公开(公告)号：US20100111860A1

公开(公告)日：2010-05-06

申请号：US12263573

申请日：2008-11-03

Applicant: Tsai-Yueh LUO ,  I-Chung Tang ,  Jian-Wen Chen ,  Kwei-Luen Hsu ,  Yu-Lung Wu ,  Te-Sheng Liang ,  Chang-Mau Sheng ,  Jin-Jenn Lin ,  Ching-Jun Liou ,  Jyh-Daw Sheu

Inventor： Tsai-Yueh LUO ,  I-Chung Tang ,  Jian-Wen Chen ,  Kwei-Luen Hsu ,  Yu-Lung Wu ,  Te-Sheng Liang ,  Chang-Mau Sheng ,  Jin-Jenn Lin ,  Ching-Jun Liou ,  Jyh-Daw Sheu

IPC: A61K51/06 ,  C08B37/08 ,  A61P35/00

CPC classification number: A61K51/065 ,  C08B37/003 ,  C08L5/08

Abstract: A radioactive material containing chitosan for inhibiting cancer and a preparation method thereof are revealed. The adioactive material containing chitosan is formed by using SOCTA chelating agent to connect chitosan and radionuclides such as 188Re, and Tc-99m etc. The preparation method of the radioactive material containing chitosan includes the steps of: prepare SOCTA-Chitosan compound; and prepare M(radionuclide)-SOCTA-Chitosan compound. By biocompatibility and clotting in alkaline environment of human blood of chitosan, the radioactive material containing chitosan is injected into cancer and staying there for a long time so as to achieve effectively treatment.

Abstract translation: 揭示含有用于抑制癌症的壳聚糖的放射性物质及其制备方法。 通过使用SOCTA螯合剂将壳聚糖与188Re，Tc-99m等放射性核素连接起来形成含有壳聚糖的活性物质。含有脱乙酰壳多糖的放射性物质的制备方法包括以下步骤：制备SOCTA-壳聚糖化合物; 并制备M（放射性核素）-SOCTA-壳聚糖化合物。 通过壳聚糖人血液碱性环境的生物相容性和凝血作用，将含有脱乙酰壳多糖的放射性物质注入癌症并长时间停留，以有效治疗。

公开(公告)号：US08367811B2

公开(公告)日：2013-02-05

申请号：US12263573

申请日：2008-11-03

Applicant: Tsai-Yueh Luo ,  I-Chung Tang ,  Jian-Wen Chen ,  Kwei-Luen Hsu ,  Yu-Lung Wu ,  Te-Sheng Liang ,  Chang-Mau Sheng ,  Jin-Jenn Lin ,  Ching-Jun Liou ,  Jyh-Daw Sheu

Inventor： Tsai-Yueh Luo ,  I-Chung Tang ,  Jian-Wen Chen ,  Kwei-Luen Hsu ,  Yu-Lung Wu ,  Te-Sheng Liang ,  Chang-Mau Sheng ,  Jin-Jenn Lin ,  Ching-Jun Liou ,  Jyh-Daw Sheu

IPC: C07F13/00

CPC classification number: A61K51/065 ,  C08B37/003 ,  C08L5/08

Abstract: A radioactive material containing chitosan for inhibiting cancer and a preparation method thereof are revealed. The adioactive material containing chitosan is formed by using SOCTA chelating agent to connect chitosan and radionuclides such as 188Re, and Tc-99m etc. The preparation method of the radioactive material containing chitosan includes the steps of: prepare SOCTA-Chitosan compound; and prepare M(radionuclide)-SOCTA-Chitosan compound. By biocompatibility and clotting in alkaline environment of human blood of chitosan, the radioactive material containing chitosan is injected into cancer and staying there for a long time so as to achieve effectively treatment.

Abstract translation: 揭示含有用于抑制癌症的壳聚糖的放射性物质及其制备方法。 通过使用SOCTA螯合剂将壳聚糖与188Re，Tc-99m等放射性核素连接起来形成含有壳聚糖的活性物质。含有脱乙酰壳多糖的放射性物质的制备方法包括以下步骤：制备SOCTA-壳聚糖化合物; 并制备M（放射性核素）-SOCTA-壳聚糖化合物。 通过壳聚糖人血液碱性环境的生物相容性和凝血作用，将含有脱乙酰壳多糖的放射性物质注入癌症并长时间停留，以有效治疗。

公开(公告)号：US20100183508A1

公开(公告)日：2010-07-22

申请号：US12354815

申请日：2009-01-16

Applicant: Tsai-Yueh LUO ,  I-Chung Tang ,  Show-Wen Liu ,  Yu-Lung Wu ,  Cheng-Hsien Lin ,  Cheng-Fang Hsu ,  Kwei-Luen Hsu ,  Chang-Mau Sheng ,  Ching-Jun Liou ,  Te-Sheng Liang

Inventor： Tsai-Yueh LUO ,  I-Chung Tang ,  Show-Wen Liu ,  Yu-Lung Wu ,  Cheng-Hsien Lin ,  Cheng-Fang Hsu ,  Kwei-Luen Hsu ,  Chang-Mau Sheng ,  Ching-Jun Liou ,  Te-Sheng Liang

IPC: A61K51/04 ,  A61P35/00

CPC classification number: A61K51/0478 ,  A61K49/0438

Abstract: A radioactive mixture and a manufacturing method thereof are disclosed. The radioactive mixture (188Re-MN/Lipiodol mixture) is formed by chelating reaction of MN series compounds that are amine-amide-disulfide amine quadric-dentate chelate ligands with TcO4−/or ReO4−, and then dissolved in Lipiodol. Moreover, the 99mTc/or 188Re of the TcO4−/or ReO4− avoids bone marrow injuries caused by free 90Y. By the feature of the Lipiodol that stays in liver tumors for a long period, the radioactive mixture is applied to treat liver cancers by injection so that injuries caused by surgical operations can be prevented. 188Re-MN/Lipiodol is used for liver cancer, breast cancer or other solid tumors treatment. Re-188 MN or Re-188 MN/Lipiodol can be mixed with anticancer drugs, hydrogel, liposome, micelle or other nano-particles to form the multifunctional therapeutic modality.

Abstract translation: 公开了放射性混合物及其制造方法。 通过胺胺 - 二硫化胺胺二齿螯合配体的MN系列化合物与TcO4-或ReO4-螯合反应形成放射性混合物（188Re-MN / Lipiodol混合物），然后溶解于Lipiodol中。 此外，TcO4- /或ReO4的99mTc /或188Re避免了由自由90Y引起的骨髓损伤。 通过长时间停留在肝肿瘤中的碘碘醇的特征，通过注射施用放射性混合物来治疗肝癌，从而可以预防外科手术引起的损伤。 188Re-MN / Lipiodol用于肝癌，乳腺癌或其他实体瘤治疗。 Re-188 MN或Re-188 MN / Lipiodol可与抗癌药物，水凝胶，脂质体，胶束或其他纳米颗粒混合，形成多功能治疗方式。

公开(公告)号：US08048405B2

公开(公告)日：2011-11-01

申请号：US12354815

申请日：2009-01-16

Applicant: Tsai-Yueh Luo ,  I-Chung Tang ,  Show-Wen Liu ,  Yu-Lung Wu ,  Cheng-Hsien Lin ,  Cheng-Fang Hsu ,  Kwei-Luen Hsu ,  Chang-Mau Sheng ,  Ching-Jun Liou ,  Te-Sheng Liang

Inventor： Tsai-Yueh Luo ,  I-Chung Tang ,  Show-Wen Liu ,  Yu-Lung Wu ,  Cheng-Hsien Lin ,  Cheng-Fang Hsu ,  Kwei-Luen Hsu ,  Chang-Mau Sheng ,  Ching-Jun Liou ,  Te-Sheng Liang

IPC: A61K49/00

CPC classification number: A61K51/0478 ,  A61K49/0438

Abstract: A radioactive mixture and a manufacturing method thereof are disclosed. The radioactive mixture (188Re-MN/Lipiodol mixture) is formed by chelating reaction of MN series compounds that are amine-amide-disulfide amine quadric-dentate chelate ligands with TcO4−/or ReO4−, and then dissolved in Lipiodol. Moreover, the 99mTc/or 188Re of the TcO4−/or ReO4− avoids bone marrow injuries caused by free 90Y. By the feature of the Lipiodol that stays in liver tumors for a long period, the radioactive mixture is applied to treat liver cancers by injection so that injuries caused by surgical operations can be prevented. 188Re-MN/Lipiodol is used for liver cancer, breast cancer or other solid tumors treatment. Re-188 MN or Re-188 MN/Lipiodol can be mixed with anticancer drugs, hydrogel, liposome, micelle or other nano-particles to form the multifunctional therapeutic modality.

Abstract translation: 公开了放射性混合物及其制造方法。 通过胺胺 - 二硫化胺胺二齿螯合配体的MN系列化合物与TcO4-或ReO4-螯合反应形成放射性混合物（188Re-MN / Lipiodol混合物），然后溶于Lipiodol中。 此外，TcO4- /或ReO4的99mTc /或188Re避免了由自由90Y引起的骨髓损伤。 通过长时间停留在肝肿瘤中的碘碘醇的特征，通过注射施用放射性混合物来治疗肝癌，从而可以预防外科手术引起的损伤。 188Re-MN / Lipiodol用于肝癌，乳腺癌或其他实体瘤治疗。 Re-188 MN或Re-188 MN / Lipiodol可与抗癌药物，水凝胶，脂质体，胶束或其他纳米颗粒混合，形成多功能治疗方式。

公开(公告)号：US20070258885A1

公开(公告)日：2007-11-08

申请号：US11429194

申请日：2006-05-08

Applicant: Tsai-Yueh Luo ,  Ai-Ren Lo ,  Wuu-Jyh Lin ,  Tseng-Chung Huang ,  Bor-Tsung Hsieh ,  Ching-Jun Liou

Inventor： Tsai-Yueh Luo ,  Ai-Ren Lo ,  Wuu-Jyh Lin ,  Tseng-Chung Huang ,  Bor-Tsung Hsieh ,  Ching-Jun Liou

IPC: A61N5/00 ,  A61K51/00

CPC classification number: G21G4/08 ,  A61K51/1282 ,  G21H5/02

Abstract: A device for concentrating 99mTc pertechnetate and a method thereof are disclosed. The device includes a concentration device, a control device and a central processing unit. The concentration device is for concentrating 99mTc pertechnetate, the control device connects with each members of the concentration device, and the central processing unit is used for saving an automatic control program. The automatic control program is run by the central processing unit so as to detect and monitor weight as well as activity of the concentrated 99mTc pertechnetate. Due to the automatical control, the concentration quality and production efficiency of the 99mTc pertechnetate are improved. Moreover, the radiation dose received by users is reduced.

Abstract translation: 公开了一种用于浓缩超高锝酸盐99m Tc的装置及其方法。 该装置包括集中装置，控制装置和中央处理装置。 浓缩装置用于浓缩高碘酸钠99m Tc，控制装置与浓缩装置的每个构件连接，中央处理单元用于保存自动控制程序。 自动控制程序由中央处理单元运行，以便检测和监测浓缩的99m Tc高温酸盐的重量以及活性。 由于自动控制，提高了99m Tc高锝酸盐的浓度质量和生产效率。 此外，用户接收的辐射剂量减少。