发明授权
- 专利标题： Leucine-based motif and clostridial neurotoxins
- 专利标题（中）： 基于亮氨酸的主题和梭菌神经毒素
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申请号： US12416470申请日： 2009-04-01
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公开(公告)号： US08206723B2公开(公告)日： 2012-06-26
- 发明人: Lance E. Steward , Ester Fernandez-Salas , Todd M. Herrington , Kei Roger Aoki
- 申请人： Lance E. Steward , Ester Fernandez-Salas , Todd M. Herrington , Kei Roger Aoki
- 申请人地址： US CA Irvine
- 专利权人： Allergan, Inc.
- 当前专利权人： Allergan, Inc.
- 当前专利权人地址： US CA Irvine
- 代理商 Kenton Abel; Debra Condino
- 主分类号： C07K14/33
- IPC分类号： C07K14/33
摘要：
Modified neurotoxin comprising neurotoxin including structural modification, wherein the structural modification alters the biological persistence, such as the biological half-life and/or a biological activity of the modified neurotoxin relative to an identical neurotoxin without the structural modification. In one embodiment, methods of making the modified neurotoxin include using recombinant techniques. In another embodiment, methods of using the modified neurotoxin to treat conditions include treating various disorders, neuromuscular aliments and pain.
公开/授权文献
- US20090202591A1 LEUCINE-BASED MOTIF AND CLOSTRIDIAL NEUROTOXINS 公开/授权日：2009-08-13
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