-
公开(公告)号:US20060142231A1
公开(公告)日:2006-06-29
申请号:US11245735
申请日:2005-10-06
申请人: Alan Ashworth , Stephen Jackson , Niall Martin , Graeme Smith , Mark O'Connor
发明人: Alan Ashworth , Stephen Jackson , Niall Martin , Graeme Smith , Mark O'Connor
IPC分类号: A61K48/00 , A61K31/522 , A61K31/502 , A61K31/473 , A61K31/517 , A61K31/4704 , A61K31/4035 , A61K31/366
CPC分类号: A61K31/366 , A61K31/405 , A61K31/4184 , A61K31/4706 , A61K31/473 , A61K31/502 , A61K31/517 , A61K31/522 , A61K31/675 , Y02A50/473
摘要: DNA Damage Repair Inhibitors for Treatment of Cancer The present invention relates to the recognition that inhibition of the base excision repair pathway is selectively lethal in cells which are deficient in HR dependent DNA DSB repair. Methods and means relating to the treatment of cancers which are deficient in HR dependent DNA DSB repair using inhibitors which target base excision repair components, such as PARP, is provided herein.
摘要翻译: 用于治疗癌症的DNA损伤修复抑制剂本发明涉及对在HR依赖性DNA DSB修复缺陷的细胞中碱基切除修复途径的抑制选择性致死的认识。 本文提供了使用靶向基础切除修复组分(如PARP)的抑制剂治疗缺乏HR依赖性DNA DSB修复的癌症治疗方法和手段。
-
公开(公告)号:US08143241B2
公开(公告)日:2012-03-27
申请号:US11245735
申请日:2005-10-06
申请人: Alan Ashworth , Stephen Jackson , Niall Martin , Graeme Smith , Mark O'Connor
发明人: Alan Ashworth , Stephen Jackson , Niall Martin , Graeme Smith , Mark O'Connor
IPC分类号: A61K31/50 , A61K31/44 , A61K31/415 , A01N43/00
CPC分类号: A61K31/366 , A61K31/405 , A61K31/4184 , A61K31/4706 , A61K31/473 , A61K31/502 , A61K31/517 , A61K31/522 , A61K31/675 , Y02A50/473
摘要: The present invention relates to the recognition that inhibition of the base excision repair pathway is selectively lethal in cells which are deficient in HR dependent DNA DSB repair. Methods and means relating to the treatment of cancers which are deficient in HR dependent DNA DSB repair using inhibitors which target base excision repair components, such as PARP, is provided herein.
摘要翻译: 本发明涉及对在HR依赖性DNA DSB修复缺陷的细胞中碱基切除修复途径的抑制选择性致死的认识。 本文提供了使用靶向基础切除修复组分(如PARP)的抑制剂治疗缺乏HR依赖性DNA DSB修复的癌症治疗方法和手段。
-
公开(公告)号:US5140764A
公开(公告)日:1992-08-25
申请号:US724109
申请日:1985-04-17
申请人: Mark O'Connor
发明人: Mark O'Connor
CPC分类号: B42F7/02 , G03B21/64 , Y10T428/24769 , Y10T428/26
摘要: A multi-channel transparent jacket for accommodating strips of microfilm to create a microfiche, the jacket having non-blocking characteristics, thereby minimizing the tendency of one jacket in a stack thereof to stick to an adjacent jacket. The jacket is constituted by front and rear panels formed of flexible polyethylene terephthalate film joined together by a parallel array of ribs to define the channels. The exposed surfaces of the panels have a friction-reducing layer thereon constituted by a multiplicity of discrete silicon dioxide nodules bonded to the film, the nodule shape approximating a surface segment of a sphere. The peaks of the segments form microscopic contact points which are bonded by molecular attraction to an abutting panel when the jacket is juxtaposed against a like jacket in frictional relationship thereto. The nodules have a relatively large average diameter whereby the population density thereof in a unit area of the layer produces multiple contact points resulting in a coefficient of friction whose value imparts non-blocking characteristics to the jacket to a degree permitting tangential displacement thereof with a like jacket sticking thereto.
摘要翻译: 一种多通道透明护套,用于容纳微缩胶卷条以产生缩微胶片,该夹克具有非阻挡特性,从而最小化其一个夹套在其叠层中粘附到相邻护套上的趋势。 护套由前后面板组成,前面板和后面板由柔性聚对苯二甲酸乙二醇酯薄膜组成,通过平行排列的棱线连接在一起,以限定通道。 面板的暴露表面在其上具有摩擦减小层,由多个离散的二氧化硅结块构成,其结合到膜上,结节形状接近球体的表面段。 这些段的峰形成微小的接触点,当夹套与其摩擦关系的相似的夹套并置时,它们通过分子吸引而与邻接面板结合。 结节具有相对较大的平均直径,由此其在该层的单位面积中的群体密度产生多个接触点,导致摩擦系数,其值赋予护套非阻塞特性至允许其与其相切的位移的程度 贴在其上的夹克
-
公开(公告)号:US4497128A
公开(公告)日:1985-02-05
申请号:US174900
申请日:1980-08-04
申请人: Mark O'Connor
发明人: Mark O'Connor
CPC分类号: B42F15/0005
摘要: A single-channel microfiche master housing a strip of microfilm containing one or more frames of reduced scale images, the master being manipulatable in one axial direction only by optical readers and other microfiche-handling machines. The master is constituted by a rectangular tab having a pair of keyhole notches at spaced positions in the lower edge thereof and a single channel transparent jacket accommodating the microfilm strip, one end of the jacket being secured to the tab at a position intermediate the notches to form a T-shaped structure. The microfiche master may be stored in a standard pull-out drawer by a raised pair of rails which is bridged by the tab, the rails passing through the notches whereby the jacket is suspended therebelow in the drawer.
摘要翻译: 单通道缩微胶片主机容纳包含一个或多个缩小比例图像的微缩胶片,该主机仅在光学读取器和其它缩微胶片处理机器的一个轴向方向上可操作。 主机由在其下边缘处的间隔位置处具有一对键孔凹口的矩形凸片和容纳微缩胶片条的单通道透明夹克构成,该夹套的一端在凹口至中间的位置固定到凸片 形成T形结构。 缩微胶片主机可以通过凸起的一对轨道存储在标准的拉出抽屉中,凸起的一对导轨通过凸片桥接,导轨穿过凹口,由此夹套在其下方悬挂在抽屉中。
-
-
-