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    BENZIMIDAZOLE COMPOUND
    1.
    发明申请
    BENZIMIDAZOLE COMPOUND 有权
    苯并咪唑化合物

    公开(公告)号：US20090203911A1

    公开(公告)日：2009-08-13

    申请号：US12189590

    申请日：2008-08-11

    申请人： Shuhei MIYAZAWA ,  Masanobu Shinoda ,  Tetsuya Kawahara ,  Nobuhisa Watanabe ,  Hitoshi Harada ,  Daisuke Iida ,  Hiroki Terauchi ,  Junichi Nagakawa ,  Hideaki Fujisaki ,  Atsuhiko Kubota ,  Masato Ueda

    发明人： Shuhei MIYAZAWA ,  Masanobu Shinoda ,  Tetsuya Kawahara ,  Nobuhisa Watanabe ,  Hitoshi Harada ,  Daisuke Iida ,  Hiroki Terauchi ,  Junichi Nagakawa ,  Hideaki Fujisaki ,  Atsuhiko Kubota ,  Masato Ueda

    IPC分类号： C07D405/14 ,  C07D401/12

    CPC分类号： C07D491/04 ,  C07D405/14 ,  C07D493/08 ,  C07D493/10

    摘要： A novel chemical compound useful as a therapeutic or prophylactic agent for acid-related diseases is provided, which has an excellent inhibitory effect against gastric acid secretion, an excellent effect of maintaining the inhibitory effect against gastric acid secretion, thereby maintaining intragastric pH high for a long time, and having more safety and appropriate physicochemical stability. Provided is a compound represented by where R1 and R3 may be the same or different and each represent a hydrogen atom or a C1-C6 alkyl group; R2 represents (5,5-dimethyl-1,3-dioxan-2-yl)methoxy group, 5,7-dioxaspiro[2.5]oct-6-ylmethoxy group, 1,5,9-trioxaspiro[5.5]undec-3-ylmethoxy group, or (2,2-dimethyl-1,3-dioxan-5-yl)methoxy group; R4, R5, R6 and R7 represent a hydrogen atom, halogen atom, C1-C6 alkyl group, C1-C6 haloalkyl group, C1-C6 alkoxy group or C1-C6 haloalkoxy group; and W1 represents a single bond, methylene or ethylene group, a salt thereof or a solvate of these.

    摘要翻译： 提供了可用作酸性相关疾病的治疗或预防剂的新型化合物，其对胃酸分泌具有优异的抑制作用，保持对胃酸分泌的抑制作用的优异效果，从而保持胃内pH高 长时间，具有更多的安全性和适当的物理化学稳定性。 提供一种化合物，其中R 1和R 3可以相同或不同，各自表示氢原子或C 1 -C 6烷基; R2代表（5,5-二甲基-1,3-二恶烷-2-基）甲氧基，5,7-二氧杂螺[2.5]辛-6-基甲氧基，1,5,9-三氧杂螺[5.5]十一烷-3 - 甲氧基或（2,2-二甲基-1,3-二恶烷-5-基）甲氧基; R4，R5，R6和R7表示氢原子，卤素原子，C1-C6烷基，C1-C6卤代烷基，C1-C6烷氧基或C1-C6卤代烷氧基; W1表示单键，亚甲基或亚乙基，它们的盐或它们的溶剂合物。

    Chromogenic 1-(3-methoxy-4-alkoxyphenyl)-2-(2'-quinolyl)ethylene compounds
    5.
    发明授权
    Chromogenic 1-(3-methoxy-4-alkoxyphenyl)-2-(2'-quinolyl)ethylene compounds 失效
    显色1-（3-甲氧基-4-烷氧基苯基）-2-（2'-喹啉基）乙烯化合物

    公开(公告)号：US4598150A

    公开(公告)日：1986-07-01

    申请号：US580604

    申请日：1984-02-16

    申请人： Hideaki Fujisaki ,  Seiichi Nieda ,  Katsuhiko Tsunemitsu

    发明人： Hideaki Fujisaki ,  Seiichi Nieda ,  Katsuhiko Tsunemitsu

    IPC分类号： B41M5/136 ,  B41M5/323 ,  C07D215/14 ,  C07D215/18 ,  C07D215/20

    CPC分类号： C07D215/20 ,  B41M5/136 ,  B41M5/323 ,  C07D215/14 ,  C07D215/18

    摘要： The present invention relates to a novel compound of the formula: ##STR1## wherein R.sup.1 and R.sup.2 respectively represent hydrogen atom, lower alkyl group of 1 to 5 carbon atoms, lower alkoxy group of 1 to 5 carbon atoms or halogen atom; R.sup.3 represents hydrogen atom, alkyl group of 1 to 12 carbon atoms, alkoxyalkyl group of 1 to 12 carbon atoms, halogenoalkyl group of 1 to 12 carbon atoms, phenyl group which may be substituted or benzyl group which may be substituted; and m and n are an integer of 1 or 2; providing the R.sup.1 and R.sup.2 do not represent hydrogen atom, methyl group and methoxy group when R.sup.3 represents hydrogen atom or methyl group.Further, the present invention relates to color developing compositions suitable for use in a recording material and pressure- or heat-sensitive recording sheet containing the novel compound of the formula (I).

    摘要翻译： 本发明涉及下式的新型化合物：其中R 1和R 2分别表示氢原子，1至5个碳原子的低级烷基，1至5个碳原子的低级烷氧基或卤原子; R3表示氢原子，1〜12个碳原子的烷基，1〜12个碳原子的烷氧基烷基，1〜12个碳原子的卤代烷基，可被取代的苯基或可被取代的苄基; m和n为1或2的整数; 当R3表示氢原子或甲基时，R1和R2不表示氢原子，甲基和甲氧基。 此外，本发明涉及适用于含有式（I）的新型化合物的记录材料和压敏或热敏记录片材的彩色显影组合物。

    Benzimidazole compound
    10.
    发明授权
    Benzimidazole compound 有权
    苯并咪唑化合物

    公开(公告)号：US07425634B2

    公开(公告)日：2008-09-16

    申请号：US11520838

    申请日：2006-09-14

    申请人： Shuhei Miyazawa ,  Masanobu Shinoda ,  Tetsuya Kawahara ,  Nobuhisa Watanabe ,  Hitoshi Harada ,  Daisuke Iida ,  Hiroki Terauchi ,  Junichi Nagakawa ,  Hideaki Fujisaki ,  Atsuhiko Kubota ,  Masato Ueda

    发明人： Shuhei Miyazawa ,  Masanobu Shinoda ,  Tetsuya Kawahara ,  Nobuhisa Watanabe ,  Hitoshi Harada ,  Daisuke Iida ,  Hiroki Terauchi ,  Junichi Nagakawa ,  Hideaki Fujisaki ,  Atsuhiko Kubota ,  Masato Ueda

    IPC分类号： C07D401/12

    CPC分类号： C07D491/04 ,  C07D405/14 ,  C07D493/08 ,  C07D493/10

    摘要： An object of the present invention is to provide a novel chemical compound useful as a therapeutic or prophylactic agent for acid-related diseases, having an excellent inhibitory effect against gastric acid secretion, an excellent effect of maintaining the inhibitory effect against gastric acid secretion, thereby maintaining intragastric pH high for a long time, and having more safety and appropriate physicochemical stability.Provided is a compound represented by where R1 and R3 may be the same or different and each represent a hydrogen atom or a C1-C6 alkyl group; R2 represents (5,5-dimethyl-1,3-dioxan-2-yl)methoxy group, 5,7-dioxaspiro[2.5]oct-6-ylmethoxy group, 1,5,9-trioxaspiro[5.5]undec-3-ylmethoxy group, or (2,2-dimethyl-1,3-dioxan-5-yl)methoxy group; R4, R5, R6 and R7 represent a hydrogen atom, halogen atom, C1-C6 alkyl group, C1-C6 haloalkyl group, C1-C6 alkoxy group or C1-C6 haloalkoxy group; and W1 represents a single bond, methylene or ethylene group, a salt thereof or a solvate of these.

    摘要翻译： 本发明的目的是提供一种新颖的化合物，其可用作酸性相关疾病的治疗或预防剂，对胃酸分泌具有优异的抑制作用，具有保持对胃酸分泌的抑制作用的优异效果，从而 长时间保持胃内pH高，并具有更多的安全性和适当的物理化学稳定性。 其中R 1和R 3可以相同或不同，表示氢原子或C1-C6烷基; R 5表示（5,5-二甲基-1,3-二恶烷-2-基）甲氧基，5,7-二氧杂螺[2.5]辛-6-基甲氧基，1,5,9 - 三氧杂螺[5.5]十一烷-3-基甲氧基或（2,2-二甲基-1,3-二恶烷-5-基）甲氧基; R 4，R 5，R 6和R 7表示氢原子，卤素原子，C 1 -C 6 烷基，C1-C6卤代烷基，C1-C6烷氧基或C1-C6卤代烷氧基; 和W 1表示单键，亚甲基或亚乙基，其盐或它们的溶剂合物。