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1.发明授权Functional vitamin D derivatives and method of determining 25-hydroxy- and 1α, 25-dihydroxy vitamin D 有权功能性维生素D衍生物和测定25-羟基和1α，25-二羟基维生素D的方法公开(公告)号：US08133694B2
公开(公告)日：2012-03-13
申请号：US10790746
申请日：2004-03-03
IPC分类号： G01N33/53 , G01N33/532 , C07K16/00 , C07K1/14
CPC分类号： G01N33/82 , Y10T436/13
摘要： The preparation of vitamin D compounds of formula (I) with a label attached to a spacer group in the 3 position is disclosed. In the above formula (I), O represents the oxygen atom of an ether group; Y represents hydrogen or hydroxy; A represents a label such as biotin, digoxigenin, or another vitamin D group; R represents a substituted hydrocarbon side-group of vitamin D or a vitamin D metabolite. Also disclosed is a method of measuring 25-hydroxy vitamin D metabolite and a 1α,25-dihydroxy vitamin D metabolite in a sample.
摘要翻译： 公开了具有连接到3位上的间隔基的标记的式（I）的维生素D化合物的制备。 在上述式（I）中，O表示醚基的氧原子; Y表示氢或羟基; A代表生物素，地高辛或其他维生素D组的标签; R表示维生素D或维生素D代谢物的取代烃侧基。 还公开了一种在样品中测量25-羟基维生素D代谢物和1α，25-二羟基维生素D代谢物的方法。
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2.发明授权Functional vitamin D derivatives and a method for determining 25-hydroxy-vitamin D and 1&agr;, dihydroxy-vitamin D 有权功能性维生素D衍生物和一种测定25-羟基维生素D和1α二羟基维生素D的方法公开(公告)号：US06787660B1
公开(公告)日：2004-09-07
申请号：US09720338
申请日：2001-02-20
IPC分类号： C07J40100
CPC分类号： G01N33/82
摘要： Vitamin D compounds of formula (I) with a label attached to a spacer group in the 3 position are disclosed. In the above formula (I), X is an optionally substituted hydrocarbon group with a length of 0.8-4.2 nm, optionally containing the heteroatoms S, O, N or P; Y is H or OH; A is a label capable of binding with high affinity to a protein; R is an optionally substituted hydrocarbon side chain of a D vitamin or a D vitamin metabolite. Also disclosed is the preparation of formula (I).
摘要翻译： 公开了具有连接到3位上的间隔基的标记的式（I）的维生素D化合物。在上式（I）中，X是任选取代的烃基，其长度为0.8-4.2nm，任选地含有 杂原子S，O，N或P; Y是H或OH; A是能够以高亲和力结合蛋白质的标签; R是D维生素或D维生素代谢物的任选取代的烃侧链。 还公开了式（I）的制备。
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3.发明申请Functional vitamin D derivatives and method of determining 25-hydroxy- and 1alpha, 25-dihydroxy vitamin D 有权功能性维生素D衍生物和测定25-羟基和1α，25-二羟维生素D的方法公开(公告)号：US20050014211A1
公开(公告)日：2005-01-20
申请号：US10790746
申请日：2004-03-03
IPC分类号： G01N33/82 , G01N33/53 , C07C401/00 , G01N33/537 , G01N33/543
CPC分类号： G01N33/82 , Y10T436/13
摘要： The preparation of vitamin D compounds of formula (I) with a label attached to a spacer group in the 3 position is disclosed. In the above formula (I), O represents the oxygen atom of an ether group; Y represents hydrogen or hydroxy; A represents a label such as biotin, digoxigenin, or another vitamin D group; R represents a substitured hydrocarbon side-group of vitamin D or a vitamin D metabolite. Also disclosed is a method of measuring 25-hydroxy vitamin D metabolite and a 1α,25-dihydroxy vitamin D metabolite in a sample.
摘要翻译： 公开了具有连接到3位上的间隔基的标记的式（I）的维生素D化合物的制备。 在上述式（I）中，O表示醚基的氧原子; Y表示氢或羟基; A代表生物素，地高辛或其他维生素D组的标签; R代表维生素D或维生素D代谢物的替代碳氢化合物侧基。 还公开了一种在样品中测量25-羟基维生素D代谢物和1α，25-二羟基维生素D代谢物的方法。
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公开(公告)号：US4624804A
公开(公告)日：1986-11-25
申请号：US536760
申请日：1983-09-28
申请人： Wolfgang Voelter , Theodor Lippert
发明人： Wolfgang Voelter , Theodor Lippert
摘要： The disclosure relates to a process of preparing relaxin from aqueous, decaseined milk or milk concentrate. Proteins are precipitated and separated, and a relaxin-containing precipitate is produced subsequently. The relaxin-containing precipitate is then purified in the customary manner. There is also disclosed a pharmaceutically active product containing such relaxin.
摘要翻译： 本公开涉及从水性，脱脂乳或乳浓缩物中制备松弛素的方法。 沉淀和分离蛋白质，随后产生含松弛素的沉淀物。 然后以常规方式纯化含有松弛素的沉淀物。 还公开了含有这种松弛素的药物活性产物。
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公开(公告)号：US4440692A
公开(公告)日：1984-04-03
申请号：US372798
申请日：1982-04-28
申请人： Hubert Kalbacher , Wolfgang Voelter
发明人： Hubert Kalbacher , Wolfgang Voelter
IPC分类号： C07C69/96 , C07C67/00 , C07C201/00 , C07C205/41 , C07C231/00 , C07C239/00 , C07C241/00 , C07C247/00 , C07C251/62 , C07C269/04 , C07C271/08 , C07C271/10 , C07C271/22 , C07D207/12 , C07D209/20 , C07K1/06 , C07K5/06 , C07K5/078 , C07K5/10 , C07K5/103 , C07K7/06 , C07K14/655 , C07C125/063
CPC分类号： C07K5/06156 , C07D209/20 , C07K1/063 , C07K1/064 , C07K1/068 , C07K14/655 , C07K5/1013
摘要： Substituted carbonic acid esters and urethanes having the formula ##STR1## wherein Ad is a substituted or unsubstituted 1-adamantyl residue, R.sup.1 and R.sup.2 are saturated alkyl groups and X is chlorine, fluorine, azido or unsubstituted or substituted phenoxy. These compounds can be used in the synthesis of various peptides.
摘要翻译： 具有式“IMAGE”的取代的碳酸酯和氨基甲酸酯其中Ad是取代或未取代的1-金刚烷基残基，R1和R2是饱和烷基，X是氯，氟，叠氮基或未取代或取代的苯氧基。 这些化合物可用于各种肽的合成。
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公开(公告)号：US06927207B1
公开(公告)日：2005-08-09
申请号：US09601667
申请日：1999-02-03
申请人： Peter Morris , Thomas Stiefel , Wolfgang Voelter , Peter Welters
发明人： Peter Morris , Thomas Stiefel , Wolfgang Voelter , Peter Welters
CPC分类号： C12N15/8242 , A61K38/00 , A61K48/00 , C07K14/42
摘要： The present invention relates to isolated mistletoe lectin polypeptides and the pharmaceutical composition comprising the polypeptides thereof. Also, the present invention relates to processes for the production of mistletoe lectin polypeptides in homologous and heterologous host systems and mistletoe lectin peptides. Further, nucleic acid molecules are provided, which encode these mistletoe lectin polypeptides, and also pharmaceutical compositions comprising mistletoe lectin nucleic acids.
摘要翻译： 本发明涉及分离的槲寄生凝集素多肽和包含其多肽的药物组合物。 此外，本发明涉及在同源和异源宿主系统和槲寄生凝集素肽中产生槲寄生凝集素多肽的方法。 此外，提供编码这些槲寄生凝集素多肽的核酸分子，以及包含槲寄生凝集素核酸的药物组合物。
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公开(公告)号：US20050142183A1
公开(公告)日：2005-06-30
申请号：US11042707
申请日：2005-01-25
申请人： Peter Morris , Thomas Stiefel , Wolfgang Voelter , Peter Welters
发明人： Peter Morris , Thomas Stiefel , Wolfgang Voelter , Peter Welters
IPC分类号： A61K38/00 , A61K48/00 , C07K14/42 , C12N15/82 , A61K38/16 , A01H1/00 , A61K9/127 , C07H21/04 , C12N5/04 , C12Q1/68
CPC分类号： C12N15/8242 , A61K38/00 , A61K48/00 , C07K14/42
摘要： The present invention relates to processes for the production of mistletoe lectin polypeptides in homologous and heterologous host systems and mistletoe lectin peptides as such. Further, nucleic acid molecules are provided, which code for these mistletoe lectin polypeptides, and also pharmaceutical compositions which contain these mistletoe lectin polypeptides or mistletoe lectin nucleic acids. In order to produce the many mistletoe lectin isoenzymes contained in the natural mistletoe extract, which can trigger anti-tumorigenic and mood-brightening effects, in sufficient quantities, the present invention provides a process which makes it possible to produce mistletoe lectins in required quantities biotechnologically and at the same time to recreate the diversity of the natural mistletoe extract in mistletoe lectin isoenzymes.
摘要翻译： 本发明涉及在同源和异源宿主系统中生产槲寄生凝集素多肽的方法以及槲寄生凝集素肽。 此外，提供编码这些槲寄生凝集素多肽的核酸分子，以及含有这些槲寄生凝集素多肽或槲寄生凝集素核酸的药物组合物。 为了产生足够量的可以引发抗致瘤性和情绪增白作用的天然槲寄生提取物中含有的许多槲寄生凝集素同工酶，本发明提供了一种能够生产生物技术所需量的槲寄生凝集素的方法 同时在槲寄生凝集素同工酶中重现天然槲寄生提取物的多样性。
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公开(公告)号：US07265217B2
公开(公告)日：2007-09-04
申请号：US11042707
申请日：2005-01-25
申请人： Peter Morris , Thomas Stiefel , Wolfgang Voelter , Peter Welters
发明人： Peter Morris , Thomas Stiefel , Wolfgang Voelter , Peter Welters
CPC分类号： C12N15/8242 , A61K38/00 , A61K48/00 , C07K14/42
摘要： The present invention relates to processes for the production of mistletoe lectin polypeptides in homologous and heterologous host systems and mistletoe lectin peptides. Further, nucleic acid molecules are provided, which encode these mistletoe lectin polypeptides, and also pharmaceutical compositions comprising mistletoe lectin nucleic acids. The present invention also relates to isolated mistletoe lectin polypeptides and pharmaceutical compositions comprising said polypeptides.
摘要翻译： 本发明涉及在同源和异源宿主系统和槲寄生凝集素肽中产生槲寄生凝集素多肽的方法。 此外，提供编码这些槲寄生凝集素多肽的核酸分子，以及包含槲寄生凝集素核酸的药物组合物。 本发明还涉及分离的槲寄生凝集素多肽和包含所述多肽的药物组合物。
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公开(公告)号：US4937352A
公开(公告)日：1990-06-26
申请号：US246049
申请日：1988-09-16
申请人： Wolfgang Voelter
发明人： Wolfgang Voelter
IPC分类号： C12P21/02 , A61K38/22 , C07D233/54 , C07D233/56 , C07D233/58 , C07D233/64 , C07D487/04 , C07K5/04 , C07K5/078 , C07K5/097
CPC分类号： C07D233/64 , C07D487/04 , C07K5/06173 , C07K5/0825
摘要： A process is disclosed for the preparation of new N.sup..tau. -substituted histidine derivatives of the general formula ##STR1## According to the process, a histidine derivative of the general formula ##STR2## is reacted with phosgene, and the resultant product is then alkylated and thereafter hydrolyzed with an acid.The products obtained by the process are highly useful for prepration of histidine-analogous proteins and enzymes.
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公开(公告)号：US4772721A
公开(公告)日：1988-09-20
申请号：US622595
申请日：1984-06-20
申请人： Wolfgang Voelter
发明人： Wolfgang Voelter
IPC分类号： C12P21/02 , A61K38/22 , C07D233/54 , C07D233/56 , C07D233/58 , C07D233/64 , C07D487/04 , C07K5/04 , C07K5/078 , C07K5/097
CPC分类号： C07D233/64 , C07D487/04 , C07K5/06173 , C07K5/0825
摘要： A process is disclosed for the preparation of new N.sup..tau. -substituted histidine derivatives of the general formula ##STR1## According to the process, a histidine derivative of the general formula ##STR2## is reacted with phosgene, and the resultant product is then alkylated and thereafter hydrolyzed with an acid.The products obtained by the process are highly useful for preparation of histidine-analogous proteins and enzymes.
摘要翻译： 公开了用于制备通式为（1）的新的N tau-取代的组氨酸衍生物的方法（1）根据该方法，将通式（IMAGE）（2）的组氨酸衍生物与光气反应， 然后将所得产物烷基化，然后用酸水解。 通过该方法获得的产物对组氨酸类似蛋白质和酶的制备非常有用。
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