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    RADIOACTIVE MIXTURE AND MANUFACTURING METHOD THEREOF
    1.
    发明申请
    RADIOACTIVE MIXTURE AND MANUFACTURING METHOD THEREOF 有权
    放射性混合物及其制造方法

    公开(公告)号：US20100183508A1

    公开(公告)日：2010-07-22

    申请号：US12354815

    申请日：2009-01-16

    申请人： Tsai-Yueh LUO ,  I-Chung Tang ,  Show-Wen Liu ,  Yu-Lung Wu ,  Cheng-Hsien Lin ,  Cheng-Fang Hsu ,  Kwei-Luen Hsu ,  Chang-Mau Sheng ,  Ching-Jun Liou ,  Te-Sheng Liang

    发明人： Tsai-Yueh LUO ,  I-Chung Tang ,  Show-Wen Liu ,  Yu-Lung Wu ,  Cheng-Hsien Lin ,  Cheng-Fang Hsu ,  Kwei-Luen Hsu ,  Chang-Mau Sheng ,  Ching-Jun Liou ,  Te-Sheng Liang

    IPC分类号： A61K51/04 ,  A61P35/00

    CPC分类号： A61K51/0478 ,  A61K49/0438

    摘要： A radioactive mixture and a manufacturing method thereof are disclosed. The radioactive mixture (188Re-MN/Lipiodol mixture) is formed by chelating reaction of MN series compounds that are amine-amide-disulfide amine quadric-dentate chelate ligands with TcO4−/or ReO4−, and then dissolved in Lipiodol. Moreover, the 99mTc/or 188Re of the TcO4−/or ReO4− avoids bone marrow injuries caused by free 90Y. By the feature of the Lipiodol that stays in liver tumors for a long period, the radioactive mixture is applied to treat liver cancers by injection so that injuries caused by surgical operations can be prevented. 188Re-MN/Lipiodol is used for liver cancer, breast cancer or other solid tumors treatment. Re-188 MN or Re-188 MN/Lipiodol can be mixed with anticancer drugs, hydrogel, liposome, micelle or other nano-particles to form the multifunctional therapeutic modality.

    摘要翻译： 公开了放射性混合物及其制造方法。 通过胺胺 - 二硫化胺胺二齿螯合配体的MN系列化合物与TcO4-或ReO4-螯合反应形成放射性混合物（188Re-MN / Lipiodol混合物），然后溶解于Lipiodol中。 此外，TcO4- /或ReO4的99mTc /或188Re避免了由自由90Y引起的骨髓损伤。 通过长时间停留在肝肿瘤中的碘碘醇的特征，通过注射施用放射性混合物来治疗肝癌，从而可以预防外科手术引起的损伤。 188Re-MN / Lipiodol用于肝癌，乳腺癌或其他实体瘤治疗。 Re-188 MN或Re-188 MN / Lipiodol可与抗癌药物，水凝胶，脂质体，胶束或其他纳米颗粒混合，形成多功能治疗方式。

    Radioactive mixture and manufacturing method thereof
    3.
    发明授权
    Radioactive mixture and manufacturing method thereof 有权
    放射性混合物及其制造方法

    公开(公告)号：US08048405B2

    公开(公告)日：2011-11-01

    申请号：US12354815

    申请日：2009-01-16

    申请人： Tsai-Yueh Luo ,  I-Chung Tang ,  Show-Wen Liu ,  Yu-Lung Wu ,  Cheng-Hsien Lin ,  Cheng-Fang Hsu ,  Kwei-Luen Hsu ,  Chang-Mau Sheng ,  Ching-Jun Liou ,  Te-Sheng Liang

    发明人： Tsai-Yueh Luo ,  I-Chung Tang ,  Show-Wen Liu ,  Yu-Lung Wu ,  Cheng-Hsien Lin ,  Cheng-Fang Hsu ,  Kwei-Luen Hsu ,  Chang-Mau Sheng ,  Ching-Jun Liou ,  Te-Sheng Liang

    IPC分类号： A61K49/00

    CPC分类号： A61K51/0478 ,  A61K49/0438

    摘要： A radioactive mixture and a manufacturing method thereof are disclosed. The radioactive mixture (188Re-MN/Lipiodol mixture) is formed by chelating reaction of MN series compounds that are amine-amide-disulfide amine quadric-dentate chelate ligands with TcO4−/or ReO4−, and then dissolved in Lipiodol. Moreover, the 99mTc/or 188Re of the TcO4−/or ReO4− avoids bone marrow injuries caused by free 90Y. By the feature of the Lipiodol that stays in liver tumors for a long period, the radioactive mixture is applied to treat liver cancers by injection so that injuries caused by surgical operations can be prevented. 188Re-MN/Lipiodol is used for liver cancer, breast cancer or other solid tumors treatment. Re-188 MN or Re-188 MN/Lipiodol can be mixed with anticancer drugs, hydrogel, liposome, micelle or other nano-particles to form the multifunctional therapeutic modality.

    摘要翻译： 公开了放射性混合物及其制造方法。 通过胺胺 - 二硫化胺胺二齿螯合配体的MN系列化合物与TcO4-或ReO4-螯合反应形成放射性混合物（188Re-MN / Lipiodol混合物），然后溶于Lipiodol中。 此外，TcO4- /或ReO4的99mTc /或188Re避免了由自由90Y引起的骨髓损伤。 通过长时间停留在肝肿瘤中的碘碘醇的特征，通过注射施用放射性混合物来治疗肝癌，从而可以预防外科手术引起的损伤。 188Re-MN / Lipiodol用于肝癌，乳腺癌或其他实体瘤治疗。 Re-188 MN或Re-188 MN / Lipiodol可与抗癌药物，水凝胶，脂质体，胶束或其他纳米颗粒混合，形成多功能治疗方式。

    Combination set of Meta-Iodobenzyl guanidine freezing crystal and making method thereof and method for making a radioactive iodine marker
    4.
    发明申请
    Combination set of Meta-Iodobenzyl guanidine freezing crystal and making method thereof and method for making a radioactive iodine marker 审中-公开
    组合甲基碘苄胍冷冻结晶及其制备方法和制备放射性碘标记物的方法

    公开(公告)号：US20080241063A1

    公开(公告)日：2008-10-02

    申请号：US11727996

    申请日：2007-03-29

    申请人： Tsai-Yueh Luo ,  Te-Sheng Liang ,  Chang-Mau Shing ,  Shiou-Shiow Farn ,  Wuu-Jyh Lin ,  Haw-Jan Chen

    发明人： Tsai-Yueh Luo ,  Te-Sheng Liang ,  Chang-Mau Shing ,  Shiou-Shiow Farn ,  Wuu-Jyh Lin ,  Haw-Jan Chen

    IPC分类号： A61K51/00 ,  C07C279/02

    CPC分类号： A61K51/0406 ,  A61K51/1282 ,  C07C279/06

    摘要： The present invention relates to a combination set of meta-iodobenzyl guanidine (MIBG) freezing crystal and making method thereof and method of radioactive marker for making. The combination set of freezing crystal includes a first container having freezing crystal and a second container having sodium acetate buffer solution. The method for making a combination set of freezing crystal includes the steps of mixing (meta-iodobenzyl guanidine)2·sulfuric acid and ammonium sulfate into first non-pyrogenic injection water; getting a first container having freezing crystal after freezing and drying; and getting a second container having the sodium acetate buffer solution after sterilizing. The method of radioactive marker for making includes the steps of adding radioactive iodine ion into freezing crystal to react and adding sodium acetate buffer solution to get radioactive MIBG solution. The present invention adjusts agent easily and is instant to use so the radioactive iodine marker don't lose activity easily before using it.

    摘要翻译： 本发明涉及一种间碘碘苄基胍（MIBG）冷冻结晶的组合及其制备方法和放射性标记物的制备方法。 冷冻结晶组合包括具有冷冻晶体的第一容器和具有乙酸钠缓冲溶液的第二容器。 制备冷冻结晶组合的方法包括将（间碘碘苄基胍）亚磺酸和硫酸铵混合到第一非致热性注射水中的步骤; 在冷冻和干燥后得到具有冷冻晶体的第一容器; 并在灭菌后得到具有乙酸钠缓冲溶液的第二容器。 放射性标记物的制备方法包括将放射性碘离子加入冷冻结晶反应并加入乙酸钠缓冲溶液，得到放射性MIBG溶液的步骤。 本发明容易调节剂并且即时使用，所以放射性碘标记物在使用前不容易失去活性。