公开(公告)号：US11504673B2

公开(公告)日：2022-11-22

申请号：US16638817

申请日：2018-08-15

申请人： University of Delaware ,  Government of the United States, as Represented by the Defense Threat Reduction Agency ,  Government of the United States, as Represented by the Secretary of the Army

发明人： Gregory W. Peterson ,  Annie Lu ,  Thomas H. Epps, III ,  Jean S. Epps

IPC分类号： B01D69/12 ,  B01D53/22 ,  B01D67/00 ,  B01D69/14 ,  B01D71/02 ,  B01D71/80 ,  B32B7/12 ,  B32B27/08 ,  B32B27/18 ,  B32B27/30

摘要： Disclosed herein are multi-layer structures comprising a first composite layer disposed over a second composite layer, wherein the first composite layer contains a first active material dispersed in a first polymer containing an elastomeric polymer and the second composite layer contains a second polymer which may have a second active material dispersed therein, wherein the first active material chemically or physically interacts with at least one toxic chemical and is selected from the group consisting of metal-organic frameworks (MOFs), metal oxides, metal hydroxides, zeolites, and combinations thereof, and wherein the active material and the second active material (if present) are the same as or different from each other, and the first polymer and second polymer are the same as or different from each other, subject to the proviso that the first composite layer and the second composite layer compositionally differ from each other in at least one respect.

公开(公告)号：US20200024289A1

公开(公告)日：2020-01-23

申请号：US16489824

申请日：2018-03-01

申请人： Anacor Pharmaceuticals, Inc. ,  The Government of the United States, as represented by the Secretary of the Army

发明人： Robert Toms Jacobs ,  Yang Liu ,  Richard J. Sciotti ,  Jason D. Speake ,  Gavin Alistair Whitlock ,  Paul Alan Glossop ,  Charles Eric Mowbray ,  Delphine Françoise Monique Launay ,  Stephen John Robinson

IPC分类号： C07F5/02 ,  A61P33/02

摘要： This application describes compounds, compositions, and methods which are useful in treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of a disease caused by a parasite.

公开(公告)号：US20110183856A1

公开(公告)日：2011-07-28

申请号：US12713554

申请日：2010-02-26

申请人： Brian K. Agan ,  Eric H. Hanson ,  Michael J. Jenkins ,  Baochuan Lin ,  Chris C. Olsen ,  Robb K. Rowley ,  David A. Stenger ,  Dzung C. Thach ,  Clark J. Tibbetts ,  Elizabeth A. Walter ,  Jinny Lin Liu

发明人： Brian K. Agan ,  Eric H. Hanson ,  Michael J. Jenkins ,  Baochuan Lin ,  Chris C. Olsen ,  Robb K. Rowley ,  David A. Stenger ,  Dzung C. Thach ,  Clark J. Tibbetts ,  Elizabeth A. Walter ,  Jinny Lin Liu

IPC分类号： C40B30/00

CPC分类号： C12Q1/6883 ,  C12Q1/6806 ,  C12Q2600/158

摘要： The present invention provides a specific set of gene expression markers from peripheral blood leukocytes that are indicative of a host response to exposure, response, and recovery infectious pathogen infections. The present invention further provides methods for identifying the specific set of gene expression markers, methods of monitoring disease progression and treatment of infectious pathogen infections, methods of prognosing the onset of an infectious pathogen infection, and methods of diagnosing an infectious pathogen infection and identifying the pathogen involved.

摘要翻译： 本发明提供来自外周血白细胞的特异性基因表达标志物，其指示宿主对暴露，应答和恢复感染性病原体感染的反应。 本发明还提供了用于鉴定特定基因表达标志物组的方法，监测疾病进展和感染性病原体感染治疗的方法，预测感染性病原体感染发病的方法，诊断感染性病原体感染的方法以及鉴定 涉及病原体。

公开(公告)号：US11253347B2

公开(公告)日：2022-02-22

申请号：US16076040

申请日：2017-02-07

申请人： The Government of the United States, as Represented by the Secretary of the Army ,  Government of the United States of America, as represented by the Secretary of the Commerce

发明人： Brett R. Haupt ,  Matthew E. Staymates ,  Larry E. Bowen ,  Mark M. Bailey ,  Jaime B. Anderson

IPC分类号： A61D7/04 ,  A61M15/00

摘要： A system for conducting inhalation studies includes an inhalation exposure chamber and an aerosol delivery line connected to the inhalation exposure chamber. The aerosol delivery line is configured to produce a bi-directional and symmetrical presentation of aerosol to the inhalation exposure chamber. A laminar flow element is configured to create an ante-chamber where complete and turbulent mixing of the aerosol occurs. A radial exhaust and the laminar flow element enable laminar flow of the aerosol through the inhalation exposure chamber.

公开(公告)号：US20210129086A1

公开(公告)日：2021-05-06

申请号：US16638817

申请日：2018-08-15

申请人： University of Delaware ,  Government of the United States, as Represented by the Defense Threat Reduction Agency ,  Government of the United States, as Represented by the Secrectary of the Army

发明人： Gregory W. Peterson ,  Annie Lu ,  Thomas H. Epps, III ,  Jean S. Epps

IPC分类号： B01D69/12 ,  B01D71/80 ,  B01D69/14 ,  B01D71/02 ,  B32B7/12 ,  B32B27/08 ,  B32B27/30 ,  B32B27/18 ,  B01D67/00 ,  B01D53/22

摘要： Disclosed herein are multi-layer structures comprising a first composite layer disposed over a second composite layer, wherein the first composite layer contains a first active material dispersed in a first polymer containing an elastomeric polymer and the second composite layer contains a second polymer which may have a second active material dispersed therein, wherein the first active material chemically or physically interacts with at least one toxic chemical and is selected from the group consisting of metal-organic frameworks (MOFs), metal oxides, metal hydroxides, zeolites, and combinations thereof, and wherein the active material and the second active material (if present) are the same as or different from each other, and the first polymer and second polymer are the same as or different from each other, subject to the proviso that the first composite layer and the second composite layer compositionally differ from each other in at least one respect.

公开(公告)号：US20100136613A1

公开(公告)日：2010-06-03

申请号：US12630746

申请日：2009-12-03

申请人： Timothy J. O'Leary ,  Jeffrey T. Mason ,  Carol B. Fowler ,  Robert E. Cunningham

发明人： Timothy J. O'Leary ,  Jeffrey T. Mason ,  Carol B. Fowler ,  Robert E. Cunningham

IPC分类号： G01N1/28

CPC分类号： A01N1/0231 ,  G01N1/30

摘要： A method is disclosed for reversing fixation-induced cross-linking in tissue specimens that have been preserved for histological examination. The method involves placing the fixed tissue in a liquid under elevated temperature and pressure conditions that are sufficient to reverse the fixation-induced cross-linking, restore antigenicity to proteins, and permit improved molecular and proteomic analysis of the preserved tissue specimen. Methods are also disclosed for processing tissues for histological examination under elevated pressure conditions that enhance the perfusion of liquid reagents into the tissue and reduce overall processing times.

摘要翻译： 公开了一种用于逆转已经保留用于组织学检查的组织标本中固定诱导交联的方法。 该方法包括将固定组织置于液体中，该温度和压力条件足以逆转固定诱导的交联，恢复对蛋白质的抗原性，并允许改进保藏组织标本的分子和蛋白质组学分析。 还公开了用于处理在升高的压力条件下进行组织学检查的组织的方法，其增强液体试剂灌注到组织中并减少总体加工时间。

公开(公告)号：US20200179506A1

公开(公告)日：2020-06-11

申请号：US16304793

申请日：2017-05-30

申请人： Stephen J. THOMAS ,  Timothy ENDY ,  Kenneth H. ECKELS ,  J. Robert PUTNAK ,  Richard JARMAN ,  Rafael DE LA BARRERA

发明人： Stephen J. THOMAS ,  Timothy ENDY ,  Kenneth H. ECKELS ,  J. Robert PUTNAK ,  Richard JARMAN ,  Rafael DE LA BARRERA

IPC分类号： A61K39/12 ,  C12N7/00

摘要： The invention generally relates to a purified inactivated Zika virus (ZIKV), methods for producing the purified inactivated ZIKV, immunogenic compositions and vaccines comprising the purified inactivated ZIKV and methods for the prevention and/or treatment of infection by ZIKV.

公开(公告)号：US20220034884A1

公开(公告)日：2022-02-03

申请号：US17389645

申请日：2021-07-30

申请人： The Government of the United States of America, as represented by the Secretary of the Navy ,  The Government of the United States of America, as represented by the Secretary, Department of Healt

发明人： Eunkeu Oh ,  Kimihiro Susumu ,  Mason A. Wolak ,  Kirill Gorshkov

IPC分类号： G01N33/569 ,  G01N33/58

摘要： Quantum dots conjugated to SARS-CoV-2 Spike protein receptor binding domain (RBD) interact with gold nanoparticles bound to angiotensin converting enzyme 2 (ACE2) and thus undergo energy transfer. This energy transfer indicates RBD/ACE binding and can be used to assay for inhibitors thereof. Moreover, these labeled quantum dots were found to undergo endocytosis in cells expressing ACE2.

公开(公告)号：US20090170717A1

公开(公告)日：2009-07-02

申请号：US12100519

申请日：2008-04-10

申请人： Brian K. Agan ,  Eric H. Hanson ,  Russell P. Kruzelock ,  Baochuan Lin ,  Robb K. Rowley ,  Donald Seto ,  David A. Stenger ,  Jennifer Johnson ,  Clark J. Tibbetts ,  Dzung C. Thach ,  Gary J. Vora ,  Elizabeth A Walter ,  Zheng Wang

发明人： Brian K. Agan ,  Eric H. Hanson ,  Russell P. Kruzelock ,  Baochuan Lin ,  Robb K. Rowley ,  Donald Seto ,  David A. Stenger ,  Jennifer Johnson ,  Clark J. Tibbetts ,  Dzung C. Thach ,  Gary J. Vora ,  Elizabeth A Walter ,  Zheng Wang

IPC分类号： C40B30/04

CPC分类号： G06F19/22 ,  C12Q1/6874 ,  C12Q1/6888 ,  C12Q1/689 ,  C12Q1/6893 ,  C12Q1/701

摘要： The present invention relates to pathogen detection and identification by use of DNA resequencing microarrays. The present invention also provides resequencing microarray chips for differential diagnosis and serotyping of pathogens present in a biological sample. The present invention further provides methods of detecting the presence and identity of pathogens present in a biological sample.

摘要翻译： 本发明涉及使用DNA重排序微阵列进行病原体检测和鉴定。 本发明还提供用于鉴别诊断和生物样品中存在的病原体血清分型的重新测序微阵列芯片。 本发明还提供了检测存在于生物样品中的病原体的存在和身份的方法。

公开(公告)号：US20240364419A1

公开(公告)日：2024-10-31

申请号：US18403674

申请日：2024-01-03

申请人： The Government of the United States of America, as represented by the Secretary of the Navy

发明人： Tao Wei ,  Thomas Mauldin ,  Zhenyu Xu

IPC分类号： H04B10/071 ,  H04B10/50

CPC分类号： H04B10/071 ,  H04B10/503

摘要： Systems and methods are provided for a software defined optical time-domain reflectometer (SD-OTDR) using high-speed optical transceiver modules. Enabled by the reconfigurable computing resource, an SD-OTDR in accordance with an embodiment of the present disclosure can realize in-situ diagnostics of optical fiber without adding any overhead to existing systems. In addition, an SD-OTDR in accordance with an embodiment of the present disclosure can also be used for high-resolution distributed sensing. Additionally, an SD-OTDR in accordance with an embodiment of the present disclosure can directly map optical reflections at different locations along the length of a fiber to a processing element array in a Field-Programmable Gate Array for real-time in-sensor parallel data processing.