发明授权
- 专利标题: Human anti-KIR antibodies
- 专利标题(中): 人抗KIR抗体
-
申请号: US12244170申请日: 2008-10-02
-
公开(公告)号: US08119775B2公开(公告)日: 2012-02-21
- 发明人: Alessandro Moretta , Mariella Della Chiesa , Pascale Andre , Laurent Gauthier , Francois Romagné , Peter Andreas Nicolai Reumert Wagtmann , Ivan Svendsen , Stefan Zahn , Anders Svensson , Matthias Thórólfsson , Søren Berg Padkær , Kristian Kjaergaard , Pieter Spee , Michael Wilken
- 申请人: Alessandro Moretta , Mariella Della Chiesa , Pascale Andre , Laurent Gauthier , Francois Romagné , Peter Andreas Nicolai Reumert Wagtmann , Ivan Svendsen , Stefan Zahn , Anders Svensson , Matthias Thórólfsson , Søren Berg Padkær , Kristian Kjaergaard , Pieter Spee , Michael Wilken
- 申请人地址: IT Genoa FR Marseilles DK Bagsvaerd
- 专利权人: University of Genoa,Innate Pharma S.A.S.,Novo Nordisk A/S
- 当前专利权人: University of Genoa,Innate Pharma S.A.S.,Novo Nordisk A/S
- 当前专利权人地址: IT Genoa FR Marseilles DK Bagsvaerd
- 代理机构: Hunton & Williams LLP
- 优先权: WOPCT/DK2004/000470 20040701; WOPCT/IB2004/002464 20040701; DK200500025 20050106
- 主分类号: C12P21/08
- IPC分类号: C12P21/08 ; C07K16/00
摘要:
Compositions and methods for regulating an immune response in a subject are described. More particularly, described are human antibodies that regulate the activity of NK cells and allow a potentiation of NK cell cytotoxicity in mammalian subjects, and antibodies having antigen-binding properties similar to those of human monoclonal antibody 1-7F9 or 1-4F1. Described also are also fragments and derivatives of such antibodies, as well as pharmaceutical compositions comprising the same and their uses, particularly for use in therapy, to increase NK cell activity or cytotoxicity in subjects.
公开/授权文献
- US20090081240A1 Human Anti-Kir Antibodies 公开/授权日:2009-03-26