A clip applier includes a body 21, an insertion tube 22 extending from the body 21 and inserted in a channel of an endoscope and a clamp mechanism 24 disposed at a distal end of the insertion tube 22. The clamp mechanism 24 has a support member 28 fixed at the distal end of the insertion tube 22 and a pair of clamp members 30 rotatably supported by the support member 28. The clamp members 30 are connected to a distal end of a wire 25 via a pair of links 35. The clamp members 30 respectively include gripping portions 32 protruding form the support member 28. A clip 50 is received in receiving grooves 32a of the gripping portions 32. When the wire 25 is pulled by operating an operation member disposed on the body 21, the clamp members 30 are rotated against an elastic force of a hinge portion 51 of the clip 50, thereby causing a pair of clip portions 53 of the clip 50 to be opened.