Invention Grant
- Patent Title: Diarylether derivatives as antitumor agents
- Patent Title (中): 二元醚衍生物作为抗肿瘤剂
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Application No.: US12095930Application Date: 2006-12-04
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Publication No.: US08236826B2Publication Date: 2012-08-07
- Inventor: Hironori Matsuyama , Kenji Ohnishi , Takashi Nakagawa , Hideki Takasu , Makoto Sakamoto , Kumi Higuchi , Keisuke Miyajima , Satoshi Yamada , Masaaki Motoyama , Yutaka Kojima , Koichi Yasumura , Takeshi Kodama , Shun Otsuji , Keizo Kan , Takumi Sumida
- Applicant: Hironori Matsuyama , Kenji Ohnishi , Takashi Nakagawa , Hideki Takasu , Makoto Sakamoto , Kumi Higuchi , Keisuke Miyajima , Satoshi Yamada , Masaaki Motoyama , Yutaka Kojima , Koichi Yasumura , Takeshi Kodama , Shun Otsuji , Keizo Kan , Takumi Sumida
- Applicant Address: JP Tokyo
- Assignee: Otsuka Pharmaceutical Co., Ltd.
- Current Assignee: Otsuka Pharmaceutical Co., Ltd.
- Current Assignee Address: JP Tokyo
- Agency: Finnegan, Henderson, Farabow, Garrett & Dunner, L.L.P.
- Priority: JP2005-351255 20051205
- International Application: PCT/JP2006/324610 WO 20061204
- International Announcement: WO2007/066784 WO 20070614
- Main IPC: A61K31/44
- IPC: A61K31/44

Abstract:
An object of the present invention is to provide a medicinal drug much improved in anti tumor activity and excellent in safety. According to the present invention, there is provided a medicinal drug containing a compound represented by the following general formula (1) or a salt thereof as an active ingredient: [Formula 1] wherein X1 represents a nitrogen atom or a group —CH═, R1 represents a group —Z—R6, in which Z represents a group —CO—, a group —CH(OH)— or the like, R6 represents a 5- to 15-membered monocyclic, dicyclic or tricyclic saturated or unsaturated heterocyclic group having 1 to 4 nitrogen atoms, oxygen atoms or sulfur atoms, R2 represents a hydrogen atom or a halogen atom, Y represents a group —O—, a group —CO—, a group —CH(OH)— or a lower alkylene group, and A represents [Formula 2] wherein R3 represents a hydrogen atom, a lower alkoxy group or the like, p represents 1 or 2, R4 represents an imidazolyl lower alkyl group or the like.
Public/Granted literature
- US20100004438A1 DIARYLETHER DERIVATIVES AS ANTITUMOR AGENTS Public/Granted day:2010-01-07
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