Invention Grant
- Patent Title: Orthogonal translation components for the in vivo incorporation of unnatural amino acids
- Patent Title (中): 用于体内引入非天然氨基酸的正交翻译组分
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Application No.: US11665083Application Date: 2005-10-27
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Publication No.: US08216804B2Publication Date: 2012-07-10
- Inventor: Peter G. Schultz , Jianming Xie , Huaqiang Zeng
- Applicant: Peter G. Schultz , Jianming Xie , Huaqiang Zeng
- Applicant Address: US CA La Jolla
- Assignee: The Scripps Research Institute
- Current Assignee: The Scripps Research Institute
- Current Assignee Address: US CA La Jolla
- Agency: Quine Intellectual Property Law Group, P.C.
- International Application: PCT/US2005/039210 WO 20051027
- International Announcement: WO2006/110182 WO 20061019
- Main IPC: C12N15/09
- IPC: C12N15/09 ; C12N1/21 ; C12N1/19
Abstract:
The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetases that can incorporate unnatural amino acids into proteins produced in eubacterial host cells such as E. coli, or in a eukaryotic host such as a yeast cell. The invention provides, for example but not limited to, novel orthogonal synthetases, methods for identifying and making the novel synthetases, methods for producing proteins containing unnatural amino acids, and translation systems.
Public/Granted literature
- US20080233611A1 Orthogonal Translation Components for the in Vivo Incorporation of Unnatural Amino Acids Public/Granted day:2008-09-25
Information query
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