Invention Grant
- Patent Title: Small molecule inhibitors of MDM2 and the uses thereof
- Patent Title (中): MDM2的小分子抑制剂及其用途
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Application No.: US12822829Application Date: 2010-06-24
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Publication No.: US08088931B2Publication Date: 2012-01-03
- Inventor: Shaomeng Wang , Ke Ding , Yipin Lu , Zaneta Nikolovska-Coleska , Su Qiu , Guoping Wang , Dongguang Qin , Sanjeev Kumar
- Applicant: Shaomeng Wang , Ke Ding , Yipin Lu , Zaneta Nikolovska-Coleska , Su Qiu , Guoping Wang , Dongguang Qin , Sanjeev Kumar
- Applicant Address: US MI Ann Arbor
- Assignee: The Regents of the University of Michigan
- Current Assignee: The Regents of the University of Michigan
- Current Assignee Address: US MI Ann Arbor
- Agency: Casimir Jones SC
- Main IPC: C07D207/00
- IPC: C07D207/00
Abstract:
The invention relates to small molecules which function as inhibitors of the interaction between p53 and MDM2. The invention also relates to the use of these compounds for inhibiting cell growth, inducing cell death, inducing cell cycle arrest and/or sensitizing cells to additional agent(s).
Public/Granted literature
- US20100273799A1 SMALL MOLECULE INHIBITORS OF MDM2 AND THE USES THEREOF Public/Granted day:2010-10-28
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