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US08193408B2 Nematodes as model organisms for the investigation of neurodegenerative diseases, in particular parkinsons disease, uses and methods for the discovery of substances and genes which can used in the treatment of the above disease states and identification of a nematode gene 失效
线虫作为用于调查神经变性疾病，特别是帕金森病的模型生物体，用于发现可用于治疗上述疾病状态和鉴定线虫基因的物质和基因的用途和方法

Nematodes as model organisms for the investigation of neurodegenerative diseases, in particular parkinsons disease, uses and methods for the discovery of substances and genes which can used in the treatment of the above disease states and identification of a nematode gene
Abstract:
The invention relates to nematodes as model organisms for the investigation of neurodegenerative diseases, in particular, Parkinsons disease, uses and methods for the discovery of substances and genes which can be used in the treatment of the above disease states and identification of a nematode gene, From C elegans, which is homologous to the human parkin gene associated with Parkinsons disease. The invention further relates to those nematodes which contain an aberrant or missing expression of at least one gene, preferably a parkin gene and/or a α-synucleine gene, which is connected with Parkinsons disease. According to the invention, the above organisms can be used for the identification and characterization of medicaments for the treatment of said disease states.
Abstract(Chinese):

本发明涉及线虫作为用于研究神经变性疾病的模型生物，特别是帕金森病，用于发现可用于治疗上述疾病状态和鉴定线虫基因的物质和基因的用途和方法， 来自线虫，其与与帕金森病相关的人类parkin基因同源。 本发明还涉及含有与帕金森病相关的至少一种基因，优选parkin基因和/或α-突触核蛋白基因的异常或缺失表达的线虫。 根据本发明，上述生物体可用于鉴定和表征用于治疗所述疾病状态的药物。

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