公开(公告)号：US20120101092A1

公开(公告)日：2012-04-26

申请号：US13336047

申请日：2011-12-23

申请人： Shaomeng Wang ,  Ke Ding ,  Yipin Lu ,  Zaneta Nikolovska-Coleska ,  Su Qiu ,  Guoping Wang ,  Dongguang Qin ,  Sanjeev Kumar

发明人： Shaomeng Wang ,  Ke Ding ,  Yipin Lu ,  Zaneta Nikolovska-Coleska ,  Su Qiu ,  Guoping Wang ,  Dongguang Qin ,  Sanjeev Kumar

IPC分类号： A61K31/5377 ,  A61K31/407 ,  C07D413/00 ,  A61P35/00 ,  C07D487/04 ,  A61K31/4985 ,  C12N5/09 ,  C07D487/10 ,  A61K31/437

CPC分类号： C07D209/54 ,  C07D487/10 ,  C07D491/10

摘要： The invention relates to small molecules which function as inhibitors of the interaction between p53 and MDM2. The invention also relates to the use of these compounds for inhibiting cell growth, inducing cell death, inducing cell cycle arrest and/or sensitizing cells to additional agent(s).

摘要翻译： 本发明涉及作为p53和MDM2相互作用抑制剂的小分子。 本发明还涉及这些化合物用于抑制细胞生长，诱导细胞死亡，诱导细胞周期停滞和/或使细胞对附加试剂敏感的用途。

公开(公告)号：US08901117B2

公开(公告)日：2014-12-02

申请号：US13336047

申请日：2011-12-23

申请人： Shaomeng Wang ,  Ke Ding ,  Yipin Lu ,  Zaneta Nikolovska-Coleska ,  Su Qiu ,  Guoping Wang ,  Dongguang Qin ,  Sanjeev Kumar

发明人： Shaomeng Wang ,  Ke Ding ,  Yipin Lu ,  Zaneta Nikolovska-Coleska ,  Su Qiu ,  Guoping Wang ,  Dongguang Qin ,  Sanjeev Kumar

IPC分类号： A61K31/5377 ,  A61K31/407 ,  A61K31/437 ,  A61K31/4985 ,  C07D209/54 ,  C07D491/10 ,  C07D487/10

CPC分类号： C07D209/54 ,  C07D487/10 ,  C07D491/10

摘要： The invention relates to small molecules which function as inhibitors of the interaction between p53 and MDM2. The invention also relates to the use of these compounds for inhibiting cell growth, inducing cell death, inducing cell cycle arrest and/or sensitizing cells to additional agent(s).

摘要翻译： 本发明涉及作为p53和MDM2相互作用抑制剂的小分子。 本发明还涉及这些化合物用于抑制细胞生长，诱导细胞死亡，诱导细胞周期停滞和/或使细胞对附加试剂敏感的用途。

公开(公告)号：US20100273799A1

公开(公告)日：2010-10-28

申请号：US12822829

申请日：2010-06-24

申请人： Shaomeng Wang ,  Ke Ding ,  Yipin Lu ,  Zaneta Nikolovska-Coleska ,  Su Qiu ,  Guoping Wang ,  Dongguang Qin ,  Sanjeev Kumar

发明人： Shaomeng Wang ,  Ke Ding ,  Yipin Lu ,  Zaneta Nikolovska-Coleska ,  Su Qiu ,  Guoping Wang ,  Dongguang Qin ,  Sanjeev Kumar

IPC分类号： A61K31/5377 ,  A61K31/407 ,  A61P35/00 ,  C07D487/10 ,  C07D401/14 ,  A61K31/496 ,  C07D413/14 ,  C12N5/02

CPC分类号： C07D209/54 ,  C07D487/10 ,  C07D491/10

摘要： The invention relates to small molecules which function as inhibitors of the interaction between p53 and MDM2. The invention also relates to the use of these compounds for inhibiting cell growth, inducing cell death, inducing cell cycle arrest and/or sensitizing cells to additional agent(s).

摘要翻译： 本发明涉及作为p53和MDM2相互作用抑制剂的小分子。 本发明还涉及这些化合物用于抑制细胞生长，诱导细胞死亡，诱导细胞周期停滞和/或使细胞对附加试剂敏感的用途。

公开(公告)号：US20060211757A1

公开(公告)日：2006-09-21

申请号：US11360485

申请日：2006-02-22

申请人： Shaomeng Wang ,  Ke Ding ,  Yipin Lu ,  Zaneta Nikolovska-Coleska ,  Su Qiu ,  Guoping Wang ,  Dongguang Qin ,  Sanjeev Kumar

发明人： Shaomeng Wang ,  Ke Ding ,  Yipin Lu ,  Zaneta Nikolovska-Coleska ,  Su Qiu ,  Guoping Wang ,  Dongguang Qin ,  Sanjeev Kumar

IPC分类号： A61K31/407 ,  C07D209/54

CPC分类号： C07D209/54 ,  C07D487/10 ,  C07D491/10

摘要： The invention relates to small molecules which function as inhibitors of the interaction between p53 and MDM2. The invention also relates to the use of these compounds for inhibiting cell growth, inducing cell death, inducing cell cycle arrest and/or sensitizing cells to additional agent(s).

摘要翻译： 本发明涉及作为p53和MDM2相互作用抑制剂的小分子。 本发明还涉及这些化合物用于抑制细胞生长，诱导细胞死亡，诱导细胞周期停滞和/或使细胞对另外的药剂敏化的用途。

公开(公告)号：US08088931B2

公开(公告)日：2012-01-03

申请号：US12822829

申请日：2010-06-24

申请人： Shaomeng Wang ,  Ke Ding ,  Yipin Lu ,  Zaneta Nikolovska-Coleska ,  Su Qiu ,  Guoping Wang ,  Dongguang Qin ,  Sanjeev Kumar

发明人： Shaomeng Wang ,  Ke Ding ,  Yipin Lu ,  Zaneta Nikolovska-Coleska ,  Su Qiu ,  Guoping Wang ,  Dongguang Qin ,  Sanjeev Kumar

IPC分类号： C07D207/00

CPC分类号： C07D209/54 ,  C07D487/10 ,  C07D491/10

摘要： The invention relates to small molecules which function as inhibitors of the interaction between p53 and MDM2. The invention also relates to the use of these compounds for inhibiting cell growth, inducing cell death, inducing cell cycle arrest and/or sensitizing cells to additional agent(s).

摘要翻译： 本发明涉及作为p53和MDM2相互作用抑制剂的小分子。 本发明还涉及这些化合物用于抑制细胞生长，诱导细胞死亡，诱导细胞周期停滞和/或使细胞对附加试剂敏感的用途。

公开(公告)号：US07759383B2

公开(公告)日：2010-07-20

申请号：US11360485

申请日：2006-02-22

申请人： Shaomeng Wang ,  Ke Ding ,  Yipin Lu ,  Zaneta Nikolovska-Coleska ,  Su Qiu ,  Guoping Wang ,  Dongguang Qin ,  Sanjeev Kumar

发明人： Shaomeng Wang ,  Ke Ding ,  Yipin Lu ,  Zaneta Nikolovska-Coleska ,  Su Qiu ,  Guoping Wang ,  Dongguang Qin ,  Sanjeev Kumar

IPC分类号： A61K31/40 ,  C07D487/10

CPC分类号： C07D209/54 ,  C07D487/10 ,  C07D491/10

摘要： The invention relates to small molecules which function as inhibitors of the interaction between p53 and MDM2. The invention also relates to the use of these compounds for inhibiting cell growth, inducing cell death, inducing cell cycle arrest and/or sensitizing cells to additional agent(s).

摘要翻译： 本发明涉及作为p53和MDM2相互作用抑制剂的小分子。 本发明还涉及这些化合物用于抑制细胞生长，诱导细胞死亡，诱导细胞周期停滞和/或使细胞对附加试剂敏感的用途。

公开(公告)号：US08518984B2

公开(公告)日：2013-08-27

申请号：US12945511

申请日：2010-11-12

申请人： Shaomeng Wang ,  Shanghai Yu ,  Wei Sun ,  Sanjeev Kumar ,  Duxin Sun ,  Peng Zou ,  Donna McEachern ,  Yujun Zhao

发明人： Shaomeng Wang ,  Shanghai Yu ,  Wei Sun ,  Sanjeev Kumar ,  Duxin Sun ,  Peng Zou ,  Donna McEachern ,  Yujun Zhao

IPC分类号： C07D487/10 ,  A61K31/4015

CPC分类号： C07D487/10 ,  A61K31/407 ,  A61K31/454 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/675 ,  A61K45/06 ,  C07D471/20 ,  C07D491/107 ,  C07D495/10 ,  C07F9/6561 ,  A61K2300/00

摘要： Provided herein are compounds, compositions, and methods in the field of medicinal chemistry. The compounds and compositions provided herein relate to spiro-oxindoles which function as antagonists of the interaction between p53 and MDM2, and their use as therapeutics for the treatment of cancer and other diseases.

公开(公告)号：US20120122947A1

公开(公告)日：2012-05-17

申请号：US13294315

申请日：2011-11-11

申请人： Shaomeng Wang ,  Yujun Zhao ,  Wei Sun ,  Sanjeev Kumar ,  Lance Leopold ,  Laurent Debussche ,  Cedric Barriere ,  Jean-Christophe Carry ,  Kwame Amaning

发明人： Shaomeng Wang ,  Yujun Zhao ,  Wei Sun ,  Sanjeev Kumar ,  Lance Leopold ,  Laurent Debussche ,  Cedric Barriere ,  Jean-Christophe Carry ,  Kwame Amaning

IPC分类号： A61K31/407 ,  A61P35/00 ,  A61P35/02 ,  C07D487/10

CPC分类号： A61N5/10 ,  A61K31/407 ,  A61K45/06 ,  C07D487/10 ,  A61K2300/00

摘要： Provided herein are compounds, compositions, and methods in the field of medicinal chemistry. The compounds and compositions provided herein relate to spiro-oxindoles which function as antagonists of the interaction between p53 and MDM2, and their use as therapeutics for the treatment of cancer and other diseases.

摘要翻译： 本文提供了药物化学领域中的化合物，组合物和方法。 本文提供的化合物和组合物涉及用作p53和MDM2之间相互作用的拮抗剂的螺 - 羟基吲哚，以及它们作为治疗癌症和其它疾病的治疗剂的用途。

公开(公告)号：US20200221936A1

公开(公告)日：2020-07-16

申请号：US16830166

申请日：2020-03-25

申请人： Muruga Raj ,  Sanjeev Kumar

发明人： Muruga Raj ,  Sanjeev Kumar

IPC分类号： A61B1/00 ,  A61B1/015

摘要： Various embodiments include an endoscopic device. A sheath may enclose the device and may thereby guard against environmental contamination. The sheath may include one or more channels for transmission of instruments and/or solution to and from the body. The sheath may be disposable. A stopper unit may reduce fluid leakage from inside a body cavity during a procedure. The stopper unit may include a serrated outer contour to assist in catching at a body orifice. The stopper unit may have a perforable inner barrier designed to reseal about a probing portion inserted through the stopper unit.

公开(公告)号：US20170209027A1

公开(公告)日：2017-07-27

申请号：US15338408

申请日：2016-10-30

申请人： Muruga Raj ,  Sanjeev Kumar

发明人： Muruga Raj ,  Sanjeev Kumar

IPC分类号： A61B1/00 ,  A61B1/015

CPC分类号： A61B1/00137 ,  A61B1/00016 ,  A61B1/00034 ,  A61B1/00105 ,  A61B1/00108 ,  A61B1/00128 ,  A61B1/00135 ,  A61B1/00142 ,  A61B1/015

摘要： Various embodiments include an endoscopic device. A sheath may enclose the device and may thereby guard against environmental contamination. The sheath may include one or more channels for transmission of instruments and/or solution to and from the body. The sheath may be disposable. A stopper unit may reduce fluid leakage from inside a body cavity during a procedure. The stopper unit may include a serrated outer contour to assist in catching at a body orifice. The stopper unit may have a perforable inner barrier designed to reseal about a probing portion inserted through the stopper unit.