发明授权
- 专利标题: Drug condensation aerosols and kits
- 专利标题(中): 药物冷凝气溶胶和试剂盒
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申请号: US12117737申请日: 2008-05-08
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公开(公告)号: US08235037B2公开(公告)日: 2012-08-07
- 发明人: Ron L. Hale , Craig C. Hodges , Peter M. Lloyd , Amy T. Lu , Daniel J. Myers , Joshua D. Rabinowitz , Martin J. Wensley , Jeffrey A. McKinney , Alejandro C. Zaffaroni
- 申请人: Ron L. Hale , Craig C. Hodges , Peter M. Lloyd , Amy T. Lu , Daniel J. Myers , Joshua D. Rabinowitz , Martin J. Wensley , Jeffrey A. McKinney , Alejandro C. Zaffaroni
- 申请人地址: US CA Mountain View
- 专利权人: Alexza Pharmaceuticals, Inc.
- 当前专利权人: Alexza Pharmaceuticals, Inc.
- 当前专利权人地址: US CA Mountain View
- 代理机构: Swanson & Bratschun, L.L.C.
- 主分类号: A61M15/00
- IPC分类号: A61M15/00 ; A61K9/12 ; A61K9/14 ; H05B3/00
摘要:
The present invention provides novel condensation aerosols for the treatment of disease and/or intermittent or acute conditions. These condensation aerosols have little or no pyrolysis degradation products and are characterized by having an MMAD of between 1-3 microns. These aerosols are made by rapidly heating a substrate coated with a thin film of drug having a thickness of between 0.05 and 20 μm, while passing a gas over the film, to form particles of a desirable particle size for inhalation. Kits comprising a drug and a device for producing a condensation aerosol are also provided. The device contained in the kit typically, has an element for heating the drug which is coated as a film on the substrate and contains a therapeutically effective dose of a drug when the drug is administered in aerosol form, and an element allowing the vapor to cool to form an aerosol. Also disclosed, are methods for using these aerosols and kits.
公开/授权文献
- US20080311176A1 Drug Condensation Aerosols And Kits 公开/授权日:2008-12-18
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