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公开(公告)号:US07855297B2
公开(公告)日:2010-12-21
申请号:US10380502
申请日:2001-09-14
申请人: Mitsuharu Nakamura , Takao Kamahori , Seigo Ishibuchi , Yoichi Naka , Hiroshi Sumichika , Katsuhiko Itoh
发明人: Mitsuharu Nakamura , Takao Kamahori , Seigo Ishibuchi , Yoichi Naka , Hiroshi Sumichika , Katsuhiko Itoh
IPC分类号: C07D401/00 , A61K31/44
CPC分类号: C07D213/40 , C07C233/59 , C07C233/60 , C07C233/62 , C07C235/40 , C07C255/29 , C07C255/60 , C07C317/32 , C07C317/40 , C07C323/40 , C07C327/46 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07C2602/12 , C07D213/64 , C07D213/65 , C07D213/69 , C07D213/74 , C07D213/75 , C07D215/50 , C07D231/12 , C07D233/56 , C07D249/08 , C07D277/28 , C07D295/13 , C07D295/135 , C07D295/185 , C07D309/12 , C07D311/04 , C07D311/66 , C07D317/58 , C07D317/66 , C07D319/18 , C07D333/20 , C07D333/36 , C07D335/06 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/06 , C07D409/14 , C07D417/12 , C07D417/14 , C07D513/04
摘要: The present invention relates to an amide derivative of the formula (1), having a C5a receptor antagonistic action wherein each symbol is as defined in the specification. The above-mentioned amide derivative, an optically active form thereof and a pharmaceutically acceptable salt thereof are promising as an agent for the treatment or prophylaxis of diseases or syndromes caused by inflammation caused by C5a [e.g., autoimmune diseases such as rheumatism, systemic lupus erythematosus and the like, sepsis, adult respiratory distress syndrome, chronic obstructive pulmonary disease, allergic diseases such as asthma and the like, atherosclerosis, cardiac infarction, brain infarction, psoriasis, Alzheimer's disease and serious organ injury (e.g., pneumonia, nephritis, hepatitis and pancreatitis and the like) due to activation of leukocytes caused by ischemia reperfusion, trauma, burn, surgical invasion and the like]. Moreover, they are useful as a therapeutic or prophylactic agent for the infectious diseases caused by bacteria and virus that invade via a C5a receptor.
摘要翻译: 本发明涉及具有C5a受体拮抗作用的式(1)的酰胺衍生物,其中每个符号如说明书中所定义。 上述酰胺衍生物,其光学活性形式和其药学上可接受的盐有望用作治疗或预防由C5a引起的炎症引起的疾病或综合征的药物[例如,自身免疫疾病如风湿病,系统性红斑狼疮 败血症,成人呼吸窘迫综合征,慢性阻塞性肺病,哮喘等过敏性疾病,动脉粥样硬化,心肌梗死,脑梗塞,牛皮癣,阿尔茨海默病和严重器官损伤(例如肺炎,肾炎,肝炎和 胰腺炎等)由于由缺血再灌注,创伤,烧伤,手术入侵等引起的白细胞的活化]。 此外,它们可用作由通过C5a受体侵入的细菌和病毒引起的感染性疾病的治疗或预防剂。
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公开(公告)号:US08198454B2
公开(公告)日:2012-06-12
申请号:US12458095
申请日:2009-06-30
申请人: Mitsuharu Nakamura , Takao Kamahori , Seigo Ishibuchi , Yoichi Naka , Hiroshi Sumichika , Katsuhiko Itoh
发明人: Mitsuharu Nakamura , Takao Kamahori , Seigo Ishibuchi , Yoichi Naka , Hiroshi Sumichika , Katsuhiko Itoh
IPC分类号: C07D401/00 , A61K31/44
CPC分类号: C07D213/40 , C07C233/59 , C07C233/60 , C07C233/62 , C07C235/40 , C07C255/29 , C07C255/60 , C07C317/32 , C07C317/40 , C07C323/40 , C07C327/46 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07C2602/12 , C07D213/64 , C07D213/65 , C07D213/69 , C07D213/74 , C07D213/75 , C07D215/50 , C07D231/12 , C07D233/56 , C07D249/08 , C07D277/28 , C07D295/13 , C07D295/135 , C07D295/185 , C07D309/12 , C07D311/04 , C07D311/66 , C07D317/58 , C07D317/66 , C07D319/18 , C07D333/20 , C07D333/36 , C07D335/06 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/06 , C07D409/14 , C07D417/12 , C07D417/14 , C07D513/04
摘要: The present invention relates to an amide derivative of the formula (1), having a C5a receptor antagonistic action wherein each symbol is as defined in the specification. The above-mentioned amide derivative, an optically active form thereof and a pharmaceutically acceptable salt thereof are promising as an agent for the treatment or prophylaxis of diseases or syndromes caused by inflammation caused by C5a [e.g., autoimmune diseases such as rheumatism, systemic lupus erythematosus and the like, sepsis, adult respiratory distress syndrome, chronic obstructive pulmonary disease, allergic diseases such as asthma and the like, atherosclerosis, cardiac infarction, brain infarction, psoriasis, Alzheimer's disease and serious organ injury (e.g., pneumonia, nephritis, hepatitis and pancreatitis and the like) due to activation of leukocytes caused by ischemia reperfusion, trauma, burn, surgical invasion and the like]. Moreover, they are useful as a therapeutic or prophylactic agent for the infectious diseases caused by bacteria and virus that invade via a C5a receptor.
摘要翻译: 本发明涉及具有C5a受体拮抗作用的式(1)的酰胺衍生物,其中每个符号如说明书中所定义。 上述酰胺衍生物,其光学活性形式和其药学上可接受的盐有望用作治疗或预防由C5a引起的炎症引起的疾病或综合征的药物[例如,自身免疫疾病如风湿病,系统性红斑狼疮 败血症,成人呼吸窘迫综合征,慢性阻塞性肺病,哮喘等过敏性疾病,动脉粥样硬化,心肌梗死,脑梗塞,牛皮癣,阿尔茨海默病和严重器官损伤(例如肺炎,肾炎,肝炎和 胰腺炎等)由于由缺血再灌注,创伤,烧伤,手术入侵等引起的白细胞的活化]。 此外,它们可用作由通过C5a受体侵入的细菌和病毒引起的感染性疾病的治疗或预防剂。
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公开(公告)号:US20100152261A1
公开(公告)日:2010-06-17
申请号:US11996922
申请日:2006-07-25
申请人: Hideyuki Aizawa , Makoto Seki , Jun-ichi Endoh , Minoru Tanaka , Naoto Fujie , Osamu Sakuma , Takao Kamahori
发明人: Hideyuki Aizawa , Makoto Seki , Jun-ichi Endoh , Minoru Tanaka , Naoto Fujie , Osamu Sakuma , Takao Kamahori
IPC分类号: A61K31/4196 , A61K31/4164 , C07D249/08 , C07D233/66 , C07D233/56 , A61P9/00 , A61P1/00 , A61P11/00 , A61P13/00 , A61P25/00
CPC分类号: C07D233/56 , C07D233/18 , C07D233/60 , C07D233/61 , C07D249/08 , C07D407/06
摘要: A nitrogen-containing heterocyclic derivative represented by the following general formula (I), or a hydrate or solvate thereof, which has a selective antagonistic action on the muscarinic M3 receptor and causes reduced cardiac side effect and thus is safe, and has superior pharmacological efficacy and prolonged action even by inhalation administration, and a pharmaceutical composition comprising the compound and a pharmaceutically acceptable carrier.
摘要翻译: 由以下通式(I)表示的含氮杂环衍生物或其水合物或溶剂化物,其对毒蕈碱性M3受体具有选择性拮抗作用并引起心脏副作用降低,因此是安全的,并且具有优异的药理功效 以及甚至通过吸入给药延长的作用,以及包含该化合物和药学上可接受的载体的药物组合物。
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