Invention Grant
US08227217B2 Methods and genetically engineered micro-organisms for the combined production of PDO, BDO and PHP by fermentation
有权
方法和遗传工程微生物通过发酵联合生产PDO，BDO和PHP
- Patent Title: Methods and genetically engineered micro-organisms for the combined production of PDO, BDO and PHP by fermentation
- Patent Title (中): 方法和遗传工程微生物通过发酵联合生产PDO，BDO和PHP
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Application No.: US12620142Application Date: 2009-11-17
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Publication No.: US08227217B2Publication Date: 2012-07-24
- Inventor: Dehua Liu , Hongjuan Liu , Xianjin Ou , Yan Sun , Yunzhen Xu , Yueyong Lei , Weibin Liu
- Applicant: Dehua Liu , Hongjuan Liu , Xianjin Ou , Yan Sun , Yunzhen Xu , Yueyong Lei , Weibin Liu
- Applicant Address: CN Beijing CN Yiyang
- Assignee: Tsinghua University,Hunan Rivers Biotechnology Co. Ltd.
- Current Assignee: Tsinghua University,Hunan Rivers Biotechnology Co. Ltd.
- Current Assignee Address: CN Beijing CN Yiyang
- Agency: Heslin Rothenberg Farley & Mesiti P.C.
- Main IPC: C12P7/42
- IPC: C12P7/42 ; C12P7/18 ; C12N9/00 ; C12N15/00
Abstract:
The present invention relates to genetically engineered micro-organisms for the combined production of 1,3-propanediol (PDO), 2,3-butanediol (BDO), and polyhydroxypropionic acid (PHP) by fermentation. In particular, the invention relates to a genetically engineered micro-organism suitable for combined production of PDO, BDO and PHP by fermentation, characterized in that: compared with corresponding wild-type starting micro-organism, the D-lactate dehydrogenase gene in the genetically engineered micro-organism is deleted or functionally inactivated, and the genetically engineered micro-organism comprises a heterogenous polynucleotide encoding the Coenzyme A-dependent Aldehyde dehydrogenase and a heterogenous polynucleotide encoding the Polyhydroxyalkanoate synthase. Methods for the construction of such micro-organisms, and methods for combined production of PDO, BDO and PHP by fermentation of a genetically engineered bacterium are also taught.
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