发明授权
US08053477B2 Inhibitors of the S100-p53 protein-protein interaction and method of inhibiting cancer employing the same
有权
S100-p53蛋白相互作用的抑制剂和抑制癌症的方法相同
- 专利标题： Inhibitors of the S100-p53 protein-protein interaction and method of inhibiting cancer employing the same
- 专利标题（中）： S100-p53蛋白相互作用的抑制剂和抑制癌症的方法相同
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申请号： US10397239申请日： 2003-03-27
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公开(公告)号： US08053477B2公开(公告)日： 2011-11-08
- 发明人: David J. Weber , Joseph Markowitz , France Carrier , Alexander D. MacKerell
- 申请人： David J. Weber , Joseph Markowitz , France Carrier , Alexander D. MacKerell
- 申请人地址： US MD Baltimore
- 专利权人： University of Maryland, Baltimore
- 当前专利权人： University of Maryland, Baltimore
- 当前专利权人地址： US MD Baltimore
- 代理机构： Morgan, Lewis & Bockius, LLP
- 主分类号： A01N37/52
- IPC分类号： A01N37/52 ; A01N31/14 ; A61K31/155 ; A61K31/075 ; G01N33/53
摘要：
Compounds that bind S100 and inhibit the S100-p53 protein-protein interaction and activate the tumor suppressor activity of p53, and thus which have an antineoplastic effect are disclosed, as well as methods for identifying these compounds, compositions comprising the same, and methods of using the same to treat cancer.
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