Invention Grant
US08193183B2 2,6-substituted-4-monosubstitutedamino-pyrimidine as prostaglandin D2 receptor antagonists
有权
2,6-取代-4-单取代氨基嘧啶作为前列腺素D2受体拮抗剂
- Patent Title: 2,6-substituted-4-monosubstitutedamino-pyrimidine as prostaglandin D2 receptor antagonists
- Patent Title (中): 2,6-取代-4-单取代氨基嘧啶作为前列腺素D2受体拮抗剂
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Application No.: US11735751Application Date: 2007-04-16
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Publication No.: US08193183B2Publication Date: 2012-06-05
- Inventor: Sungtaek Lim , Keith John Harris , David Stefany , Charles J. Gardner , Bin Cao , Ray Boffey , Timothy A. Gillespy , Joacy C. Aguiar , Hazel J. Dyke , Elsa A. Dechaux
- Applicant: Sungtaek Lim , Keith John Harris , David Stefany , Charles J. Gardner , Bin Cao , Ray Boffey , Timothy A. Gillespy , Joacy C. Aguiar , Hazel J. Dyke , Elsa A. Dechaux
- Applicant Address: US NJ Bridgewater
- Assignee: Aventis Pharmaceuticals Inc.
- Current Assignee: Aventis Pharmaceuticals Inc.
- Current Assignee Address: US NJ Bridgewater
- Agent Ronald G. Ort
- Main IPC: C07D239/47
- IPC: C07D239/47 ; C07D413/12 ; A61K31/505 ; A61K31/5355 ; A61P37/00 ; A61P37/08 ; A61P17/00

Abstract:
The present invention is directed to a compound of Formula (I) wherein Cy1, Cy2, L1, L2, and R1 are as defined herein, a pharmaceutical composition comprising a pharmaceutically effective amount of one or more compounds according to Formula (I) in admixture with a pharmaceutically acceptable carrier, and a method of treating a patient suffering from a PGD2-mediated disorder including, but not limited to, allergic disease (such as allergic rhinitis, allergic conjunctivitis, atopic dermatitis, bronchial asthma and food allergy), systemic mastocytosis, disorders accompanied by systemic mast cell activation, anaphylaxis shock, bronchoconstriction, bronchitis, urticaria, eczema, diseases accompanied by itch (such as atopic dermatitis and urticaria), diseases (such as cataract, retinal detachment, inflammation, infection and sleeping disorders) which is generated secondarily as a result of behavior accompanied by itch (such as scratching and beating), inflammation, chronic obstructive pulmonary diseases, ischemic reperfusion injury, cerebrovascular accident, chronic rheumatoid arthritis, pleurisy, ulcerative colitis and the like by administering to said patient a pharmaceutically effective amount of a compound according to Formula (I).
Public/Granted literature
- US20070244131A1 2,6-SUBSTITUTED-4-MONOSUBSTITUTEDAMINO-PYRIMIDINE AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS Public/Granted day:2007-10-18
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