发明授权
- 专利标题: Amide derivatives and medicinal use thereof
- 专利标题(中): 酰胺衍生物及其药用
-
申请号: US12458095申请日: 2009-06-30
-
公开(公告)号: US08198454B2公开(公告)日: 2012-06-12
- 发明人: Mitsuharu Nakamura , Takao Kamahori , Seigo Ishibuchi , Yoichi Naka , Hiroshi Sumichika , Katsuhiko Itoh
- 申请人: Mitsuharu Nakamura , Takao Kamahori , Seigo Ishibuchi , Yoichi Naka , Hiroshi Sumichika , Katsuhiko Itoh
- 申请人地址: JP Osaka-shi
- 专利权人: Mitsubishi Tanabe Pharma Corporation
- 当前专利权人: Mitsubishi Tanabe Pharma Corporation
- 当前专利权人地址: JP Osaka-shi
- 代理机构: Oblon, Spivak, McClelland, Maier & Neustadt, L.L.P.
- 优先权: JP2000-280540 20000914; JP2000-386813 20001220
- 主分类号: C07D401/00
- IPC分类号: C07D401/00 ; A61K31/44
摘要:
The present invention relates to an amide derivative of the formula (1), having a C5a receptor antagonistic action wherein each symbol is as defined in the specification. The above-mentioned amide derivative, an optically active form thereof and a pharmaceutically acceptable salt thereof are promising as an agent for the treatment or prophylaxis of diseases or syndromes caused by inflammation caused by C5a [e.g., autoimmune diseases such as rheumatism, systemic lupus erythematosus and the like, sepsis, adult respiratory distress syndrome, chronic obstructive pulmonary disease, allergic diseases such as asthma and the like, atherosclerosis, cardiac infarction, brain infarction, psoriasis, Alzheimer's disease and serious organ injury (e.g., pneumonia, nephritis, hepatitis and pancreatitis and the like) due to activation of leukocytes caused by ischemia reperfusion, trauma, burn, surgical invasion and the like]. Moreover, they are useful as a therapeutic or prophylactic agent for the infectious diseases caused by bacteria and virus that invade via a C5a receptor.
公开/授权文献
- US20100041656A1 Novel amide derivatives and medicinal use thereof 公开/授权日:2010-02-18