Invention Grant
US08076372B2 Acythiols and component thiol compositions as anti-HIV and anti-retroviral agents
有权
亚硫醇和组分硫醇组合物作为抗HIV和抗逆转录病毒剂
- Patent Title: Acythiols and component thiol compositions as anti-HIV and anti-retroviral agents
- Patent Title (中): 亚硫醇和组分硫醇组合物作为抗HIV和抗逆转录病毒剂
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Application No.: US12414321Application Date: 2009-03-30
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Publication No.: US08076372B2Publication Date: 2011-12-13
- Inventor: John K. Inman , Atul Goel , Ettore Appella , Jim A. Turpin , Marco Schito
- Applicant: John K. Inman , Atul Goel , Ettore Appella , Jim A. Turpin , Marco Schito
- Applicant Address: US MD Rockville
- Assignee: Government of the United States
- Current Assignee: Government of the United States
- Current Assignee Address: US MD Rockville
- Agency: Cantor Colburn LLP
- Main IPC: A61K31/21
- IPC: A61K31/21
Abstract:
Certain thiol and acylthiol compounds inhibit retrovirus growth by attacking the highly conserved zinc finger regions of essential viral proteins. These compounds, compositions containing them, and methods of using them to treat retroviral infections such as HIV are described. These compounds are also useful for preparation of vaccines comprised of inactivated retroviruses such as HIV, prevention of the transmission of such retroviruses, and detection of retroviral proteins.
Public/Granted literature
- US20090247473A1 ACYTHIOLS AND COMPONENT THIOL COMPOSITIONS AS ANTI-HIV AND ANTI-RETROVIRAL AGENTS Public/Granted day:2009-10-01
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