请人： Kenneth C. Anderson ,  Teru Hideshima ,  Constantine S. Mitsiades ,  Nicholas Mitsiades

    发明人： Kenneth C. Anderson ,  Teru Hideshima ,  Constantine S. Mitsiades ,  Nicholas Mitsiades

    IPC分类号： A61K31/69 ,  A61K31/197 ,  A61P35/00 ,  A61K31/704

    CPC分类号： A61K31/69 ,  A61K31/195 ,  A61K31/198 ,  A61K31/573 ,  A61K31/704 ,  A61K38/05 ,  A61K45/06 ,  A61K2300/00

    摘要： The present invention relates to therapeutic compositions for treating cancer or preventing the growth of cancer cells, e.g., tumor growth, in a subject. The present invention also relates to methods for treating cancer, e.g., inhibiting tumor growth, in a subject who has become resistant to treatment, by administering to a subject an effective amount of a proteasome inhibitor and an effective amount of a therapeutic agent, e.g., a chemotherapeutic agent. The present invention further relates to methods for purging bone marrow, i.e., removing cancer cells from bone marrow, by exposing the bone marrow cells to a proteasome inhibitor and a therapeutic agent, e.g., a chemotherapeutic agent.

    摘要翻译： 本发明涉及用于治疗癌症或预防受试者中癌细胞生长，例如肿瘤生长的治疗组合物。 本发明还涉及通过向受试者施用有效量的蛋白酶体抑制剂和有效量的治疗剂来治疗已经变得耐受治疗的受试者的癌症的方法，例如抑制肿瘤生长，例如， 化疗剂。 本发明还涉及通过将骨髓细胞暴露于蛋白酶体抑制剂和治疗剂例如化学治疗剂来清除骨髓，即从骨髓中除去癌细胞的方法。

    Methods and compositions for treating cancer using proteasome inhibitors
    2.
    发明授权
    Methods and compositions for treating cancer using proteasome inhibitors 有权
    使用蛋白酶体抑制剂治疗癌症的方法和组合物

    公开(公告)号：US08685954B2

    公开(公告)日：2014-04-01

    申请号：US13242209

    申请日：2011-09-23

    申请人： Kenneth C. Anderson ,  Teru Hideshima ,  Constantine S. Mitsiades ,  Nicholas Mitsiades

    发明人： Kenneth C. Anderson ,  Teru Hideshima ,  Constantine S. Mitsiades ,  Nicholas Mitsiades

    IPC分类号： A61K38/08 ,  A61K38/05 ,  A61K31/04

    CPC分类号： A61K31/69 ,  A61K31/195 ,  A61K31/198 ,  A61K31/573 ,  A61K31/704 ,  A61K38/05 ,  A61K45/06 ,  A61K2300/00

    摘要： The present invention relates to therapeutic compositions for treating cancer or preventing the growth of cancer cells, e.g., tumor growth, in a subject. The present invention also relates to methods for treating cancer, e.g., inhibiting tumor growth, in a subject who has become resistant to treatment, by administering to a subject an effective amount of a proteasome inhibitor and an effective amount of a therapeutic agent, e.g., a chemotherapeutic agent. The present invention further relates to methods for purging bone marrow, i.e., removing cancer cells from bone marrow, by exposing the bone marrow cells to a proteasome inhibitor and a therapeutic agent, e.g., a chemotherapeutic agent.

    摘要翻译： 本发明涉及用于治疗癌症或预防受试者中癌细胞生长，例如肿瘤生长的治疗组合物。 本发明还涉及通过向受试者施用有效量的蛋白酶体抑制剂和有效量的治疗剂来治疗已经变得耐受治疗的受试者的癌症的方法，例如抑制肿瘤生长，例如， 化疗剂。 本发明还涉及通过将骨髓细胞暴露于蛋白酶体抑制剂和治疗剂例如化学治疗剂来清除骨髓，即从骨髓中除去癌细胞的方法。

    Methods and compositions for treating cancer using proteasome inhibitors
    3.
    发明授权
    Methods and compositions for treating cancer using proteasome inhibitors 有权
    使用蛋白酶体抑制剂治疗癌症的方法和组合物

    公开(公告)号：US08026230B2

    公开(公告)日：2011-09-27

    申请号：US11119473

    申请日：2005-04-29

    申请人： Kenneth C. Anderson ,  Teru Hideshima ,  Constantine S. Mitsiades ,  Nicholas Mitsiades

    发明人： Kenneth C. Anderson ,  Teru Hideshima ,  Constantine S. Mitsiades ,  Nicholas Mitsiades

    IPC分类号： A61K38/08 ,  A61K38/05 ,  A61K31/04

    CPC分类号： A61K31/69 ,  A61K31/195 ,  A61K31/198 ,  A61K31/573 ,  A61K31/704 ,  A61K38/05 ,  A61K45/06 ,  A61K2300/00

    摘要： The present invention relates to therapeutic compositions for treating cancer or preventing the growth of cancer cells, e.g., tumor growth, in a subject. The present invention also relates to methods for treating cancer, e.g., inhibiting tumor growth, in a subject who has become resistant to treatment, by administering to a subject an effective amount of a proteasome inhibitor and an effective amount of a therapeutic agent, e.g., a chemotherapeutic agent. The present invention further relates to methods for purging bone marrow, i.e., removing cancer cells from bone marrow, by exposing the bone marrow cells to a proteasome inhibitor and a therapeutic agent, e.g., a chemotherapeutic agent.

    摘要翻译： 本发明涉及用于治疗癌症或预防受试者中癌细胞生长，例如肿瘤生长的治疗组合物。 本发明还涉及通过向受试者施用有效量的蛋白酶体抑制剂和有效量的治疗剂来治疗已经变得耐受治疗的受试者的癌症的方法，例如抑制肿瘤生长，例如， 化疗剂。 本发明还涉及通过将骨髓细胞暴露于蛋白酶体抑制剂和治疗剂例如化学治疗剂来清除骨髓，即从骨髓中除去癌细胞的方法。

    Use of reversine and analogs for treatment of cancer
    4.
    发明授权
    Use of reversine and analogs for treatment of cancer 失效
    使用逆转和类似物治疗癌症

    公开(公告)号：US08466147B2

    公开(公告)日：2013-06-18

    申请号：US12514360

    申请日：2007-11-12

    申请人： Kenneth C. Anderson ,  Nicholas Mitsiades ,  Joseph Negri ,  Douglas W. McMillin ,  Constantine S. Mitsiades

    发明人： Kenneth C. Anderson ,  Nicholas Mitsiades ,  Joseph Negri ,  Douglas W. McMillin ,  Constantine S. Mitsiades

    IPC分类号： A61K31/52

    CPC分类号： A61K31/52 ,  A61K45/06 ,  A61K2300/00

    摘要： Herein is provided methods and compositions for treating cancer. In one embodiment, a method is provided for treating a patient suffering from cancer, the method comprising administering to the patient an effective amount of reversine, reversine analog or reversine containing agent. In another embodiment, compositions comprising reversine are provided. Such compositions may further comprise additional active agents and other additives. The compositions and methods provided herein are useful, for example, in the area of medicine.

    摘要翻译： 本文提供了治疗癌症的方法和组合物。 在一个实施方案中，提供了一种用于治疗患有癌症的患者的方法，所述方法包括向患者施用有效量的逆转，逆转类似物或逆转剂。 在另一个实施方案中，提供了包含逆转的组合物。 这样的组合物还可以包含另外的活性剂和其它添加剂。 本文提供的组合物和方法可用于例如医学领域。

    Methods and compositions for treating cancer using proteasome inhibitors
    8.
    发明申请
    Methods and compositions for treating cancer using proteasome inhibitors 有权
    使用蛋白酶体抑制剂治疗癌症的方法和组合物

    公开(公告)号：US20050267037A1

    公开(公告)日：2005-12-01

    申请号：US11119473

    申请日：2005-04-29

    申请人： Kenneth Anderson ,  Teru Hideshima ,  Constantine Mitsiades ,  Nicholas Mitsiades

    发明人： Kenneth Anderson ,  Teru Hideshima ,  Constantine Mitsiades ,  Nicholas Mitsiades

    IPC分类号： A61K31/00 ,  A61K31/69 ,  A61K31/704 ,  A61K38/05 ,  A61K38/08

    CPC分类号： A61K31/69 ,  A61K31/195 ,  A61K31/198 ,  A61K31/573 ,  A61K31/704 ,  A61K38/05 ,  A61K45/06 ,  A61K2300/00

    摘要： The present invention relates to therapeutic compositions for treating cancer or preventing the growth of cancer cells, e.g., tumor growth, in a subject. The present invention also relates to methods for treating cancer, e.g., inhibiting tumor growth, in a subject who has become resistant to treatment, by administering to a subject an effective amount of a proteasome inhibitor and an effective amount of a therapeutic agent, e.g., a chemotherapeutic agent. The present invention further relates to methods for purging bone marrow, i.e., removing cancer cells from bone marrow, by exposing the bone marrow cells to a proteasome inhibitor and a therapeutic agent, e.g., a chemotherapeutic agent.

    摘要翻译： 本发明涉及用于治疗癌症或预防受试者中癌细胞生长，例如肿瘤生长的治疗组合物。 本发明还涉及通过向受试者施用有效量的蛋白酶体抑制剂和有效量的治疗剂来治疗已经变得耐受治疗的受试者的癌症的方法，例如抑制肿瘤生长，例如， 化疗剂。 本发明还涉及通过将骨髓细胞暴露于蛋白酶体抑制剂和治疗剂例如化学治疗剂来清除骨髓，即从骨髓中除去癌细胞的方法。