发明授权
US08133694B2 Functional vitamin D derivatives and method of determining 25-hydroxy- and 1α, 25-dihydroxy vitamin D
有权
功能性维生素D衍生物和测定25-羟基和1α，25-二羟基维生素D的方法
- 专利标题： Functional vitamin D derivatives and method of determining 25-hydroxy- and 1α, 25-dihydroxy vitamin D
- 专利标题（中）： 功能性维生素D衍生物和测定25-羟基和1α，25-二羟基维生素D的方法
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申请号： US10790746申请日： 2004-03-03
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公开(公告)号： US08133694B2公开(公告)日： 2012-03-13
- 发明人: Franz Paul Armbruster , Wolfgang Voelter , Jens Tampe , Christian Birkmayer
- 申请人： Franz Paul Armbruster , Wolfgang Voelter , Jens Tampe , Christian Birkmayer
- 申请人地址： DE Bensheim AT Vienna
- 专利权人： Immundiagnostik AG,Biomedica GmbH
- 当前专利权人： Immundiagnostik AG,Biomedica GmbH
- 当前专利权人地址： DE Bensheim AT Vienna
- 代理机构： Birch, Stewart, Kolasch & Birch, LLP
- 优先权： DE19828379 19980625; DE19840435 19980904
- 主分类号： G01N33/53
- IPC分类号： G01N33/53 ; G01N33/532 ; C07K16/00 ; C07K1/14
摘要：
The preparation of vitamin D compounds of formula (I) with a label attached to a spacer group in the 3 position is disclosed. In the above formula (I), O represents the oxygen atom of an ether group; Y represents hydrogen or hydroxy; A represents a label such as biotin, digoxigenin, or another vitamin D group; R represents a substituted hydrocarbon side-group of vitamin D or a vitamin D metabolite. Also disclosed is a method of measuring 25-hydroxy vitamin D metabolite and a 1α,25-dihydroxy vitamin D metabolite in a sample.