Invention Grant
- Patent Title: DNA damage repair inhibitors for treatment of cancer
- Patent Title (中): DNA损伤修复抑制剂治疗癌症
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Application No.: US11245735Application Date: 2005-10-06
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Publication No.: US08143241B2Publication Date: 2012-03-27
- Inventor: Alan Ashworth , Stephen Jackson , Niall Martin , Graeme Smith , Mark O'Connor
- Applicant: Alan Ashworth , Stephen Jackson , Niall Martin , Graeme Smith , Mark O'Connor
- Applicant Address: GB Cambridge GB London
- Assignee: Kudos Pharmaceuticals Limited,The Institute of Cancer Research
- Current Assignee: Kudos Pharmaceuticals Limited,The Institute of Cancer Research
- Current Assignee Address: GB Cambridge GB London
- Agency: Bozicevic, Field & Francis LLP
- Agent Pamela J. Sherwood
- Main IPC: A61K31/50
- IPC: A61K31/50 ; A61K31/44 ; A61K31/415 ; A01N43/00
Abstract:
The present invention relates to the recognition that inhibition of the base excision repair pathway is selectively lethal in cells which are deficient in HR dependent DNA DSB repair. Methods and means relating to the treatment of cancers which are deficient in HR dependent DNA DSB repair using inhibitors which target base excision repair components, such as PARP, is provided herein.
Public/Granted literature
- US20060142231A1 DNA damage repair inhibitors for treatment of cancer Public/Granted day:2006-06-29
Information query
