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公开(公告)号：US07884112B2
公开(公告)日：2011-02-08
申请号：US10591895
申请日：2007-11-05
Applicant: Stuart Edward Bradley , Revathy Perpetua Jeevaratnam , Thomas Martin Krulle , Martin James Procter , Robert John Rowley , Gerard Hugh Thomas , Ana Valdesabril
Inventor： Stuart Edward Bradley , Revathy Perpetua Jeevaratnam , Thomas Martin Krulle , Martin James Procter , Robert John Rowley , Gerard Hugh Thomas , Ana Valdesabril
IPC: A61K31/437 , C07D471/04
CPC classification number: C07D471/04
Abstract: Compounds of Formula (I) or pharmaceutically acceptable salts thereof, are inhibitors of glycogen phosphorylase and are useful in the prophylactic or therapeutic treatment of diabetes, hyperglycemia, hypercholesterolemia, hyperinsulinemia, hyperlipidemia, hypertension, atherosclerosis or tissue ischemia e.g. myocardial ischemia, or as cardioprotectants or inhibitors of abnormal cell growth.
Abstract translation: 式（I）化合物或其药学上可接受的盐是糖原磷酸化酶的抑制剂，可用于预防或治疗糖尿病，高血糖症，高胆固醇血症，高胰岛素血症，高脂血症，高血压，动脉粥样硬化或组织缺血。 心肌缺血或作为心脏保护剂或异常细胞生长的抑制剂。
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2.发明申请BICYCLIC ARYL AND HETEROARYL COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS 失效用于治疗代谢性疾病的双相ARYL和HETEROARYL化合物公开(公告)号：US20100173886A1
公开(公告)日：2010-07-08
申请号：US12601100
申请日：2008-05-22
Applicant: Jason Bloxham , Stuart Edward Bradley , Tom Banksia Dupree , Peter Timothy Fry , Patrick Eric Hanrahan , Thomas Martin Krulle , Martin James Procter , Colin Peter Sambrook-Smith , Karen Lesley Schofield , Donald Smyth , Alan John Stewart
Inventor： Jason Bloxham , Stuart Edward Bradley , Tom Banksia Dupree , Peter Timothy Fry , Patrick Eric Hanrahan , Thomas Martin Krulle , Martin James Procter , Colin Peter Sambrook-Smith , Karen Lesley Schofield , Donald Smyth , Alan John Stewart
IPC: A61K31/397 , C07D213/84 , A61K31/44 , C07D217/22 , A61K31/47 , C07D403/12 , A61K31/496 , C07D413/12 , A61K31/5377 , A61P3/10 , A61P9/12 , A61P25/24 , A61P25/32 , A61P25/36
CPC classification number: C07D213/62 , C07D401/12 , C07D405/12 , C07D409/12
Abstract: Compounds of formula (I): or pharmaceutically acceptable salts thereof, are opioid receptor modulators, e.g. mu-opioid receptor antagonists, neutral antagonists or inverse agonists, and are useful for the treatment of metabolic disorders including obesity.
Abstract translation: 式（I）化合物或其药学上可接受的盐是阿片样物质受体调节剂，例如 μ-阿片受体拮抗剂，中性拮抗剂或反向激动剂，并且可用于治疗包括肥胖症在内的代谢紊乱。
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公开(公告)号：US20090221644A1
公开(公告)日：2009-09-03
申请号：US11922830
申请日：2006-06-29
Applicant: Stuart Edward Bradley , Matthew Colin Thor Fyfe , Lisa Sarah Bertram , William Gattrell , Martin James Procter , Chrystelle Marie Rasamison , Colin Peter Sambrook-Smith , Vilasben Kanji Shah , David French Stonehouse , Simon Andrew Swain , Gerard Hugh Thomas
Inventor： Stuart Edward Bradley , Matthew Colin Thor Fyfe , Lisa Sarah Bertram , William Gattrell , Martin James Procter , Chrystelle Marie Rasamison , Colin Peter Sambrook-Smith , Vilasben Kanji Shah , David French Stonehouse , Simon Andrew Swain , Gerard Hugh Thomas
IPC: A61K31/443 , C07D405/12 , A61P3/10
CPC classification number: C07D471/04 , C07D405/06 , C07D405/12 , C07D413/14 , C07D417/14 , C07D495/04
Abstract: Compounds of formula (I): or pharmaceutically acceptable salts thereof, are GPCR agonists and are useful as for the treatment of obesity and diabetes.
Abstract translation: 式（I）化合物或其药学上可接受的盐是GPCR激动剂，可用于治疗肥胖症和糖尿病。
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4.发明申请Pyrrolopyridine-2-carboxylic acid amide inhibitors of glycogen phosphorylase 有权糖基磷酸化酶的吡咯并吡啶-2-羧酸酰胺抑制剂公开(公告)号：US20090023703A1
公开(公告)日：2009-01-22
申请号：US12217157
申请日：2008-07-02
Applicant: Stuart Edward Bradley , Thomas Martin Krulle , Peter John Murray , Martin James Procter , Robert John Rowley , Colin Peter Sambrook Smith , Gerard Hugh Thomas
Inventor： Stuart Edward Bradley , Thomas Martin Krulle , Peter John Murray , Martin James Procter , Robert John Rowley , Colin Peter Sambrook Smith , Gerard Hugh Thomas
IPC: A61K31/437 , C07D471/04 , A61K31/5377 , C07D263/04 , A61P3/10
CPC classification number: C07D471/04
Abstract: Compounds represented by Formula (I): or pharmaceutically acceptable salts thereof, are inhibitors of glycogen phosphorylase and are useful in the prophylactic or therapeutic treatment of diabetes, hyperglycemia, hypercholesterolemia, hyperinsulinemia, hyperlipidemia, hypertension, atherosclerosis or tissue ischemia e.g. myocardial ischemia, and as cardioprotectants.
Abstract translation: 由式（I）表示的化合物或其药学上可接受的盐是糖原磷酸化酶的抑制剂，可用于预防或治疗糖尿病，高血糖症，高胆固醇血症，高胰岛素血症，高脂血症，高血压，动脉粥样硬化或组织缺血。 心肌缺血，以及心脏保护剂。
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公开(公告)号：US20090005391A1
公开(公告)日：2009-01-01
申请号：US12091947
申请日：2006-11-03
Applicant: Matthew Colin Thor Fyfe , Martin James Procter
Inventor： Matthew Colin Thor Fyfe , Martin James Procter
IPC: A61K31/4433 , A61P3/00 , A61P3/10 , C07D405/12 , C07D413/12 , C07D417/12 , A61K31/497 , A61K31/506 , A61K31/4155 , A61K31/501 , A61K31/427 , A61K31/422
CPC classification number: C07D405/12 , C07D413/12 , C07D417/12
Abstract: Compounds of Formula (I) or pharmaceutically acceptable salts thereof, are useful in the prophylactic and therapeutic treatment of hyperglycemia and diabetes.
Abstract translation: 式（I）化合物或其药学上可接受的盐可用于预防和治疗高血糖症和糖尿病。
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Patent Agency Ranking
6.发明授权Pyrrolopyridine-2-carboxylic acid amide inhibitors of glycogen phosphorylase 有权糖基磷酸化酶的吡咯并吡啶-2-羧酸酰胺抑制剂公开(公告)号：US07405210B2
公开(公告)日：2008-07-29
申请号：US10851902
申请日：2004-05-20
Applicant: Stuart Edward Bradley , Thomas Martin Krulle , Peter John Murray , Martin James Procter , Robert John Rowley , Colin Peter Sambrook Smith , Gerard Hugh Thomas
Inventor： Stuart Edward Bradley , Thomas Martin Krulle , Peter John Murray , Martin James Procter , Robert John Rowley , Colin Peter Sambrook Smith , Gerard Hugh Thomas
IPC: C07D471/02 , A61K31/44
CPC classification number: C07D471/04
Abstract: Compounds represented by Formula (I): or pharmaceutically acceptable salts thereof, are inhibitors of glycogen phosphorylase and are useful in the prophylactic or therapeutic treatment of diabetes, hyperglycemia, hypercholesterolemia, hyperinsulinemia, hyperlipidemia, hypertension, atherosclerosis or tissue ischemia e.g. myocardial ischemia, and as cardioprotectants.
Abstract translation: 由式（I）表示的化合物或其药学上可接受的盐是糖原磷酸化酶的抑制剂，可用于预防或治疗糖尿病，高血糖症，高胆固醇血症，高胰岛素血症，高脂血症，高血压，动脉粥样硬化或组织缺血。 心肌缺血，以及心脏保护剂。
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公开(公告)号：US07338979B2
公开(公告)日：2008-03-04
申请号：US10766078
申请日：2004-01-28
Applicant: Martin James Procter , William Thomas Gattrell
Inventor： Martin James Procter , William Thomas Gattrell
IPC: A61K31/045 , A61K31/05
CPC classification number: A61Q19/02 , A61K8/347 , A61K31/05 , C07B2200/13 , C07C39/17
Abstract: The present invention is directed to 4-cyclopentyl resorcinol monohydrate, its Form I polymorph, formulations containing at least one of these compounds, and their use to lighten skin.
Abstract translation: 本发明涉及4-环戊基间苯二酚一水合物，其I型多晶型物，含有这些化合物中的至少一种的制剂及其减轻皮肤的用途。
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公开(公告)号：US07009052B2
公开(公告)日：2006-03-07
申请号：US10801910
申请日：2004-03-16
Applicant: Daniel Y. Du , Matthew Colin Thor Fyfe , Martin James Procter , Karen Lesley Schofield , Vilasben Kanji Shah , Geoffrey Martyn Williams
Inventor： Daniel Y. Du , Matthew Colin Thor Fyfe , Martin James Procter , Karen Lesley Schofield , Vilasben Kanji Shah , Geoffrey Martyn Williams
IPC: C07D215/16 , C07D311/74 , A61K31/47
CPC classification number: C07D215/38 , C07D215/36 , C07D215/40 , C07D311/14 , C07D401/12 , C07D405/12 , C07D409/12
Abstract: The present invention is directed to a new class of 6-sulfonamide quinoline and chromene derivative and to their use as androgen antagonists.
Abstract translation: 本发明涉及一类新的6-磺酰胺喹啉和色烯衍生物及其作为雄激素拮抗剂的用途。
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公开(公告)号：US06828460B2
公开(公告)日：2004-12-07
申请号：US10020037
申请日：2001-12-21
Applicant: Andrew Francis Browning , Eric William Collington , Martin James Procter , Joanna Victoria Geden
Inventor： Andrew Francis Browning , Eric William Collington , Martin James Procter , Joanna Victoria Geden
IPC: C07C24900
CPC classification number: C07D295/096 , A61K8/347 , A61K8/35 , A61K8/40 , A61K8/41 , A61K8/466 , A61K8/49 , A61K8/494 , A61K8/69 , A61Q19/02 , C07C69/013 , C07C69/76 , C07C215/64 , C07C233/23 , C07C235/40 , C07C251/44 , C07C259/08 , C07C271/24 , C07C271/36 , C07C311/07 , C07C317/20 , C07C323/17 , C07C2601/08 , C07C2601/14
Abstract: The present invention relates to the use of certain resorcinol derivatives as skin lightening agents.
Abstract translation: 本发明涉及某些间苯二酚衍生物作为增白剂的用途。
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10.发明授权Bicyclic aryl and heteroaryl compounds for the treatment of metabolic disorders 失效用于治疗代谢紊乱的双环芳基和杂芳基化合物公开(公告)号：US08278442B2
公开(公告)日：2012-10-02
申请号：US12601100
申请日：2008-05-22
Applicant: Jason Bloxham , Stuart Edward Bradley , Tom Banksia Dupree , Peter Timothy Fry , Patrick Eric Hanrahan , Thomas Martin Krulle , Martin James Procter , Colin Peter Sambrook-Smith , Karen Lesley Schofield , Donald Smyth , Alan John Stewart
Inventor： Jason Bloxham , Stuart Edward Bradley , Tom Banksia Dupree , Peter Timothy Fry , Patrick Eric Hanrahan , Thomas Martin Krulle , Martin James Procter , Colin Peter Sambrook-Smith , Karen Lesley Schofield , Donald Smyth , Alan John Stewart
IPC: C07D213/84 , C07D217/22 , C07D403/12 , C07D413/12
CPC classification number: C07D213/62 , C07D401/12 , C07D405/12 , C07D409/12
Abstract: Compounds of formula (I): or pharmaceutically acceptable salts thereof, are opioid receptor modulators, e.g. mu-opioid receptor antagonists, neutral antagonists or inverse agonists, and are useful for the treatment of metabolic disorders including obesity.
Abstract translation: 式（I）化合物或其药学上可接受的盐是阿片样物质受体调节剂，例如 μ-阿片受体拮抗剂，中性拮抗剂或反向激动剂，并且可用于治疗包括肥胖症在内的代谢紊乱。
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