发明授权
- 专利标题： Inhibitors of protein kinases
- 专利标题（中）： 蛋白激酶抑制剂
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申请号： US12386509申请日： 2009-04-16
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公开(公告)号： US08138339B2公开(公告)日： 2012-03-20
- 发明人: Shawn M. Bauer , Zhaozhong J. Jia , Yonghong Song , Qing Xu , Mukund Mehrotra , Jack W. Rose , Wolin Huang , Chandrasekar Venkataramani , Anjali Pandey
- 申请人： Shawn M. Bauer , Zhaozhong J. Jia , Yonghong Song , Qing Xu , Mukund Mehrotra , Jack W. Rose , Wolin Huang , Chandrasekar Venkataramani , Anjali Pandey
- 申请人地址： US CA South San Francisco
- 专利权人： Portola Pharmaceuticals, Inc.
- 当前专利权人： Portola Pharmaceuticals, Inc.
- 当前专利权人地址： US CA South San Francisco
- 代理机构： Kilpatrick Townsend Stockton LLP
- 主分类号： C07D239/28
- IPC分类号： C07D239/28 ; C07D403/02 ; C07D413/02 ; C07D279/12 ; A61K31/506 ; A61K31/501 ; A61K31/5377 ; A61K31/551 ; A61K31/541
摘要：
The present invention is directed to 2-cycloalkylamino-4-arylamino-benzamide compounds of formula I pharmaceutically acceptable salts thereof which are inhibitors of syk and/or JAK kinase. The present invention is also directed to intermediates used in making such compounds, the preparation of such a compound, pharmaceutical compositions containing such a compound, methods of inhibition syk and/or JAK kinase activity, and methods to prevent or treat a number of conditions mediated at least in part by syk and/or JAK kinase activity, such as cardiovascular disease, inflammatory disease, autoimmune disease and cell proliferative disorder.
公开/授权文献
- US20090318407A1 Inhibitors of protein kinases 公开/授权日：2009-12-24
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