发明授权
US08158622B2 Pyrrolopyridine-2-carboxylic acid amide inhibitors of glycogen phosphorylase
有权
糖基磷酸化酶的吡咯并吡啶-2-羧酸酰胺抑制剂
- 专利标题： Pyrrolopyridine-2-carboxylic acid amide inhibitors of glycogen phosphorylase
- 专利标题（中）： 糖基磷酸化酶的吡咯并吡啶-2-羧酸酰胺抑制剂
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申请号： US12217157申请日： 2008-07-02
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公开(公告)号： US08158622B2公开(公告)日： 2012-04-17
- 发明人: Stuart Edward Bradley , Thomas Martin Krulle , Peter John Murray , Martin James Procter , Robert John Rowley , Colin Peter Sambrook Smith , Gerard Hugh Thomas , Karen Lesley Schofield
- 申请人： Stuart Edward Bradley , Thomas Martin Krulle , Peter John Murray , Martin James Procter , Robert John Rowley , Colin Peter Sambrook Smith , Gerard Hugh Thomas , Karen Lesley Schofield
- 申请人地址： GB Oxford
- 专利权人： Prosidion Limited
- 当前专利权人： Prosidion Limited
- 当前专利权人地址： GB Oxford
- 代理机构： Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C.
- 代理商 Ivor R. Elrifi; Heidi A. Erlacher
- 主分类号： C07D471/02
- IPC分类号： C07D471/02 ; A61K31/44
摘要：
Compounds represented by Formula (I): or pharmaceutically acceptable salts thereof, are inhibitors of glycogen phosphorylase and are useful in the prophylactic or therapeutic treatment of diabetes, hyperglycemia, hypercholesterolemia, hyperinsulinemia, hyperlipidemia, hypertension, atherosclerosis or tissue ischemia e.g. myocardial ischemia, and as cardioprotectants.
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