发明授权
- 专利标题： Preparation of opiate analgesics by reductive alkylation
- 专利标题（中）： 通过还原烷基化制备鸦片止痛药
-
申请号： US11628210申请日： 2005-09-14
-
公开(公告)号： US08119803B2公开(公告)日： 2012-02-21
- 发明人: Melville Mitchell , Neil Kenneth Thomson , George Scott Wilson , Neil John Goodwin , Maureen Joan Young
- 申请人： Melville Mitchell , Neil Kenneth Thomson , George Scott Wilson , Neil John Goodwin , Maureen Joan Young
- 申请人地址： GB London
- 专利权人： Johnson Matthey Public Limited Company
- 当前专利权人： Johnson Matthey Public Limited Company
- 当前专利权人地址： GB London
- 代理机构： RatnerPrestia
- 优先权： GB0421687.5 20040930
- 国际申请： PCT/GB2005/003547 WO 20050914
- 国际公布： WO2006/035195 WO 20060406
- 主分类号： C07D489/02
- IPC分类号： C07D489/02 ; C07D489/08
摘要：
A process for preparing a compound of formula (A), (B) or (C): wherein P is H, CH3 or a hydroxyl protecting group; X is O, a protected ketone, OH, a protected hydroxyl group or H; Y is OH, a protected hydroxyl group or H; W is C(CH3)2OH, (CH3)(C(CH3)3)OH or COCH3; Z is C2-C10 alkyl or C2-C10 arylalkyl; and is a single bond or a double bond, is disclosed. The process includes reductive alkylation in the presence of hydrogen and a reductive alkylation catalyst.
公开/授权文献
- US20080045715A1 Preparation of Opiate Analgesics by Reductive Alkylation 公开/授权日：2008-02-21
信息查询
