Invention Grant
- Patent Title: Benzimidazole compound
- Patent Title (中): 苯并咪唑化合物
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Application No.: US12189590Application Date: 2008-08-11
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Publication No.: US08124780B2Publication Date: 2012-02-28
- Inventor: Shuhei Miyazawa , Masanobu Shinoda , Tetsuya Kawahara , Nobuhisa Watanabe , Hitoshi Harada , Daisuke Iida , Hiroki Terauchi , Junichi Nagakawa , Hideaki Fujisaki , Atsuhiko Kubota , Masato Ueda
- Applicant: Shuhei Miyazawa , Masanobu Shinoda , Tetsuya Kawahara , Nobuhisa Watanabe , Hitoshi Harada , Daisuke Iida , Hiroki Terauchi , Junichi Nagakawa , Hideaki Fujisaki , Atsuhiko Kubota , Masato Ueda
- Applicant Address: JP Tokyo
- Assignee: Eisai R&D Management Co., Ltd.
- Current Assignee: Eisai R&D Management Co., Ltd.
- Current Assignee Address: JP Tokyo
- Agency: Birch, Stewart, Kolasch & Birch, LLP
- Priority: JP2005-117643 20050415
- Main IPC: C07D401/12
- IPC: C07D401/12

Abstract:
A novel chemical compound useful as a therapeutic or prophylactic agent for acid-related diseases is provided, which has an excellent inhibitory effect against gastric acid secretion, an excellent effect of maintaining the inhibitory effect against gastric acid secretion, thereby maintaining intragastric pH high for a long time, and having more safety and appropriate physicochemical stability. Provided is a compound represented by where R1 and R3 may be the same or different and each represent a hydrogen atom or a C1-C6 alkyl group; R2 represents (5,5-dimethyl-1,3-dioxan-2-yl)methoxy group, 5,7-dioxaspiro[2.5]oct-6-ylmethoxy group, 1,5,9-trioxaspiro[5.5]undec-3-ylmethoxy group, or (2,2-dimethyl-1,3-dioxan-5-yl)methoxy group; R4, R5, R6 and R7 represent a hydrogen atom, halogen atom, C1-C6 alkyl group, C1-C6 haloalkyl group, C1-C6 alkoxy group or C1-C6 haloalkoxy group; and W1 represents a single bond, methylene or ethylene group, a salt thereof or a solvate of these.
Public/Granted literature
- US20090203911A1 BENZIMIDAZOLE COMPOUND Public/Granted day:2009-08-13
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