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    ANTIBODIES
    2.
    发明申请
    ANTIBODIES 审中-公开
    抗体

    公开(公告)号：US20120231004A1

    公开(公告)日：2012-09-13

    申请号：US13501921

    申请日：2010-10-13

    申请人： Christian Rohlff ,  Alasdair Stamps ,  Jonathan Alexander Terrett

    发明人： Christian Rohlff ,  Alasdair Stamps ,  Jonathan Alexander Terrett

    IPC分类号： C07K16/28 ,  A61P35/00 ,  A61K39/395

    CPC分类号： C07K16/2866 ,  C07K2317/77

    摘要： The present disclosure provides antibodies, including isolated monoclonal antibodies, which specifically bind to the Ephrin type-A receptor 10 with high affinity. Nucleic acid molecules encoding the Ephrin type-A receptor 10 antibodies, expression vectors, host cells and methods for expressing the Ephrin type-A receptor 10 antibodies are also provided. Bispecific molecules and pharmaceutical compositions comprising the Ephrin type-A receptor 10 antibodies are also provided. Methods for detecting the Ephrin type-A receptor 10, as well as methods for treating various cancers, including bladder cancer, breast cancer, colorectal cancer, head and neck cancer, kidney cancer, lung cancer, uterine cancer and pancreatic cancer are disclosed.

    摘要翻译： 本公开提供了以高亲和力特异性结合Ephrin-A型受体10的抗体，包括分离的单克隆抗体。 还提供了编码Ephrin-A型受体10抗体的核酸分子，表达载体，宿主细胞和表达Ephrin-A型受体10抗体的方法。 还提供了包含Ephrin-A型受体10抗体的双特异性分子和药物组合物。 公开了用于检测Ephrin A型受体10的方法，以及用于治疗各种癌症的方法，包括膀胱癌，乳腺癌，结肠直肠癌，头颈癌，肾癌，肺癌，子宫癌和胰腺癌。

    Human monoclonal antibodies to protein tyrosine kinase 7 (PTK7) and methods for using anti-PTK7 antibodies
    3.
    发明授权
    Human monoclonal antibodies to protein tyrosine kinase 7 (PTK7) and methods for using anti-PTK7 antibodies 有权
    蛋白酪氨酸激酶7（PTK7）的人单克隆抗体和使用抗PTK7抗体的方法

    公开(公告)号：US08222375B2

    公开(公告)日：2012-07-17

    申请号：US12095986

    申请日：2006-12-08

    申请人： Jonathan Alexander Terrett ,  Li-Sheng Lu ,  Chin Pan

    发明人： Jonathan Alexander Terrett ,  Li-Sheng Lu ,  Chin Pan

    IPC分类号： C07K16/40 ,  C07K16/00 ,  A61K39/395

    CPC分类号： C07K16/30 ,  A61K2039/505 ,  C07K16/40 ,  C07K2317/21 ,  C07K2317/565 ,  C07K2317/77

    摘要： The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to PTK7 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for detecting PTK7, as well as methods for treating various diseases, including cancer and infectious diseases, using anti-PTK7 antibodies.

    摘要翻译： 本发明提供了以高亲和力特异性结合PTK7的分离的单克隆抗体，特别是人单克隆抗体。 还提供了编码本发明抗体的核酸分子，表达载体，宿主细胞和用于表达本发明的抗体的方法。 还提供了免疫偶联物，双特异性分子和包含本发明抗体的药物组合物。 本发明还提供用于检测PTK7的方法，以及使用抗PTK7抗体治疗各种疾病（包括癌症和感染性疾病）的方法。

    Diagnosis of carcinoma using RAIG1 polypeptides
    7.
    发明申请
    Diagnosis of carcinoma using RAIG1 polypeptides 审中-公开
    使用RAIG1多肽诊断癌

    公开(公告)号：US20090258019A1

    公开(公告)日：2009-10-15

    申请号：US11986786

    申请日：2007-11-26

    申请人： Jonathan Alexander Terrett

    发明人： Jonathan Alexander Terrett

    IPC分类号： A61K39/395 ,  C12Q1/68 ,  G01N33/574 ,  C07K16/18 ,  A61P35/00

    CPC分类号： G01N33/57484 ,  G01N2500/00 ,  G01N2800/52

    摘要： The present invention relates to the new uses of a polypeptide (retinoic acid-inducible gene 1; RAIG1, also known as hypothetical protein FLJ10899 or retinoic acid induced 3) compositions comprising the polypeptide, including vaccines, antibodies that are immunospecific for the polypeptide and agents which interact with or modulate the expression or activity of the polypeptide or the expression of the nucleic acid which encodes the polypeptide. The use of the polypeptide in the diagnosis, screening and treatment of carcinoma, e.g. breast cancer, pancreatic cancer, lung cancer, liver cancer, ovarian cancer, colon cancer and/or osteosarcoma, is also provided.

    摘要翻译： 本发明涉及包含多肽的多肽（视黄酸诱导基因1; RAIG1，也称为假想蛋白FLJ10899或视黄酸诱导的3）的组合物的新用途，所述组合物包括疫苗，针对多肽和试剂具有免疫特异性的抗体 其与多肽的表达或活性相互作用或调节，或编码多肽的核酸的表达。 多肽在诊断，筛选和治疗癌症中的用途，例如 还提供了乳腺癌，胰腺癌，肺癌，肝癌，卵巢癌，结肠癌和/或骨肉瘤。