发明授权
US08034342B2 Pharmaceutical compositions, kits, and therapeutic uses of antagonist antibodies to IL-17E
有权
IL-17E拮抗剂抗体的药物组合物，试剂盒和治疗用途
- 专利标题： Pharmaceutical compositions, kits, and therapeutic uses of antagonist antibodies to IL-17E
- 专利标题（中）： IL-17E拮抗剂抗体的药物组合物，试剂盒和治疗用途
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申请号： US12549497申请日： 2009-08-28
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公开(公告)号： US08034342B2公开(公告)日： 2011-10-11
- 发明人: Jian Chen , Ellen Filvaroff , Sherman Fong , Dorothy French , Audrey Goddard , Paul J. Godowski , J. Christopher Grimaldi , Austin L. Gurney , Kenneth J. Hillan , Sarah G. Hymowitz , Hanzhong Li , James Pan , Melissa A. Starovasnik , Daniel Tumas , Menno Van Lookeren , Richard Vandlen , Colin K. Watanabe , P. Mickey Williams , William I. Wood , Daniel G. Yansura
- 申请人： Jian Chen , Ellen Filvaroff , Sherman Fong , Dorothy French , Audrey Goddard , Paul J. Godowski , J. Christopher Grimaldi , Austin L. Gurney , Kenneth J. Hillan , Sarah G. Hymowitz , Hanzhong Li , James Pan , Melissa A. Starovasnik , Daniel Tumas , Menno Van Lookeren , Richard Vandlen , Colin K. Watanabe , P. Mickey Williams , William I. Wood , Daniel G. Yansura
- 申请人地址： US CA So. San Francisco
- 专利权人： Genentech, Inc.
- 当前专利权人： Genentech, Inc.
- 当前专利权人地址： US CA So. San Francisco
- 代理机构： Arnold & Porter LLP
- 代理商 Bonny G. Yeung; Ginger R. Dreger
- 主分类号： A61K39/00
- IPC分类号： A61K39/00 ; A61K39/395
摘要：
The present invention is directed to novel polypeptides having sequence identity with IL-17, IL-17 receptors and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.
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