发明授权
US08067614B2 N-substituted (benzoimidazol-2-yl)phenylamines, processes for their preparation, their use as a medicament or diagnostic aid, and a medicament comprising them
失效
N-取代的（苯并咪唑-2-基）苯胺，其制备方法，它们作为药物或诊断助剂的用途，以及包含它们的药物
- 专利标题： N-substituted (benzoimidazol-2-yl)phenylamines, processes for their preparation, their use as a medicament or diagnostic aid, and a medicament comprising them
- 专利标题（中）： N-取代的（苯并咪唑-2-基）苯胺，其制备方法，它们作为药物或诊断助剂的用途，以及包含它们的药物
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申请号： US12722634申请日： 2010-03-12
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公开(公告)号： US08067614B2公开(公告)日： 2011-11-29
- 发明人: Uwe Heinelt , Hans-Jochen Lang , Armin Hofmeister , Klaus Wirth , Martin Hug
- 申请人： Uwe Heinelt , Hans-Jochen Lang , Armin Hofmeister , Klaus Wirth , Martin Hug
- 申请人地址： DE Frankfurt am Main
- 专利权人： Sanofi-Aventis Deutschland GmbH
- 当前专利权人： Sanofi-Aventis Deutschland GmbH
- 当前专利权人地址： DE Frankfurt am Main
- 代理机构： Scully, Scott, Murphy & Presser, P.C.
- 代理商 Jiang Lin
- 优先权： DE10304294 20030204
- 主分类号： A61K31/4184
- IPC分类号： A61K31/4184 ; C07D235/30
摘要：
This invention is directed to the compound of formula (I), compositions containing said compounds to inhibit the sodium-proton exchanger of subtype 3 (NHE3) which are useful in the prevention or treatment of various disorders in a patient suffering from a disease state, such as, renal disorders including acute or chronic renal failure, disorders of biliary function and for respiratory disorders such as snoring or sleep apnea or for stroke.