公开(公告)号：US08101553B1

公开(公告)日：2012-01-24

申请号：US10204773

申请日：2001-02-22

申请人： Yoshikazu Kurosawa ,  Yasushi Akahori ,  Yoshitaka Iba ,  Kazuhiko Morino ,  Midori Shinohara ,  Motohide Takahashi ,  Yoshinobu Okuno ,  Kimiyasu Shiraki

发明人： Yoshikazu Kurosawa ,  Yasushi Akahori ,  Yoshitaka Iba ,  Kazuhiko Morino ,  Midori Shinohara ,  Motohide Takahashi ,  Yoshinobu Okuno ,  Kimiyasu Shiraki

IPC分类号： C40B50/06

CPC分类号： C12N15/10 ,  C07K16/00 ,  C07K2317/50 ,  C07K2317/56

摘要： An antibody library is prepared by selecting a light chain variable region capable of binding to the variable region of heavy chain to reproduce an active conformation and using the same. Because of being capable of maintaining the diversity of the heavy chain variable region at a high ratio in vitro, the antibody library of the present invention is expected as enabling the acquisition of antibodies with various binding activities.

摘要翻译： 通过选择能够结合重链可变区的轻链可变区以再现活性构象并使用它们来制备抗体文库。 由于能够在体外以高比例保持重链可变区的多样性，本发明的抗体文库预期能够获得具有各种结合活性的抗体。

公开(公告)号：US08003098B2

公开(公告)日：2011-08-23

申请号：US12280950

申请日：2007-02-22

申请人： Shuichi Nakatsuru ,  Megumi Yoshikawa ,  Shinichi Hiroshima ,  Yoshiro Kishi ,  Motoki Kuhara ,  Shiyo Nishida ,  Midori Shinohara

发明人： Shuichi Nakatsuru ,  Megumi Yoshikawa ,  Shinichi Hiroshima ,  Yoshiro Kishi ,  Motoki Kuhara ,  Shiyo Nishida ,  Midori Shinohara

IPC分类号： A61K39/00

CPC分类号： C07K16/2866 ,  A61K2039/505 ,  C07K2317/72 ,  C07K2317/732

摘要： The present invention relates to the use of cytoxicity based on the effector function of anti-EphA4 antibodies. Specifically, the present invention provides methods and pharmaceutical compositions that comprise an anti-EphA4 antibody as an active ingredient for damaging EphA4-expressing cells using antibody effector function. Since EphA4 is strongly expressed in pancreatic cancer cells, the present invention is particularly useful in pancreatic cancer therapies.

摘要翻译： 本发明涉及基于抗EphA4抗体的效应子功能的细胞毒性的用途。 具体而言，本发明提供了包含抗EphA4抗体作为活性成分的方法和药物组合物，用于使用抗体效应子功能损伤表达EphA4的细胞。 由于EphA4在胰腺癌细胞中强烈表达，本发明特别适用于胰腺癌治疗。