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公开(公告)号:US08119775B2
公开(公告)日:2012-02-21
申请号:US12244170
申请日:2008-10-02
申请人: Alessandro Moretta , Mariella Della Chiesa , Pascale Andre , Laurent Gauthier , Francois Romagné , Peter Andreas Nicolai Reumert Wagtmann , Ivan Svendsen , Stefan Zahn , Anders Svensson , Matthias Thórólfsson , Søren Berg Padkær , Kristian Kjaergaard , Pieter Spee , Michael Wilken
发明人: Alessandro Moretta , Mariella Della Chiesa , Pascale Andre , Laurent Gauthier , Francois Romagné , Peter Andreas Nicolai Reumert Wagtmann , Ivan Svendsen , Stefan Zahn , Anders Svensson , Matthias Thórólfsson , Søren Berg Padkær , Kristian Kjaergaard , Pieter Spee , Michael Wilken
CPC分类号: C07K16/42 , C07K16/28 , C07K16/2803 , C07K2299/00 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要: Compositions and methods for regulating an immune response in a subject are described. More particularly, described are human antibodies that regulate the activity of NK cells and allow a potentiation of NK cell cytotoxicity in mammalian subjects, and antibodies having antigen-binding properties similar to those of human monoclonal antibody 1-7F9 or 1-4F1. Described also are also fragments and derivatives of such antibodies, as well as pharmaceutical compositions comprising the same and their uses, particularly for use in therapy, to increase NK cell activity or cytotoxicity in subjects.
摘要翻译: 描述了用于调节受试者的免疫应答的组合物和方法。 更具体地,描述了调节NK细胞活性并允许在哺乳动物受试者中增强NK细胞细胞毒性的人抗体,以及具有与人单克隆抗体1-7F9或1-4F1类似的抗原结合特性的抗体。 还描述了这种抗体的片段和衍生物,以及包含其的药物组合物及其用途,特别是用于治疗,以增加受试者的NK细胞活性或细胞毒性。
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公开(公告)号:US20090081240A1
公开(公告)日:2009-03-26
申请号:US12244170
申请日:2008-10-02
申请人: Alessandro Moretta , Mariella Della Chiesa , Pascale Andre , Laurent Gauthier , Francois Romagne , Peter Andreas Nicolai Reumert Wagtmann , Ivan Svendsen , Stefan Zahn , Anders Svensson , Matthias Thorolfsson , Soren Berg Padkaer , Kristian Kjaergaard , Pieter Spee , Michael Wilken
发明人: Alessandro Moretta , Mariella Della Chiesa , Pascale Andre , Laurent Gauthier , Francois Romagne , Peter Andreas Nicolai Reumert Wagtmann , Ivan Svendsen , Stefan Zahn , Anders Svensson , Matthias Thorolfsson , Soren Berg Padkaer , Kristian Kjaergaard , Pieter Spee , Michael Wilken
CPC分类号: C07K16/42 , C07K16/28 , C07K16/2803 , C07K2299/00 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要: Compositions and methods for regulating an immune response in a subject are described. More particularly, described are human antibodies that regulate the activity of NK cells and allow a potentiation of NK cell cytotoxicity in mammalian subjects, and antibodies having antigen-binding properties similar to those of human monoclonal antibody 1-7F9 or 1-4F1. Described also are also fragments and derivatives of such antibodies, as well as pharmaceutical compositions comprising the same and their uses, particularly for use in therapy, to increase NK cell activity or cytotoxicity in subjects.
摘要翻译: 描述了用于调节受试者的免疫应答的组合物和方法。 更具体地,描述了调节NK细胞活性并允许哺乳动物受试者中NK细胞细胞毒性增强的抗体,以及具有与人单克隆抗体1-7F9或1-4F1类似的抗原结合特性的抗体。 还描述了这种抗体的片段和衍生物,以及包含其的药物组合物及其用途,特别是用于治疗,以增加受试者的NK细胞活性或细胞毒性。
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公开(公告)号:US09505684B2
公开(公告)日:2016-11-29
申请号:US13697825
申请日:2011-04-21
申请人: Hermann Bach , Thomas Renner , Martin Rothaemel , Michael Wilken
发明人: Hermann Bach , Thomas Renner , Martin Rothaemel , Michael Wilken
摘要: A process and a plant for producing an olefin stream from a hydrocarbon mixture feed stream, wherein the olefin stream is depleted as regards its content of oxygen-containing organic compounds (oxygenates) as compared to the feed stream. The hydrocarbon mixture feed stream is charged to a separation column operated by a thermal separation process, for example to a distillation column, wherein a material stream enriched in oxygenates is withdrawn via a side outlet and removed from the process. The process according to the invention is particularly useful for processing the product streams obtained in the olefin synthesis by an OTO process.
摘要翻译: 一种用于从烃混合物进料流中生产烯烃流的方法和设备,其中与进料流相比,烯烃流的含量与含氧有机化合物(含氧化合物)的含量相同。 将烃混合物进料流加入到通过热分离过程操作的分离塔中,例如加入到蒸馏塔中,其中富含含氧化合物的物料流通过侧出口排出并从该方法中除去。 根据本发明的方法特别适用于通过OTO方法处理在烯烃合成中获得的产物流。
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公开(公告)号:US20130060073A1
公开(公告)日:2013-03-07
申请号:US13697825
申请日:2011-04-21
申请人: Hermann Bach , Thomas Renner , Martin Rothaemel , Michael Wilken
发明人: Hermann Bach , Thomas Renner , Martin Rothaemel , Michael Wilken
摘要: A process and a plant for producing an olefin stream from a hydrocarbon mixture feed stream, wherein the olefin stream is depleted as regards its content of oxygen-containing organic compounds (oxygenates) as compared to the feed stream. The hydrocarbon mixture feed stream is charged to a separation column operated by a thermal separation process, for example to a distillation column, wherein a material stream enriched in oxygenates is withdrawn via a side outlet and removed from the process. The process according to the invention is particularly useful for processing the product streams obtained in the olefin synthesis by an OTO process.
摘要翻译: 一种用于从烃混合物进料流中生产烯烃流的方法和设备,其中与进料流相比,烯烃流的含量与含氧有机化合物(含氧化合物)的含量相同。 将烃混合物进料流加入到通过热分离过程操作的分离塔中,例如加入到蒸馏塔中,其中富含含氧化合物的物料流通过侧出口排出并从该方法中除去。 根据本发明的方法特别适用于通过OTO方法处理在烯烃合成中获得的产物流。
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公开(公告)号:US20120208237A1
公开(公告)日:2012-08-16
申请号:US13347832
申请日:2012-01-11
申请人: Alessandro Moretta , Mariella Della Chiesa , Pascale Andre , Laurent Gauthier , Francois Romagné , Peter Andreas Nicolai Reumert Wagtmann , Ivan Svendsen , Stefan Zahn , Anders Svensson , Matthias Thórólfsson , Søren Berg Padkær , Kristian Kjaergaard , Pieter Spee , Michael Wilken
发明人: Alessandro Moretta , Mariella Della Chiesa , Pascale Andre , Laurent Gauthier , Francois Romagné , Peter Andreas Nicolai Reumert Wagtmann , Ivan Svendsen , Stefan Zahn , Anders Svensson , Matthias Thórólfsson , Søren Berg Padkær , Kristian Kjaergaard , Pieter Spee , Michael Wilken
CPC分类号: C07K16/42 , C07K16/28 , C07K16/2803 , C07K2299/00 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要: Compositions and methods for regulating an immune response in a subject are described. More particularly, described are human antibodies that regulate the activity of NK cells and allow a potentiation of NK cell cytotoxicity in mammalian subjects, and antibodies having antigen-binding properties similar to those of human monoclonal antibody 1-7F9 or 1-4F1. Described also are also fragments and derivatives of such antibodies, as well as pharmaceutical compositions comprising the same and their uses, particularly for use in therapy, to increase NK cell activity or cytotoxicity in subjects.
摘要翻译: 描述了用于调节受试者的免疫应答的组合物和方法。 更具体地,描述了调节NK细胞活性并允许在哺乳动物受试者中增强NK细胞细胞毒性的人抗体,以及具有与人单克隆抗体1-7F9或1-4F1类似的抗原结合特性的抗体。 还描述了这种抗体的片段和衍生物,以及包含其的药物组合物及其用途,特别是用于治疗,以增加受试者的NK细胞活性或细胞毒性。
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