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    BENZIMIDAZOLE COMPOUND
    1.
    发明申请
    BENZIMIDAZOLE COMPOUND 有权
    苯并咪唑化合物

    公开(公告)号：US20090203911A1

    公开(公告)日：2009-08-13

    申请号：US12189590

    申请日：2008-08-11

    申请人： Shuhei MIYAZAWA ,  Masanobu Shinoda ,  Tetsuya Kawahara ,  Nobuhisa Watanabe ,  Hitoshi Harada ,  Daisuke Iida ,  Hiroki Terauchi ,  Junichi Nagakawa ,  Hideaki Fujisaki ,  Atsuhiko Kubota ,  Masato Ueda

    发明人： Shuhei MIYAZAWA ,  Masanobu Shinoda ,  Tetsuya Kawahara ,  Nobuhisa Watanabe ,  Hitoshi Harada ,  Daisuke Iida ,  Hiroki Terauchi ,  Junichi Nagakawa ,  Hideaki Fujisaki ,  Atsuhiko Kubota ,  Masato Ueda

    IPC分类号： C07D405/14 ,  C07D401/12

    CPC分类号： C07D491/04 ,  C07D405/14 ,  C07D493/08 ,  C07D493/10

    摘要： A novel chemical compound useful as a therapeutic or prophylactic agent for acid-related diseases is provided, which has an excellent inhibitory effect against gastric acid secretion, an excellent effect of maintaining the inhibitory effect against gastric acid secretion, thereby maintaining intragastric pH high for a long time, and having more safety and appropriate physicochemical stability. Provided is a compound represented by where R1 and R3 may be the same or different and each represent a hydrogen atom or a C1-C6 alkyl group; R2 represents (5,5-dimethyl-1,3-dioxan-2-yl)methoxy group, 5,7-dioxaspiro[2.5]oct-6-ylmethoxy group, 1,5,9-trioxaspiro[5.5]undec-3-ylmethoxy group, or (2,2-dimethyl-1,3-dioxan-5-yl)methoxy group; R4, R5, R6 and R7 represent a hydrogen atom, halogen atom, C1-C6 alkyl group, C1-C6 haloalkyl group, C1-C6 alkoxy group or C1-C6 haloalkoxy group; and W1 represents a single bond, methylene or ethylene group, a salt thereof or a solvate of these.

    摘要翻译： 提供了可用作酸性相关疾病的治疗或预防剂的新型化合物，其对胃酸分泌具有优异的抑制作用，保持对胃酸分泌的抑制作用的优异效果，从而保持胃内pH高 长时间，具有更多的安全性和适当的物理化学稳定性。 提供一种化合物，其中R 1和R 3可以相同或不同，各自表示氢原子或C 1 -C 6烷基; R2代表（5,5-二甲基-1,3-二恶烷-2-基）甲氧基，5,7-二氧杂螺[2.5]辛-6-基甲氧基，1,5,9-三氧杂螺[5.5]十一烷-3 - 甲氧基或（2,2-二甲基-1,3-二恶烷-5-基）甲氧基; R4，R5，R6和R7表示氢原子，卤素原子，C1-C6烷基，C1-C6卤代烷基，C1-C6烷氧基或C1-C6卤代烷氧基; W1表示单键，亚甲基或亚乙基，它们的盐或它们的溶剂合物。

    Benzimidazole compound
    2.
    发明授权
    Benzimidazole compound 有权
    苯并咪唑化合物

    公开(公告)号：US08124780B2

    公开(公告)日：2012-02-28

    申请号：US12189590

    申请日：2008-08-11

    申请人： Shuhei Miyazawa ,  Masanobu Shinoda ,  Tetsuya Kawahara ,  Nobuhisa Watanabe ,  Hitoshi Harada ,  Daisuke Iida ,  Hiroki Terauchi ,  Junichi Nagakawa ,  Hideaki Fujisaki ,  Atsuhiko Kubota ,  Masato Ueda

    发明人： Shuhei Miyazawa ,  Masanobu Shinoda ,  Tetsuya Kawahara ,  Nobuhisa Watanabe ,  Hitoshi Harada ,  Daisuke Iida ,  Hiroki Terauchi ,  Junichi Nagakawa ,  Hideaki Fujisaki ,  Atsuhiko Kubota ,  Masato Ueda

    IPC分类号： C07D401/12

    CPC分类号： C07D491/04 ,  C07D405/14 ,  C07D493/08 ,  C07D493/10

    摘要： A novel chemical compound useful as a therapeutic or prophylactic agent for acid-related diseases is provided, which has an excellent inhibitory effect against gastric acid secretion, an excellent effect of maintaining the inhibitory effect against gastric acid secretion, thereby maintaining intragastric pH high for a long time, and having more safety and appropriate physicochemical stability. Provided is a compound represented by where R1 and R3 may be the same or different and each represent a hydrogen atom or a C1-C6 alkyl group; R2 represents (5,5-dimethyl-1,3-dioxan-2-yl)methoxy group, 5,7-dioxaspiro[2.5]oct-6-ylmethoxy group, 1,5,9-trioxaspiro[5.5]undec-3-ylmethoxy group, or (2,2-dimethyl-1,3-dioxan-5-yl)methoxy group; R4, R5, R6 and R7 represent a hydrogen atom, halogen atom, C1-C6 alkyl group, C1-C6 haloalkyl group, C1-C6 alkoxy group or C1-C6 haloalkoxy group; and W1 represents a single bond, methylene or ethylene group, a salt thereof or a solvate of these.

    摘要翻译： 提供了可用作酸性相关疾病的治疗或预防剂的新型化合物，其对胃酸分泌具有优异的抑制作用，保持对胃酸分泌的抑制作用的优异效果，从而保持胃内pH高 长时间，具有更多的安全性和适当的物理化学稳定性。 提供一种化合物，其中R 1和R 3可以相同或不同，各自表示氢原子或C 1 -C 6烷基; R2代表（5,5-二甲基-1,3-二恶烷-2-基）甲氧基，5,7-二氧杂螺[2.5]辛-6-基甲氧基，1,5,9-三氧杂螺[5.5]十一烷-3 - 甲氧基或（2,2-二甲基-1,3-二恶烷-5-基）甲氧基; R4，R5，R6和R7表示氢原子，卤素原子，C1-C6烷基，C1-C6卤代烷基，C1-C6烷氧基或C1-C6卤代烷氧基; W1表示单键，亚甲基或亚乙基，它们的盐或它们的溶剂合物。

    Benzimidazole compound
    3.
    发明授权
    Benzimidazole compound 有权
    苯并咪唑化合物

    公开(公告)号：US07425634B2

    公开(公告)日：2008-09-16

    申请号：US11520838

    申请日：2006-09-14

    申请人： Shuhei Miyazawa ,  Masanobu Shinoda ,  Tetsuya Kawahara ,  Nobuhisa Watanabe ,  Hitoshi Harada ,  Daisuke Iida ,  Hiroki Terauchi ,  Junichi Nagakawa ,  Hideaki Fujisaki ,  Atsuhiko Kubota ,  Masato Ueda

    发明人： Shuhei Miyazawa ,  Masanobu Shinoda ,  Tetsuya Kawahara ,  Nobuhisa Watanabe ,  Hitoshi Harada ,  Daisuke Iida ,  Hiroki Terauchi ,  Junichi Nagakawa ,  Hideaki Fujisaki ,  Atsuhiko Kubota ,  Masato Ueda

    IPC分类号： C07D401/12

    CPC分类号： C07D491/04 ,  C07D405/14 ,  C07D493/08 ,  C07D493/10

    摘要： An object of the present invention is to provide a novel chemical compound useful as a therapeutic or prophylactic agent for acid-related diseases, having an excellent inhibitory effect against gastric acid secretion, an excellent effect of maintaining the inhibitory effect against gastric acid secretion, thereby maintaining intragastric pH high for a long time, and having more safety and appropriate physicochemical stability.Provided is a compound represented by where R1 and R3 may be the same or different and each represent a hydrogen atom or a C1-C6 alkyl group; R2 represents (5,5-dimethyl-1,3-dioxan-2-yl)methoxy group, 5,7-dioxaspiro[2.5]oct-6-ylmethoxy group, 1,5,9-trioxaspiro[5.5]undec-3-ylmethoxy group, or (2,2-dimethyl-1,3-dioxan-5-yl)methoxy group; R4, R5, R6 and R7 represent a hydrogen atom, halogen atom, C1-C6 alkyl group, C1-C6 haloalkyl group, C1-C6 alkoxy group or C1-C6 haloalkoxy group; and W1 represents a single bond, methylene or ethylene group, a salt thereof or a solvate of these.

    摘要翻译： 本发明的目的是提供一种新颖的化合物，其可用作酸性相关疾病的治疗或预防剂，对胃酸分泌具有优异的抑制作用，具有保持对胃酸分泌的抑制作用的优异效果，从而 长时间保持胃内pH高，并具有更多的安全性和适当的物理化学稳定性。 其中R 1和R 3可以相同或不同，表示氢原子或C1-C6烷基; R 5表示（5,5-二甲基-1,3-二恶烷-2-基）甲氧基，5,7-二氧杂螺[2.5]辛-6-基甲氧基，1,5,9 - 三氧杂螺[5.5]十一烷-3-基甲氧基或（2,2-二甲基-1,3-二恶烷-5-基）甲氧基; R 4，R 5，R 6和R 7表示氢原子，卤素原子，C 1 -C 6 烷基，C1-C6卤代烷基，C1-C6烷氧基或C1-C6卤代烷氧基; 和W 1表示单键，亚甲基或亚乙基，其盐或它们的溶剂合物。

    Benzimidazole compound
    5.
    发明申请
    Benzimidazole compound 有权
    苯并咪唑化合物

    公开(公告)号：US20070010542A1

    公开(公告)日：2007-01-11

    申请号：US11520838

    申请日：2006-09-14

    申请人： Shuhei Miyazawa ,  Masanobu Shinoda ,  Tetsuya Kawahara ,  Nobuhisa Watanabe ,  Hitoshi Harada ,  Daisuke Iida ,  Hiroki Terauchi ,  Junichi Nagakawa ,  Hideaki Fujisaki ,  Atsuhiko Kubota ,  Masato Ueda

    发明人： Shuhei Miyazawa ,  Masanobu Shinoda ,  Tetsuya Kawahara ,  Nobuhisa Watanabe ,  Hitoshi Harada ,  Daisuke Iida ,  Hiroki Terauchi ,  Junichi Nagakawa ,  Hideaki Fujisaki ,  Atsuhiko Kubota ,  Masato Ueda

    IPC分类号： A61K31/4747 ,  A61K31/4439 ,  C07D405/14

    CPC分类号： C07D491/04 ,  C07D405/14 ,  C07D493/08 ,  C07D493/10

    摘要： An object of the present invention is to provide a novel chemical compound useful as a therapeutic or prophylactic agent for acid-related diseases, having an excellent inhibitory effect against gastric acid secretion, an excellent effect of maintaining the inhibitory effect against gastric acid secretion, thereby maintaining intragastric pH high for a long time, and having more safety and appropriate physicochemical stability. Provided is a compound represented by where R1 and R3 may be the same or different and each represent a hydrogen atom or a C1-C6 alkyl group; R2 represents (5,5-dimethyl-1,3-dioxan-2-yl)methoxy group, 5,7-dioxaspiro[2.5]oct-6-ylmethoxy group, 1,5,9-trioxaspiro[5.5]undec-3-ylmethoxy group, or (2,2-dimethyl-1,3-dioxan-5-yl)methoxy group; R4, R5, R6 and R7 represent a hydrogen atom, halogen atom, C1-C6 alkyl group, C1-C6 haloalkyl group, C1-C6 alkoxy group or C1-C6 haloalkoxy group; and W1 represents a single bond, methylene or ethylene group, a salt thereof or a solvate of these.

    摘要翻译： 本发明的目的是提供一种新颖的化合物，其可用作酸性相关疾病的治疗或预防剂，对胃酸分泌具有优异的抑制作用，具有保持对胃酸分泌的抑制作用的优异效果，从而 长时间保持胃内pH高，并具有更多的安全性和适当的物理化学稳定性。 其中R 1和R 3可以相同或不同，表示氢原子或C1-C6烷基; R 5表示（5,5-二甲基-1,3-二恶烷-2-基）甲氧基，5,7-二氧杂螺[2.5]辛-6-基甲氧基，1,5,9 - 三氧杂螺[5.5]十一烷-3-基甲氧基或（2,2-二甲基-1,3-二恶烷-5-基）甲氧基; R 4，R 5，R 6和R 7表示氢原子，卤素原子，C 1 -C 6 烷基，C1-C6卤代烷基，C1-C6烷氧基或C1-C6卤代烷氧基; 和W 1表示单键，亚甲基或亚乙基，其盐或它们的溶剂合物。

    PROCESS FOR PRODUCTION OF SULFINYLBENZIMIDAZOLE COMPOUNDS OR SALTS THEREOF
    7.
    发明申请
    PROCESS FOR PRODUCTION OF SULFINYLBENZIMIDAZOLE COMPOUNDS OR SALTS THEREOF 审中-公开
    生产磺酰苯并咪唑化合物或其盐的方法

    公开(公告)号：US20100022778A1

    公开(公告)日：2010-01-28

    申请号：US12441075

    申请日：2007-10-11

    申请人： Atsushi Kamada ,  Daisuke Iida ,  Hiroki Terauchi

    发明人： Atsushi Kamada ,  Daisuke Iida ,  Hiroki Terauchi

    IPC分类号： C07D405/14

    CPC分类号： C07D405/14

    摘要： It is an object of the present invention to provide a process for the production on an industrial scale of a compound (1) or a salt thereof. There is provided a process for the production of compound (1) represented by the formula or a salt thereof: (wherein R1 and R3 independently represents a hydrogen atom or a methyl group), the process comprising the steps of: (a) reacting together a compound (3T) represented by the formula: (wherein X1 represents a leaving group, and R1 and R3 are defined as above) and (2,2-dimethyl-1,3-dioxan-5-yl)methanol represented by the formula or a salt thereof: so as to produce a compound (2T) represented by the formula (wherein R1 and R3 are defined as above); and (b) reacting the compound represented by above formula (2T) with an oxidizing agent.

    摘要翻译： 本发明的目的是提供一种在工业规模上生产化合物（1）或其盐的方法。 提供一种制备由下式表示的化合物（1）或其盐：（其中R 1和R 3独立地表示氢原子或甲基）的方法，该方法包括以下步骤：（a）使 由式（其中X1表示离去基团，R1和R3如上所定义）的化合物（3T）和由式（3）表示的（2,2-二甲基-1,3-二恶烷-5-基）甲醇 或其盐：以制备由式（其中R 1和R 3如上定义）表示的化合物（2T）; 和（b）使由上式（2T）表示的化合物与氧化剂反应。

    Image reading device and image forming apparatus having selectively switchable reference surfaces
    8.
    发明授权
    Image reading device and image forming apparatus having selectively switchable reference surfaces 有权

    公开(公告)号：US10721365B2

    公开(公告)日：2020-07-21

    申请号：US16253177

    申请日：2019-01-21

    申请人： Hiroki Terauchi

    发明人： Hiroki Terauchi

    IPC分类号： H04N1/60 ,  H04N1/00 ,  G03G15/22

    摘要： An image reading device includes a reader, an opposing member, and circuitry. The reader is configured to read an image of an object to be conveyed. The opposing member has a plurality of opposing portions that include reference surfaces selectively switchable to be placed at a reading position of the reader. The reference surfaces include two or more identical reference surfaces. The circuitry is configured to determine whether an evaluation reading value of reading values read by the reader on each of the two or more identical reference surfaces is within a prescribed range and perform correction operation of the image reading device with the evaluation reading value within the prescribed range out of the reading values of the two or more identical reference surfaces.

    IMAGE FORMING APPARATUS
    9.
    发明公开
    IMAGE FORMING APPARATUS 审中-公开

    公开(公告)号：US20240027941A1

    公开(公告)日：2024-01-25

    申请号：US18332195

    申请日：2023-06-09

    申请人： Hiroki Terauchi ,  Takahiro Konishi

    发明人： Hiroki Terauchi ,  Takahiro Konishi

    IPC分类号： G03G15/16

    CPC分类号： G03G15/1615

    摘要： An image forming apparatus includes an intermediate transfer unit, a secondary transfer unit, and a positioner. The intermediate transfer unit includes an intermediate transferor to bear an image. The secondary transfer unit includes a secondary transfer member to transfer the image borne by the intermediate transferor to a medium. The positioner positions the secondary transfer unit with respect to the intermediate transfer unit. The positioner includes a first member and a second member. The first member is disposed in the intermediate transfer unit. The second member is attachable to and detachable from the secondary transfer unit.

    Anti-leishmania agent
    10.
    发明申请
    Anti-leishmania agent 审中-公开
    抗利什曼药剂

    公开(公告)号：US20060252800A1

    公开(公告)日：2006-11-09

    申请号：US10555539

    申请日：2004-04-30

    申请人： Masataka Ihara ,  Kiyosei Takasu ,  Hiroki Terauchi ,  Setsuko Sekita ,  Marii Takahashi

    发明人： Masataka Ihara ,  Kiyosei Takasu ,  Hiroki Terauchi ,  Setsuko Sekita ,  Marii Takahashi

    IPC分类号： A61K31/4439 ,  C07D417/14

    CPC分类号： C07D417/14

    摘要： The present invention is to provide a new anti-leishmania agent with fewer side effects, having a high cell proliferation-inhibiting effect to leishamia protozoa, and also easy to manufacture at a low cost. A compound wherein a heterocycle with a conjugated system and a nitrogen atom and a heterocycle with a nitrogen atom and a sulfur atom are bound by a carbon chain with an ethylene group, that is a compound wherein a specific 5- to 8-membered heterocyclic ring and a specific 5- to 8-membered heterocycle having a conjugated system are bound via a vinylene group, more particularly a specific rhodacyanine dye compound is used as an active ingredient of the anti-leishmania agent.

    摘要翻译： 本发明提供一种具有较少副作用的新型利什曼原虫药，其具有对嗜酸性原虫的高细胞增殖抑制作用，并且也易于以低成本制造。 其中具有共轭体系和氮原子的杂环和具有氮原子和硫原子的杂环的亚乙基与碳原子键合的化合物，其中特定的5-至8-元杂环 并且具有共轭体系的具体的5-至8-元杂环通过亚乙烯基结合，更具体地，使用特定的罗丹参素染料化合物作为抗利什曼原虫剂的活性成分。