Invention Grant
US08222375B2 Human monoclonal antibodies to protein tyrosine kinase 7 (PTK7) and methods for using anti-PTK7 antibodies
有权
蛋白酪氨酸激酶7（PTK7）的人单克隆抗体和使用抗PTK7抗体的方法
- Patent Title: Human monoclonal antibodies to protein tyrosine kinase 7 (PTK7) and methods for using anti-PTK7 antibodies
- Patent Title (中): 蛋白酪氨酸激酶7（PTK7）的人单克隆抗体和使用抗PTK7抗体的方法
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Application No.: US12095986Application Date: 2006-12-08
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Publication No.: US08222375B2Publication Date: 2012-07-17
- Inventor: Jonathan Alexander Terrett , Li-Sheng Lu , Chin Pan
- Applicant: Jonathan Alexander Terrett , Li-Sheng Lu , Chin Pan
- Applicant Address: US NJ Princeton
- Assignee: MEDAREX, Inc.
- Current Assignee: MEDAREX, Inc.
- Current Assignee Address: US NJ Princeton
- Agency: Nelson Mullins Riley & Scarborough LLP
- Agent Jane E. Remillard, Esq.; Jill Gorny Sloper, Esq.
- International Application: PCT/US2006/046837 WO 20061208
- International Announcement: WO2007/067730 WO 20070614
- Main IPC: C07K16/40
- IPC: C07K16/40 ; C07K16/00 ; A61K39/395
Abstract:
The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to PTK7 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for detecting PTK7, as well as methods for treating various diseases, including cancer and infectious diseases, using anti-PTK7 antibodies.
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