Invention Grant
US08106069B2 Pyrrolo[2,3-b]pyridine derivatives active as kinase inhibitors and pharmaceutical compositions comprising them
有权
作为激酶抑制剂活性的吡咯并[2,3-b]吡啶衍生物和包含它们的药物组合物
![Pyrrolo[2,3-b]pyridine derivatives active as kinase inhibitors and pharmaceutical compositions comprising them](/docs/US/2012-01-31/US08106069B2/abs.jpg.600x600.jpg)
- Patent Title: Pyrrolo[2,3-b]pyridine derivatives active as kinase inhibitors and pharmaceutical compositions comprising them
- Patent Title (中): 作为激酶抑制剂活性的吡咯并[2,3-b]吡啶衍生物和包含它们的药物组合物
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Application No.: US12766230Application Date: 2010-04-23
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Publication No.: US08106069B2Publication Date: 2012-01-31
- Inventor: Barbara Salom , Matteo D'Anello , Maria Gabriella Brasca , Patrizia Giordano , Katia Martina , Francesco Angelucci , Frederick Arthur Brookfield , William John Trigg , Edward Andrew Boyd , Jonathan Anthony Larard
- Applicant: Barbara Salom , Matteo D'Anello , Maria Gabriella Brasca , Patrizia Giordano , Katia Martina , Francesco Angelucci , Frederick Arthur Brookfield , William John Trigg , Edward Andrew Boyd , Jonathan Anthony Larard
- Applicant Address: IT Rome
- Assignee: Pfizer Italia S.r.l.
- Current Assignee: Pfizer Italia S.r.l.
- Current Assignee Address: IT Rome
- Agency: Scully, Scott, Murphy & Presser, P.C.
- Main IPC: A61K31/44
- IPC: A61K31/44 ; A61K31/50 ; A61K31/497 ; A61K31/445
![Pyrrolo[2,3-b]pyridine derivatives active as kinase inhibitors and pharmaceutical compositions comprising them](/abs-image/US/2012/01/31/US08106069B2/abs.jpg.150x150.jpg)
Abstract:
Compounds which are pyrrolo[2,3-b]pyridine derivatives or pharmaceutically acceptable salts thereof, their preparation process and pharmaceutical compositions comprising them are disclosed; these compounds are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, cell proliferative disorders, Alzheimer's disease, viral infections, auto-immune diseases and neurodegenerative disorders; also disclosed is a process under SPS conditions for preparing the compounds of the invention and chemical libraries comprising a plurality of them.
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