发明授权
- 专利标题： Targeting the histone code as a bacterial strategy for selectively modulating gene expression
- 专利标题（中）： 将组蛋白代码作为选择性调节基因表达的细菌策略
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申请号： US11992155申请日： 2006-09-15
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公开(公告)号： US08092989B2公开(公告)日： 2012-01-10
- 发明人: Laurence Arbibe , Philippe Sansonetti , Claude Parsot , Kim Dong Wook , Armelle Phalipon
- 申请人： Laurence Arbibe , Philippe Sansonetti , Claude Parsot , Kim Dong Wook , Armelle Phalipon
- 申请人地址： FR Paris FR Paris
- 专利权人： Institut Pasteur,Inserm (Institut National de la Sante et de la Recherche Medicale)
- 当前专利权人： Institut Pasteur,Inserm (Institut National de la Sante et de la Recherche Medicale)
- 当前专利权人地址： FR Paris FR Paris
- 代理机构： Finnegan, Henderson, Farabow, Garrett & Dunner, LLP
- 国际申请： PCT/EP2006/066406 WO 20060915
- 国际公布： WO2007/031574 WO 20070322
- 主分类号： C12Q1/00
- IPC分类号： C12Q1/00 ; C12N5/00 ; C12N5/071 ; A61K39/00 ; A61K39/38 ; A61K39/02
摘要：
The ospF gene of Shigella flexneri encodes a phosphatase, which is a member of a new class of phosphatases. The OspF phosphatase inhibits the activity of several proteins either by direct protein modification or transcription downregulation. These proteins include MAP kinase, IL-8, CCL20, IL-12, AP1, CREB, RPA p32, and BCL2 related proteins. Methods for treating diseases using OspF phosphatase, methods for identifying agents that modulate OspF phosphatase's activity, methods for identifying agents that mimic OspF phosphatase's activity, and immunogenic compositions comprising OspF phosphatase are provided. A strain of Shigella flexneri containing an inactivated ospF gene is also provided.
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