发明授权
- 专利标题： Radioactive mixture and manufacturing method thereof
- 专利标题（中）： 放射性混合物及其制造方法
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申请号： US12354815申请日： 2009-01-16
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公开(公告)号： US08048405B2公开(公告)日： 2011-11-01
- 发明人: Tsai-Yueh Luo , I-Chung Tang , Show-Wen Liu , Yu-Lung Wu , Cheng-Hsien Lin , Cheng-Fang Hsu , Kwei-Luen Hsu , Chang-Mau Sheng , Ching-Jun Liou , Te-Sheng Liang
- 申请人： Tsai-Yueh Luo , I-Chung Tang , Show-Wen Liu , Yu-Lung Wu , Cheng-Hsien Lin , Cheng-Fang Hsu , Kwei-Luen Hsu , Chang-Mau Sheng , Ching-Jun Liou , Te-Sheng Liang
- 申请人地址： TW Taoyuan County
- 专利权人： Atomic Energy Council-Institute of Nuclear Energy Research
- 当前专利权人： Atomic Energy Council-Institute of Nuclear Energy Research
- 当前专利权人地址： TW Taoyuan County
- 代理机构： Sinorica, LLC
- 代理商 Ming Chow
- 主分类号： A61K49/00
- IPC分类号： A61K49/00
摘要：
A radioactive mixture and a manufacturing method thereof are disclosed. The radioactive mixture (188Re-MN/Lipiodol mixture) is formed by chelating reaction of MN series compounds that are amine-amide-disulfide amine quadric-dentate chelate ligands with TcO4−/or ReO4−, and then dissolved in Lipiodol. Moreover, the 99mTc/or 188Re of the TcO4−/or ReO4− avoids bone marrow injuries caused by free 90Y. By the feature of the Lipiodol that stays in liver tumors for a long period, the radioactive mixture is applied to treat liver cancers by injection so that injuries caused by surgical operations can be prevented. 188Re-MN/Lipiodol is used for liver cancer, breast cancer or other solid tumors treatment. Re-188 MN or Re-188 MN/Lipiodol can be mixed with anticancer drugs, hydrogel, liposome, micelle or other nano-particles to form the multifunctional therapeutic modality.
公开/授权文献
- US20100183508A1 RADIOACTIVE MIXTURE AND MANUFACTURING METHOD THEREOF 公开/授权日：2010-07-22