A specimen slicing guide for use in slicing a biopsy specimen taken from a human patient or an animal patient includes a base extending in a longitudinal direction. A plurality of needles extends substantially perpendicularly to the base and the needles are spaced along the longitudinal direction of the base. Two specimen slicing guides are coupled via at least one link, which is adapted to allow an adjustable spacing of the two specimen slicing guides in a parallel relationship. A method of cutting a biopsy specimen includes fixing the biopsy specimen relative to a support surface using the needles of two, parallel-arranged specimen slicing guides, inserting a cutting tool between corresponding needle gap pairs and then downwardly moving the cutting tool under guidance of adjacent needles.