发明授权
- 专利标题： Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
- 专利标题（中）： 11-β-羟基类固醇脱氢酶抑制剂1
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申请号： US12297910申请日： 2007-04-25
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公开(公告)号： US08148534B2公开(公告)日： 2012-04-03
- 发明人: Renhua Li , Owen Brendan Wallace , Yanping Xu
- 申请人： Renhua Li , Owen Brendan Wallace , Yanping Xu
- 申请人地址： US IN Indianapolis
- 专利权人： Eli Lilly and Company
- 当前专利权人： Eli Lilly and Company
- 当前专利权人地址： US IN Indianapolis
- 代理商 Dan L. Wood
- 国际申请： PCT/US2007/067353 WO 20070425
- 国际公布： WO2007/127765 WO 20071108
- 主分类号： C07D405/00
- IPC分类号： C07D405/00 ; A61K31/445
摘要：
The present invention discloses novel compounds of Formula I: (I) possessing 11β-HSD type 1 antagonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I, as well as methods of using the compounds and compositions to treat diabetes, hyperglycemia, obesity, hypertension, hyperlipidemia, metabolic syndrome, cognitive disorders, and other conditions associated with 11β-HSD type 1 activity.
公开/授权文献
- US20090275613A1 INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 公开/授权日：2009-11-05
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