Invention Grant
US08163889B2 Physiologically active polypeptide conjugate having prolonged in vivo half-life
有权
具有延长体内半衰期的生理活性多肽缀合物
- Patent Title: Physiologically active polypeptide conjugate having prolonged in vivo half-life
- Patent Title (中): 具有延长体内半衰期的生理活性多肽缀合物
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Application No.: US12603757Application Date: 2009-10-22
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Publication No.: US08163889B2Publication Date: 2012-04-24
- Inventor: Young-Min Kim , Dae-Jin Kim , Sung-Min Bae , Chang-Ki Lim , Se-Chang Kwon , Gwan-Sun Lee
- Applicant: Young-Min Kim , Dae-Jin Kim , Sung-Min Bae , Chang-Ki Lim , Se-Chang Kwon , Gwan-Sun Lee
- Applicant Address: KR Seoul
- Assignee: Hanmi Holdings Co., Ltd.
- Current Assignee: Hanmi Holdings Co., Ltd.
- Current Assignee Address: KR Seoul
- Agency: Sughrue Mion, PLLC
- Priority: KR2003-0015744 20030313; KR2003-0036408 20030605
- Main IPC: C07K16/00
- IPC: C07K16/00
Abstract:
A protein conjugate having a prolonged in vivo half-life of a physiological activity, comprising i) a physiologically active polypeptide, ii) a non-peptidic polymer, and iii) an immunoglobulin, is useful for the development of a polypeptide drug due to the enhanced in vivo stability and prolonged half-life in blood, while reducing the possibility of inducing an immune response.
Public/Granted literature
- US20100105869A1 Physiologically Active Polypeptide Conjugate Having Prolonged In Vivo Half-Life Public/Granted day:2010-04-29
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