发明授权
- 专利标题： Antibody library
- 专利标题（中）： 抗体库
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申请号： US10204773申请日： 2001-02-22
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公开(公告)号： US08101553B1公开(公告)日： 2012-01-24
- 发明人: Yoshikazu Kurosawa , Yasushi Akahori , Yoshitaka Iba , Kazuhiko Morino , Midori Shinohara , Motohide Takahashi , Yoshinobu Okuno , Kimiyasu Shiraki
- 申请人： Yoshikazu Kurosawa , Yasushi Akahori , Yoshitaka Iba , Kazuhiko Morino , Midori Shinohara , Motohide Takahashi , Yoshinobu Okuno , Kimiyasu Shiraki
- 申请人地址： JP Aichi
- 专利权人： Medical & Biological Laboratories Co., Ltd.
- 当前专利权人： Medical & Biological Laboratories Co., Ltd.
- 当前专利权人地址： JP Aichi
- 代理机构： Edwards Wildman Palmer LLP
- 代理商 Peter F. Corless; Christine C. O'Day
- 优先权： JP2000-050543 20000222
- 国际申请： PCT/JP01/01298 WO 20010222
- 国际公布： WO01/62907 WO 20010830
- 主分类号： C40B50/06
- IPC分类号： C40B50/06
摘要：
An antibody library is prepared by selecting a light chain variable region capable of binding to the variable region of heavy chain to reproduce an active conformation and using the same. Because of being capable of maintaining the diversity of the heavy chain variable region at a high ratio in vitro, the antibody library of the present invention is expected as enabling the acquisition of antibodies with various binding activities.
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