发明授权
- 专利标题： DNA damage repair inhibitors for treatment of cancer
- 专利标题（中）： DNA损伤修复抑制剂治疗癌症
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申请号： US11245735申请日： 2005-10-06
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公开(公告)号： US08143241B2公开(公告)日： 2012-03-27
- 发明人: Alan Ashworth , Stephen Jackson , Niall Martin , Graeme Smith , Mark O'Connor
- 申请人： Alan Ashworth , Stephen Jackson , Niall Martin , Graeme Smith , Mark O'Connor
- 申请人地址： GB Cambridge GB London
- 专利权人： Kudos Pharmaceuticals Limited,The Institute of Cancer Research
- 当前专利权人： Kudos Pharmaceuticals Limited,The Institute of Cancer Research
- 当前专利权人地址： GB Cambridge GB London
- 代理机构： Bozicevic, Field & Francis LLP
- 代理商 Pamela J. Sherwood
- 主分类号： A61K31/50
- IPC分类号： A61K31/50 ; A61K31/44 ; A61K31/415 ; A01N43/00
摘要：
The present invention relates to the recognition that inhibition of the base excision repair pathway is selectively lethal in cells which are deficient in HR dependent DNA DSB repair. Methods and means relating to the treatment of cancers which are deficient in HR dependent DNA DSB repair using inhibitors which target base excision repair components, such as PARP, is provided herein.
公开/授权文献
- US20060142231A1 DNA damage repair inhibitors for treatment of cancer 公开/授权日：2006-06-29
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