发明授权
US08138189B2 Substituted benzene compounds as modulators of the glucocorticoid receptor
失效
取代苯化合物作为糖皮质激素受体的调节剂
- 专利标题： Substituted benzene compounds as modulators of the glucocorticoid receptor
- 专利标题（中）： 取代苯化合物作为糖皮质激素受体的调节剂
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申请号： US12727269申请日： 2010-03-19
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公开(公告)号： US08138189B2公开(公告)日： 2012-03-20
- 发明人: Daniel Hunziker , Chrisitan Lerner , Werner Mueller , Ulrike Obst Sander , Philippe Pflieger , Pius Waldmeier
- 申请人： Daniel Hunziker , Chrisitan Lerner , Werner Mueller , Ulrike Obst Sander , Philippe Pflieger , Pius Waldmeier
- 申请人地址： US NJ Nutley
- 专利权人： Hoffman-La Roche Inc.
- 当前专利权人： Hoffman-La Roche Inc.
- 当前专利权人地址： US NJ Nutley
- 代理商 George W. Johnston; Patricia S. Rocha-Tramaloni; Gene J. Yao
- 优先权： EP09156260 20090326
- 主分类号： A61K31/497
- IPC分类号： A61K31/497
摘要：
The present invention relates to compounds of formula I wherein R.sup.1a to R.sup.1e and R.sup.2 to R.sup.5 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are glucocorticoid receptor antagonists useful for the treatment and/or prevention of diseases such as diabetes, dyslipidemia, obesity, hypertension, cardiovascular diseases, adrenal imbalance or depression.
公开/授权文献
- US20100249139A1 1,1,1-TRIFLUORO-2-HYDROXYPROPYL COMPOUNDS 公开/授权日：2010-09-30
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