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    Respiratory Drug Condensation Aerosols and Methods of Making and Using Them
    2.
    发明申请
    Respiratory Drug Condensation Aerosols and Methods of Making and Using Them 有权
    呼吸药物冷凝气溶胶及其使用方法

    公开(公告)号：US20090258075A1

    公开(公告)日：2009-10-15

    申请号：US12490102

    申请日：2009-06-23

    申请人： Ron L. Hale ,  Peter M. Lloyd ,  Amy T. Lu ,  Joshua D. Rabinowitz ,  Martin J. Wensley

    发明人： Ron L. Hale ,  Peter M. Lloyd ,  Amy T. Lu ,  Joshua D. Rabinowitz ,  Martin J. Wensley

    IPC分类号： A61K31/137 ,  A61K9/14 ,  A61K31/58 ,  A61K31/56 ,  A61K31/522

    CPC分类号： A61K9/0073 ,  A61K9/007 ,  A61K31/522 ,  A61K31/573 ,  Y10S514/958

    摘要： Described herein are respiratory drug condensation aerosols and methods of making and using them. Kits for delivering condensation aerosols are also described. The respiratory drug aerosols typically comprise respiratory drug condensation aerosol particles. In some variations the respiratory drug compound is selected from the group consisting of β-adrenergics, methylxanthines, anticholinergics, corticosteroids, mediator-release inhibitors, anti-leukotriene drugs, asthma inhibitors, asthma antagonists, anti-endothelin drugs, prostacyclin drugs, ion channel or pump inhibitors, enhancers, or modulators and pharmaceutically acceptable analogs, derivatives, and mixtures thereof. Methods of treating a respiratory ailment using the described aerosols are also described. In general, the methods typically comprise the step of administering a therapeutically effective amount of respiratory drug condensation aerosol to a person with a respiratory ailment. Methods of forming a respiratory drug condensation aerosol are also described. The methods comprise the steps of vaporizing and condensing a respiratory drug composition.

    摘要翻译： 本文描述的是呼吸药物冷凝气溶胶及其制备和使用方法。 还描述了用于输送冷凝气溶胶的试剂盒。 呼吸药物气溶胶通常包括呼吸药物凝结气溶胶颗粒。 在一些变化中，呼吸药物化合物选自β-肾上腺素能药，甲基黄嘌呤，抗胆碱能药，皮质类固醇，介质释放抑制剂，抗白三烯药物，哮喘抑制剂，哮喘拮抗剂，抗内皮素药物，前列环素药物，离子通道 或泵抑制剂，增强剂或调节剂及其药学上可接受的类似物，衍生物及其混合物。 还描述了使用所述气溶胶治疗呼吸道疾病的方法。 通常，所述方法通常包括向具有呼吸道疾病的人施用治疗有效量的呼吸药物冷凝气雾剂的步骤。 还描述了形成呼吸药物冷凝气溶胶的方法。 该方法包括蒸发和冷凝呼吸药物组合物的步骤。

    Method Of Forming An Aerosol For Inhalation Delivery
    3.
    发明申请
    Method Of Forming An Aerosol For Inhalation Delivery 有权
    形成用于吸入输送的气雾剂的方法

    公开(公告)号：US20090229600A1

    公开(公告)日：2009-09-17

    申请号：US12471070

    申请日：2009-05-22

    申请人： Ron L. Hale ,  Craig C. Hodges ,  Peter M. Lloyd ,  Daniel Mufson ,  Daniel D. Rogers ,  Soonho Song ,  Martin J. Wensley ,  Daniel J. Myers ,  Jeffrey A. McKinney ,  Reynaldo J. Quintana ,  Joshua D. Rabinowitz

    发明人： Ron L. Hale ,  Craig C. Hodges ,  Peter M. Lloyd ,  Daniel Mufson ,  Daniel D. Rogers ,  Soonho Song ,  Martin J. Wensley ,  Daniel J. Myers ,  Jeffrey A. McKinney ,  Reynaldo J. Quintana ,  Joshua D. Rabinowitz

    IPC分类号： A61M11/00

    CPC分类号： A61M11/044 ,  A61K9/007 ,  A61K9/0073 ,  A61K31/235 ,  A61K31/4468 ,  A61K31/485 ,  A61K31/519 ,  A61M11/001 ,  A61M11/02 ,  A61M15/00 ,  A61M15/0028 ,  A61M16/109 ,  A61M2016/0039 ,  A61M2205/3606 ,  A61M2205/3653 ,  A61M2205/368 ,  A61M2205/50 ,  B05B7/1686 ,  B05B17/04

    摘要： The present invention relates to the inhalation delivery of aerosols containing small particles. Specifically, it relates to a method of forming an aerosol for use in inhalation therapy. In a method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided. The method involves the following steps: (a) heating a substrate coated with a composition comprising a drug at a rate greater than 1000° C./s, thereby forming an vapor; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy. In another method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided. The method involves the following steps: (a) heating a substrate coated with a composition comprising a drug to form a vapor, wherein the coated composition is in the form of a film less than 10μ thick; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy. In another method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided. The method involves the following steps: (a) heating a substrate coated with a composition comprising a drug to form a vapor in less than 100 milliseconds, wherein the vapor has a mass greater than 0.1 mg; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy

    摘要翻译： 本发明涉及含有小颗粒的气溶胶的吸入输送。 具体地说，本发明涉及形成用于吸入治疗的气雾剂的方法。 在本发明的方法方面，提供了一种形成用于吸入治疗的气雾剂的方法。 该方法包括以下步骤：（a）以大于1000℃/ s的速率加热涂覆有包含药物的组合物的基底，从而形成蒸气; 和（b）允许蒸汽冷却，从而形成用于吸入治疗的气溶胶。 在本发明的另一方法方面，提供了形成用于吸入治疗的气雾剂的方法。 该方法包括以下步骤：（a）加热涂覆有包含药物的组合物的基底以形成蒸气，其中涂覆的组合物为小于10μm厚的膜的形式; 和（b）允许蒸汽冷却，从而形成用于吸入治疗的气溶胶。 在本发明的另一方法方面，提供了形成用于吸入治疗的气雾剂的方法。 该方法包括以下步骤：（a）加热涂覆有包含药物的组合物的基底以在小于100毫秒内形成蒸气，其中蒸气的质量大于0.1mg; 和（b）允许蒸汽冷却，从而形成用于吸入治疗的气溶胶

    Device for aerosolizing narcotics
    5.
    发明授权
    Device for aerosolizing narcotics 失效
    用于喷雾麻醉剂的装置

    公开(公告)号：US6098620A

    公开(公告)日：2000-08-08

    申请号：US549341

    申请日：1995-10-27

    申请人： Lester J. Lloyd ,  Peter M. Lloyd ,  Reid M. Rubsamen ,  Jeffrey A. Schuster

    发明人： Lester J. Lloyd ,  Peter M. Lloyd ,  Reid M. Rubsamen ,  Jeffrey A. Schuster

    IPC分类号： A61M5/14 ,  A61M15/00 ,  A61M16/00 ,  A61M16/14

    CPC分类号： A61M15/00 ,  A61M11/001 ,  A61M15/0045 ,  A61M15/0048 ,  A61M15/0051 ,  A61M15/008 ,  A61M16/142 ,  A61M15/009 ,  A61M2005/1405 ,  A61M2016/0021 ,  A61M2016/0039 ,  A61M2205/8206

    摘要： Devices, packaging and methodology for efficiently and repeatably creating aerosolized bursts of an analgesic (e.g., narcotic) containing formulation are disclosed. Devices are hand-held, self-contained units which are automatically actuated at the same release point in a patient's inspiratory flow cycle. The release point is automatically determined either mechanically or, more preferably calculated by a microprocessor which receives data from a sensor making it possible to determine inspiratory flow rate and inspiratory volume. The device is loaded with a cassette comprised of an outer housing which holds a package of individual disposable collapsible containers of an analgesic containing formulation for systemic delivery. Actuation of the device forces analgesic formulation through a porous membrane of the container which membrane has pores having a diameter in the range of about 0.25 to 3.0 microns, preferably 0.25 to 1.5 microns. The porous membrane is positioned in alignment with a surface of a channel through which a patient inhales air. The flow profile of air moving through the channel is such that the flow at the surface of the channel is less than the flow rate at the center of the channel.

    摘要翻译： 公开了用于有效和可重复地产生含有止痛剂（例如麻醉剂）的制剂的气雾化爆发的装置，包装和方法。 设备是手持式，独立的单元，在患者的吸气流循环中在相同的释放点自动启动。 释放点自动地被机械地确定，或者更优选地由接收来自传感器的数据的微处理器来计算，从而可以确定吸气流速和吸气体积。 该装置装载有由外壳构成的盒，该外壳保持包含用于系统递送的含镇痛剂的制剂的单个一次性可折叠容器的包装。 装置的致动通过容器的多孔膜来促使镇痛剂配方具有直径在约0.25至3.0微米范围内，优选0.25至1.5微米范围内的孔。 多孔膜定位成与患者吸入空气的通道的表面对准。 通过通道移动的空气的流动分布使得通道表面处的流量小于通道中心处的流量。

    Dynamic particle size control for aerosolized drug delivery
    7.
    发明授权
    Dynamic particle size control for aerosolized drug delivery 失效
    用于雾化药物递送的动态粒度控制

    公开(公告)号：US5522385A

    公开(公告)日：1996-06-04

    申请号：US313461

    申请日：1994-09-27

    申请人： Lester J. Lloyd ,  Peter M. Lloyd ,  Reid M. Rubsamen ,  Jeffrey A. Schuster

    发明人： Lester J. Lloyd ,  Peter M. Lloyd ,  Reid M. Rubsamen ,  Jeffrey A. Schuster

    IPC分类号： A61M11/00 ,  A61J7/04 ,  A61M11/04 ,  A61M15/00 ,  A61M16/00 ,  A61M16/10

    CPC分类号： A61M15/0045 ,  A61M11/001 ,  A61M11/005 ,  A61M11/042 ,  A61M15/0051 ,  A61M15/008 ,  A61M16/108 ,  A61J7/0445 ,  A61M15/0085 ,  A61M2016/0021 ,  A61M2016/0039 ,  A61M2205/52

    摘要： A device is provided which creates aerosolized particles by forcing a formulation of drug in a carrier through a nozzle (which nozzle may be in the form of a porous membrane) into a channel to a patient for inhalation. While in the channel energy is added to the particles in an amount sufficient to evaporate carrier and thereby reduce particle size. The amount of energy added can be adjusted depending on factors such as the particle size, the amount of the carrier to be evaporated, the water vapor content of the surrounding air and the composition of the carrier. Energy may be added in an amount sufficient to evaporate all carrier and thereby provide particles of dry powdered drug to patient which particles are uniform in size regardless of the surrounding humidity and smaller due to the evaporation of the carrier. Air drawn into the device by the patient may be drawn through a desiccator containing a desiccant which removes moisture from the air thereby improving evaporation efficiency when the carrier is water. Alternatively, water vapor may be introduced to the channel to saturate inhaled air thereby preventing evaporation of carrier and maintaining uniform particle size.

    摘要翻译： 提供了一种装置，其通过将药物在载体中的制剂通过喷嘴（该喷嘴可以是多孔膜的形式）施加到用于吸入的患者的通道中而产生雾化颗粒。 在通道中，能量以足以蒸发载体的量添加到颗粒中，从而减小粒径。 可以根据粒径，待蒸发的载体的量，周围空气的水蒸汽含量和载体的组成等因素调节能量的添加量。 可以以足以蒸发所有载体的量添加能量，从而向患者提供颗粒物质均匀的颗粒，而不管周围的湿度如何，并且由于载体的蒸发而更小。 由患者吸入装置的空气可以通过含有干燥剂的干燥器被吸入，干燥剂从空气中除去水分，从而当载体是水时提高蒸发效率。 或者，可以将水蒸汽引入通道以使吸入空气饱和，从而防止载体的蒸发并保持均匀的粒度。

    Respiratory drug condensation aerosols and methods of making and using them
    9.
    发明授权
    Respiratory drug condensation aerosols and methods of making and using them 有权

    公开(公告)号：US08506935B2

    公开(公告)日：2013-08-13

    申请号：US12490102

    申请日：2009-06-23

    申请人： Ron L. Hale ,  Peter M. Lloyd ,  Amy T. Lu ,  Joshua D. Rabinowitz ,  Martin J. Wensley

    发明人： Ron L. Hale ,  Peter M. Lloyd ,  Amy T. Lu ,  Joshua D. Rabinowitz ,  Martin J. Wensley

    IPC分类号： A61K9/12 ,  A61K9/14 ,  A61M15/00 ,  H05B3/00

    CPC分类号： A61K9/0073 ,  A61K9/007 ,  A61K31/522 ,  A61K31/573 ,  Y10S514/958

    摘要： Described herein are respiratory drug condensation aerosols and methods of making and using them. Kits for delivering condensation aerosols are also described. The respiratory drug aerosols typically comprise respiratory drug condensation aerosol particles. In some variations the respiratory drug compound is selected from the group consisting of β-adrenergics, methylxanthines, anticholinergics, corticosteroids, mediator-release inhibitors, anti-leukotriene drugs, asthma inhibitors, asthma antagonists, anti-endothelin drugs, prostacyclin drugs, ion channel or pump inhibitors, enhancers, or modulators and pharmaceutically acceptable analogs, derivatives, and mixtures thereof. Methods of treating a respiratory ailment using the described aerosols are also described. In general, the methods typically comprise the step of administering a therapeutically effective amount of respiratory drug condensation aerosol to a person with a respiratory ailment. Methods of forming a respiratory drug condensation aerosol are also described. The methods comprise the steps of vaporizing and condensing a respiratory drug composition.

    Inhalation device for producing a drug aerosol
    10.
    发明授权
    Inhalation device for producing a drug aerosol 有权
    用于生产药物气溶胶的吸入装置

    公开(公告)号：US07913688B2

    公开(公告)日：2011-03-29

    申请号：US10442385

    申请日：2003-05-20

    申请人： Stephen Cross ,  Craig C. Hodges ,  Ron L. Hale ,  Peter M. Lloyd ,  Daniel J. Myers ,  Reynaldo J. Quintana ,  Joshua D. Rabinowitz ,  Curtis Tom ,  Martin J. Wensley

    发明人： Stephen Cross ,  Craig C. Hodges ,  Ron L. Hale ,  Peter M. Lloyd ,  Daniel J. Myers ,  Reynaldo J. Quintana ,  Joshua D. Rabinowitz ,  Curtis Tom ,  Martin J. Wensley

    IPC分类号： A61M15/08 ,  F23D11/00 ,  F23D14/00

    CPC分类号： A61M15/00 ,  A61M11/002 ,  A61M11/041 ,  A61M11/042 ,  A61M11/047

    摘要： A device for delivering a drug by inhalation is disclosed. The device includes a body defining an interior flow-through chamber having upstream and downstream chamber openings, and a drug supply unit contained within the chamber for producing, upon actuation, a heated drug vapor in a condensation region of the chamber. Gas drawn through the chamber region at a selected gas-flow rate is effective to form drug condensation particles from the drug vapor having a selected MMAD between 0.02 and 0.1 MMAD or between 1 and 3.5 μm. A gas-flow control valve disposed upstream of the unit functions to limit gas-flow rate through the condensation region to the selected gas-flow rate. An actuation switch in the device activates the drug-supply unit, such that the drug-supply unit can be controlled to produce vapor when the gas-flow rate through the chamber is at the selected flow rate.

    摘要翻译： 公开了一种通过吸入传送药物的装置。 该装置包括限定具有上游和下游室开口的内部流通室的主体，以及容纳在该室内的药物供应单元，用于在致动时产生在该室的冷凝区域中的加热的药物蒸气。 以选定的气体流速通过室区域抽吸的气体有效地从具有0.02至0.1MMAD的选定MMAD或1至3.5μm之间的药物蒸气形成药物凝结颗粒。 设置在单元上游的气体流量控制阀用于将通过冷凝区域的气体流量限制到所选择的气体流量。 装置中的致动开关激活药物供应单元，使得当通过腔室的气体流量处于所选择的流速时，可以控制药物供应单元产生蒸汽。