公开(公告)号：US20120207712A1

公开(公告)日：2012-08-16

申请号：US13179712

申请日：2011-07-11

申请人： Valeria Longoni ,  Marisa Penci

发明人： Valeria Longoni ,  Marisa Penci

IPC分类号： A61K35/74 ,  A23L1/308 ,  A23L1/304 ,  A61P1/00 ,  A23L1/30

CPC分类号： A61K35/745 ,  A23L33/135 ,  A23L33/16 ,  A23L33/19 ,  A23L33/21 ,  A23V2002/00 ,  A61K9/0095 ,  A61K35/747 ,  A61K36/064 ,  A61K38/063 ,  A61K38/40 ,  A61K47/02 ,  A61K47/183 ,  A61K47/26 ,  A61K47/36 ,  A61K47/42 ,  A61K2035/11 ,  A61K38/06

摘要： The present invention relates to compositions comprising probiotic and prebiotic components, mineral salts, lactoferrin, and possibly saccharomycetes, which perform correct, effective colonisation of the probiotic components administered, with enteric consequences which involve maintaining and/or restoring intestinal health and preventing the consequences of common dysbioses of the digestive tract caused by stress, incorrect dietary habits and antibiotic treatments. Said compositions also have a concomitant anti-inflammatory and immunomodulating action.

摘要翻译： 本发明涉及包含益生菌和益生元组分，矿物盐，乳铁蛋白和可能的酵母菌的组合物，其对所施用的益生菌成分进行正确的，有效的定植，其包括维持和/或恢复肠道健康并防止其后果 由压力引起的消化道常见的生殖器异常，饮食习惯不正确和抗生素治疗。 所述组合物还具有伴随的抗炎和免疫调节作用。

公开(公告)号：US20090233813A1

公开(公告)日：2009-09-17

申请号：US12472513

申请日：2009-05-27

申请人： Roberto Tonani ,  Simona Bindi ,  Daniele Fancelli ,  Valeria Pittala' ,  Mario Varasi

发明人： Roberto Tonani ,  Simona Bindi ,  Daniele Fancelli ,  Valeria Pittala' ,  Mario Varasi

IPC分类号： C40B40/14 ,  C40B40/04

CPC分类号： C07D487/04 ,  C07D491/04 ,  C07D495/04

摘要： Bicyclo-pyrazole compound of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, processes for their preparation, combinatorial libraries comprising a plurality of them and pharmaceutical compositions thereof, are herewith disclosed: the compounds of the invention are useful, in therapy, as protein kinase inhibitors, for instance in the treatment of cancer.

摘要翻译： 本说明书中定义的式（I）的双 - 吡唑化合物及其药学上可接受的盐，其制备方法，包含其中的多个组合文库及其药物组合物，本文公开了本发明的化合物， 在治疗中，作为蛋白激酶抑制剂，例如用于治疗癌症。

公开(公告)号：US07371862B2

公开(公告)日：2008-05-13

申请号：US11271191

申请日：2005-11-11

申请人： Ermes Vanotti ,  Francesco Angelucci ,  Alberto Bargiotti ,  Maria Gabriella Brasca ,  Antonella Ermoli ,  Maria Menichincheri

发明人： Ermes Vanotti ,  Francesco Angelucci ,  Alberto Bargiotti ,  Maria Gabriella Brasca ,  Antonella Ermoli ,  Maria Menichincheri

IPC分类号： C07D471/02 ,  C07D233/00

CPC分类号： C07D471/04

摘要： The present invention is directed to compounds of the formula or pharmaceutically acceptable salts, prodrug, solvate or optical isomer thereof, pharmaceutical compositions containing same and use thereof for treating diseases linked to disregulated cell proliferation or to disregulated protein kinase.

摘要翻译： 本发明涉及下式的化合物或其药学上可接受的盐，前体药物，溶剂合物或旋光异构体，含有该化合物的药物组合物及其用于治疗与细胞增殖失调或失调的蛋白激酶相关的疾病的用途。

公开(公告)号：US20060276471A1

公开(公告)日：2006-12-07

申请号：US11503256

申请日：2006-08-11

申请人： Daniele Fancelli ,  Barbara Forte ,  Jurgen Moll ,  Mario Varasi ,  Paola Vianello

发明人： Daniele Fancelli ,  Barbara Forte ,  Jurgen Moll ,  Mario Varasi ,  Paola Vianello

IPC分类号： A61K31/5377 ,  A61K31/496 ,  A61K31/454 ,  C07D487/02

CPC分类号： C07D487/04

摘要： Pyrrolo[3,4-c]pyrazole derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.

公开(公告)号：US07105535B2

公开(公告)日：2006-09-12

申请号：US10470859

申请日：2002-01-28

申请人： Daniela Berta ,  Eduard Felder ,  Anna Vulpetti ,  Marzia Villa

发明人： Daniela Berta ,  Eduard Felder ,  Anna Vulpetti ,  Marzia Villa

IPC分类号： A61K31/302 ,  A61K31/338 ,  A61K31/375 ,  C07D471/04 ,  C07D471/06

CPC分类号： C07D413/04 ,  A61K31/4155 ,  A61K31/437 ,  C07D413/14

摘要： Compounds which are oxazolyl-pyrazole derivatives, as defined in the specification, and pharmaceutically acceptable salts thereof; are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, cell proliferative disorders, viral infections, autoimmune diseases and neurodegenerative disorders.

摘要翻译： 化合物，如说明书中所定义的恶唑基 - 吡唑衍生物及其药学上可接受的盐; 可用于治疗由改变的蛋白激酶活性如癌症，细胞增殖性病症，病毒感染，自身免疫性疾病和神经变性疾病引起的和/或与其相关的疾病。

公开(公告)号：US20170216373A1

公开(公告)日：2017-08-03

申请号：US15485809

申请日：2017-04-12

申请人： Pfizer Italia S.r.L.

发明人： Valeria Longoni ,  Marisa Penci

IPC分类号： A61K35/745 ,  A61K47/42 ,  A61K47/02 ,  A61K47/36 ,  A23L33/21 ,  A61K36/064 ,  A23L33/135 ,  A23L33/16 ,  A23L33/19 ,  A61K35/747 ,  A61K47/26

CPC分类号： A61K35/745 ,  A23L33/135 ,  A23L33/16 ,  A23L33/19 ,  A23L33/21 ,  A23V2002/00 ,  A61K9/0095 ,  A61K35/747 ,  A61K36/064 ,  A61K38/063 ,  A61K38/40 ,  A61K47/02 ,  A61K47/183 ,  A61K47/26 ,  A61K47/36 ,  A61K47/42 ,  A61K2035/11 ,  A61K38/06

摘要： The present invention relates to compositions comprising probiotic and prebiotic components, mineral salts, lactoferrin, and possibly saccharomycetes, which perform correct, effective colonisation of the probiotic components administered, with enteric consequences which involve maintaining and/or restoring intestinal health and preventing the consequences of common dysbioses of the digestive tract caused by stress, incorrect dietary habits and antibiotic treatments. Said compositions also have a concomitant anti-inflammatory and immunomodulating action.

公开(公告)号：US09649380B2

公开(公告)日：2017-05-16

申请号：US13179712

申请日：2011-07-11

申请人： Valeria Longoni ,  Marisa Penci

发明人： Valeria Longoni ,  Marisa Penci

IPC分类号： A61K35/74 ,  A61K47/02 ,  A61K35/745 ,  A61K35/747 ,  A61K38/06 ,  A61K38/40 ,  A61K47/18 ,  A61K9/00 ,  A61K47/26 ,  A61K47/42 ,  A23L33/135 ,  A23L33/16 ,  A23L33/19 ,  A23L33/21

CPC分类号： A61K35/745 ,  A23L33/135 ,  A23L33/16 ,  A23L33/19 ,  A23L33/21 ,  A23V2002/00 ,  A61K9/0095 ,  A61K35/747 ,  A61K36/064 ,  A61K38/063 ,  A61K38/40 ,  A61K47/02 ,  A61K47/183 ,  A61K47/26 ,  A61K47/36 ,  A61K47/42 ,  A61K2035/11 ,  A61K38/06

摘要： The present invention relates to compositions comprising probiotic and prebiotic components, mineral salts, lactoferrin, and possibly saccharomycetes, which perform correct, effective colonisation of the probiotic components administered, with enteric consequences which involve maintaining and/or restoring intestinal health and preventing the consequences of common dysbioses of the digestive tract caused by stress, incorrect dietary habits and antibiotic treatments. Said compositions also have a concomitant anti-inflammatory and immunomodulating action.

公开(公告)号：US08106069B2

公开(公告)日：2012-01-31

申请号：US12766230

申请日：2010-04-23

申请人： Barbara Salom ,  Matteo D'Anello ,  Maria Gabriella Brasca ,  Patrizia Giordano ,  Katia Martina ,  Francesco Angelucci ,  Frederick Arthur Brookfield ,  William John Trigg ,  Edward Andrew Boyd ,  Jonathan Anthony Larard

发明人： Barbara Salom ,  Matteo D'Anello ,  Maria Gabriella Brasca ,  Patrizia Giordano ,  Katia Martina ,  Francesco Angelucci ,  Frederick Arthur Brookfield ,  William John Trigg ,  Edward Andrew Boyd ,  Jonathan Anthony Larard

IPC分类号： A61K31/44 ,  A61K31/50 ,  A61K31/497 ,  A61K31/445

CPC分类号： C07D471/04

摘要： Compounds which are pyrrolo[2,3-b]pyridine derivatives or pharmaceutically acceptable salts thereof, their preparation process and pharmaceutical compositions comprising them are disclosed; these compounds are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, cell proliferative disorders, Alzheimer's disease, viral infections, auto-immune diseases and neurodegenerative disorders; also disclosed is a process under SPS conditions for preparing the compounds of the invention and chemical libraries comprising a plurality of them.

摘要翻译： 公开了吡咯并[2,3-b]吡啶衍生物或其药学上可接受的盐的化合物，其制备方法和包含它们的药物组合物; 这些化合物可用于治疗由改变的蛋白激酶活性如癌症，细胞增殖性疾病，阿尔茨海默病，病毒感染，自身免疫疾病和神经变性疾病引起的和/或与其相关的疾病。 还公开了在SPS条件下制备本发明化合物的方法和包含其中多个化合物的化学文库。

公开(公告)号：US07531531B2

公开(公告)日：2009-05-12

申请号：US11784980

申请日：2007-04-10

申请人： Daniele Fancelli ,  Valeria Pittalà ,  Mario Varasi

发明人： Daniele Fancelli ,  Valeria Pittalà ,  Mario Varasi

IPC分类号： A61K31/55 ,  A61K31/501 ,  A61K31/437 ,  A61K31/426

CPC分类号： C07D487/04 ,  C07D471/04 ,  C40B40/00

摘要： Bicyclo-pyrazole compounds of formula (I), as herein defined, are useful for treating diseases linked to disregulated protein kinases.

摘要翻译： 如本文所定义的式（I）的双 - 吡唑化合物可用于治疗与失调的蛋白激酶相关的疾病。

公开(公告)号：US07462643B1

公开(公告)日：2008-12-09

申请号：US09869333

申请日：2000-02-07

申请人： Franco Pamparana

发明人： Franco Pamparana

IPC分类号： A61K31/22 ,  A61K31/20

CPC分类号： A61K31/23 ,  A61K31/231 ,  A61K31/232 ,  A61K2300/00

摘要： The invention concerns the use of essential fatty acids with a high content in eicosapentaenoic acid ethyl ester (EPA) or docosahexaenoic acid ethyl ester (DHA) or a high concentration mixture thereof in the preparation of a medicament useful for preventing mortality, in particular due to sudden death, in patients who have suffered from a myocardial infarction.

摘要翻译： 本发明涉及在二十碳五烯酸乙酯（EPA）或二十二碳六烯酸乙酯（DHA）或其高浓度混合物中具有高含量的必需脂肪酸的用途，用于制备用于预防死亡的药物，特别是由于 在心肌梗死患者中突然死亡。