发明授权
- 专利标题： Hydroxyalkyl substituted imidazoquinoline compounds and methods
- 专利标题（中）： 羟基烷基取代的咪唑并喹啉化合物和方法
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申请号： US11885006申请日： 2006-02-22
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公开(公告)号： US08158794B2公开(公告)日： 2012-04-17
- 发明人: Tushar A. Kshirsagar , Bryon A. Merrill , Shri Niwas , Gregory D. Lundquist, Jr. , Philip D. Heppner , Michael E. Danielson
- 申请人： Tushar A. Kshirsagar , Bryon A. Merrill , Shri Niwas , Gregory D. Lundquist, Jr. , Philip D. Heppner , Michael E. Danielson
- 申请人地址： US MN St. Paul
- 专利权人： 3M Innovative Properties Company
- 当前专利权人： 3M Innovative Properties Company
- 当前专利权人地址： US MN St. Paul
- 国际申请： PCT/US2006/006042 WO 20060222
- 国际公布： WO2006/091567 WO 20060831
- 主分类号： C07D471/00
- IPC分类号： C07D471/00 ; A61K31/535
摘要：
Certain imidazoquinolines with a hydroxymethyl or hydroxyethyl substituent at the 2-position, and an aryl or heteroaryl substituent at the 7-position, pharmaceutical compositions containing the compounds, intermediates, methods of making and methods of use of these compounds as immunomodulators, for preferentially inducing IFN-α biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.
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