公开(公告)号：US08551999B2

公开(公告)日：2013-10-08

申请号：US12740684

申请日：2008-10-29

申请人： Takumi Sumida ,  Fujio Tabusa ,  Kazuo Sekiguchi ,  Takeshi Kodama ,  Koichi Yasumura ,  Yutaka Kojima ,  Masaaki Motoyama ,  Keisuke Miyajima ,  Kenji Yoshida ,  Keizo Kan ,  Makoto Sakamoto ,  Hideki Takasu ,  Takashi Nakagawa ,  Naoto Ohi ,  Yasuo Harada ,  Norikazu Hashimoto ,  Hironori Matsuyama ,  Masatoshi Iida ,  Shigekazu Fujita ,  Tae Fukushima

发明人： Takumi Sumida ,  Fujio Tabusa ,  Kazuo Sekiguchi ,  Takeshi Kodama ,  Koichi Yasumura ,  Yutaka Kojima ,  Masaaki Motoyama ,  Keisuke Miyajima ,  Kenji Yoshida ,  Keizo Kan ,  Makoto Sakamoto ,  Hideki Takasu ,  Takashi Nakagawa ,  Naoto Ohi ,  Yasuo Harada ,  Norikazu Hashimoto ,  Hironori Matsuyama ,  Masatoshi Iida ,  Shigekazu Fujita ,  Tae Fukushima

IPC分类号： A61K31/496 ,  A61K31/454 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D417/14 ,  A61K31/506 ,  C07D403/12

CPC分类号： C07D401/12 ,  C07D403/12

摘要： The present invention provides a heterocyclic compound represented by General Formula (1): wherein R1 is a group R5—Z1—, etc., Z1 is a lower alkylene group, etc., and R5 is a group represented by General Formula; wherein R13 is a hydrogen atom, etc., m is an integer from 1 to 5; R2 is a hydrogen atom: Y is CH or N: A1 is a heterocyclic ring selected from the group consisting of indolediyl groups, wherein the heterocyclic ring may have at least one substituent: T is a group —CO—, etc.: R3 is a hydrogen atom, etc.: R4 is a lower alkyl group optionally substituted by one or more hydroxy groups, etc.: R3 and R4, together with the nitrogen atom to which they bind, may bind to each other and form a 5- to 10-membered saturated heterocyclic ring, wherein the heterocyclic ring may have at least one substituent. The heterocyclic compound of the present invention has excellent effects of suppressing the production of collagen and/or treating tumors.

摘要翻译： 本发明提供由通式（1）表示的杂环化合物：其中R1为R5-Z1-基团等，Z1为低级亚烷基等，R5为通式所示的基团。 其中R 13为氢原子等，m为1至5的整数; R2是氢原子：Y是CH或N：A1是选自吲哚二基的杂环，其中杂环可以具有至少一个取代基：T是-CO-等：R3是 氢原子等：R4是任选被一个或多个羟基取代的低级烷基等：R 3和R 4与它们所键合的氮原子一起可以彼此结合形成5- 10元饱和杂环，其中杂环可以具有至少一个取代基。 本发明的杂环化合物具有抑制胶原蛋白的生成和/或治疗肿瘤的优异效果。

公开(公告)号：US20050239319A1

公开(公告)日：2005-10-27

申请号：US11115508

申请日：2005-04-27

申请人： Hideki Takasu

发明人： Hideki Takasu

IPC分类号： H01R4/18 ,  H01R9/05 ,  H01R103/00 ,  H01R4/24

CPC分类号： H01R24/44 ,  H01R4/184 ,  H01R9/0518 ,  H01R2103/00

摘要： A coaxial connector, in which control of impedance is facilitated, and in which fluctuations in impedance are extremely small. The coaxial connector includes an inner contact, having a crimp connection portion which is crimped onto an inner conductor of a coaxial cable, an outer contact, which is crimped onto an outer conductor of the coaxial cable and an insulator (dielectric), which is provided between the inner contact and the outer contract. Concavities are formed in the outer surface of the dielectric at positions corresponding to the crimp connection portion of the inner contact The concavities control the characteristic impedance of the coaxial connector.

摘要翻译： 一种同轴连接器，其中阻抗的控制被促进，并且其中阻抗的波动非常小。 同轴连接器包括内接触件，其具有压接在同轴电缆的内导体上的压接连接部分，压接在同轴电缆的外导体上的外触点和绝缘体（电介质） 内部接触和外部合同之间。 在电介质的外表面形成凹部，该位置对应于内触头的压接连接部分。凹部控制同轴连接器的特性阻抗。

公开(公告)号：US20100004438A1

公开(公告)日：2010-01-07

申请号：US12095930

申请日：2006-12-04

申请人： Hironori Matsuyama ,  Kenji Ohnishi ,  Takashi Nakagawa ,  Hideki Takasu ,  Makoto Sakamoto ,  Kumi Higuchi ,  Keisuke Miyajima ,  Satoshi Yamada ,  Masaaki Motoyama ,  Yutaka Kojima ,  Koichi Yasumura ,  Takeshi Kodama ,  Shun Otsuji ,  Keizo Kan ,  Takumi Sumida

发明人： Hironori Matsuyama ,  Kenji Ohnishi ,  Takashi Nakagawa ,  Hideki Takasu ,  Makoto Sakamoto ,  Kumi Higuchi ,  Keisuke Miyajima ,  Satoshi Yamada ,  Masaaki Motoyama ,  Yutaka Kojima ,  Koichi Yasumura ,  Takeshi Kodama ,  Shun Otsuji ,  Keizo Kan ,  Takumi Sumida

IPC分类号： C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D401/12 ,  C07D295/155 ,  C07D211/56 ,  C07D213/72

CPC分类号： A61K31/496 ,  A61K31/495

摘要： An object of the present invention is to provide a medicinal drug much improved in anti tumor activity and excellent in safety. According to the present invention, there is provided a medicinal drug containing a compound represented by the following general formula (1) or a salt thereof as an active ingredient: [Formula 1] wherein X1 represents a nitrogen atom or a group —CH═, R1 represents a group -Z-R6, in which Z represents a group —CO—, a group —CH(OH)— or the like, R6 represents a 5- to 15-membered monocyclic, dicyclic or tricyclic saturated or unsaturated heterocyclic group having 1 to 4 nitrogen atoms, oxygen atoms or sulfur atoms, R2 represents a hydrogen atom or a halogen atom, Y represents a group —O—, a group —CO—, a group —CH(OH)— or a lower alkylene group, and A represents [Formula 2] wherein R3 represents a hydrogen atom, a lower alkoxy group or the like, p represents 1 or 2, R4 represents an imidazolyl lower alkyl group or the like.

摘要翻译： 本发明的目的在于提供一种抗肿瘤活性大大提高的安全性药物。 根据本发明，提供含有下述通式（1）表示的化合物或其盐作为有效成分的药物：[式1]其中X1表示氮原子或基团-CH-， R1表示基团-Z-R6，其中Z表示基团-CO-，基团-CH（OH） - 等，R6表示5至15元单环，二环或三环饱和或不饱和杂环基 具有1至4个氮原子，氧原子或硫原子，R 2表示氢原子或卤素原子，Y表示基团-O-，基团-CO-，基团-CH（OH） - 或低级亚烷基 A表示[式2]其中R3表示氢原子，低级烷氧基等，p表示1或2，R4表示咪唑基低级烷基等。

公开(公告)号：US20060022769A1

公开(公告)日：2006-02-02

申请号：US11206001

申请日：2005-08-18

申请人： Hideki Takasu

发明人： Hideki Takasu

IPC分类号： H01P1/18

CPC分类号： H01P1/184

摘要： A phase shifter according to this invention includes a circuit board having a semi-insulating layer. An active layer is formed in a transmission line forming portion on one surface side of the semi-insulating layer, a first ground conductive layer is formed on the other surface side, a transmission line is formed on the upper side of the active layer, and a second ground conductive layer is formed on the transmission line forming surface of the semi-insulating layer in close proximity to one side of the transmission line. If a bias voltage of negative polarity is applied to the transmission line, reverse bias is applied to the active layer to form a depletion layer and capacitance is equivalently connected to the transmission line having inductance. A phase shift amount can be freely controlled by changing the value of the capacitance according to the bias voltage.

摘要翻译： 根据本发明的移相器包括具有半绝缘层的电路板。 在半绝缘层的一个表面侧的传输线形成部分中形成有源层，在另一个表面侧形成第一接地导电层，在有源层的上侧形成传输线，并且 在半绝缘层的传输线形成表面上靠近传输线的一侧形成第二接地导电层。 如果将负极性的偏置电压施加到传输线，则向有源层施加反向偏置以形成耗尽层，并且电容等效地连接到具有电感的传输线。 可以通过根据偏置电压改变电容值来自由地控制相移量。

公开(公告)号：US06707678B2

公开(公告)日：2004-03-16

申请号：US10132297

申请日：2002-04-26

申请人： Toshiki Kobayashi ,  Keiichi Kato ,  Hideki Takasu ,  Toshio Fujimura

发明人： Toshiki Kobayashi ,  Keiichi Kato ,  Hideki Takasu ,  Toshio Fujimura

IPC分类号： H05K500

CPC分类号： H05K5/062 ,  H05K5/0052

摘要： A casing for an electronic control device, by which a cover and a casing body are reliably sealed up while preventing the cover from warping or from being distorted, although the cover is made of a thin sheet material. The electronic control device casing comprises: a casing body having an opening in its upper face portion for casing a printed circuit board; a cover made of a sheet material for closing the opening of the casing body; a groove portion formed in the open edge portion of the casing body; a liquid sealing material fitted in the groove portion for sealing the open edge portion of the casing body and the flange portion of the cover; and a ridge portion having a generally U-shaped section and formed on the flange portion of the cover for being fitted in the groove portion of the casing body.

摘要翻译： 另外，电子控制装置用壳体虽然是由薄片材料构成，但也可以将盖体和壳体主体可靠地密封起来，同时防止盖翘曲或翘曲变形。 电子控制装置壳体包括：壳体，其在其上表面部分具有用于封装印刷电路板的开口; 由用于封闭壳体的开口的片状材料制成的盖; 形成在所述壳体的开口边缘部的槽部; 装配在槽部中用于密封壳体的开口边缘部分和盖的凸缘部分的液体密封材料; 以及具有大致U形截面并形成在所述盖的所述凸缘部分上以嵌入所述壳体的所述槽部中的脊部。

公开(公告)号：US06407925B1

公开(公告)日：2002-06-18

申请号：US09662921

申请日：2000-09-15

申请人： Toshiki Kobayashi ,  Keiichi Kato ,  Hideki Takasu ,  Toshio Fujimura

发明人： Toshiki Kobayashi ,  Keiichi Kato ,  Hideki Takasu ,  Toshio Fujimura

IPC分类号： H05K500

CPC分类号： H05K5/062 ,  H05K5/0052

摘要： A casing for an electronic control device, by which a cover and a casing body are reliably sealed up while preventing the cover from warping or from being distorted, although the cover is made of a thin sheet material. The electronic control device casing comprises: a casing body having an opening in its upper face portion for casing a printed circuit board; a cover made of a sheet material for closing the opening of the casing body; a groove portion formed in the open edge portion of the casing body; a liquid sealing material fitted in the groove portion for sealing the open edge portion of the casing body and the flange portion of the cover; and a ridge portion having a generally U-shaped section and formed on the flange portion of the cover for being fitted in the groove portion of the casing body.

摘要翻译： 另外，电子控制装置用壳体虽然是由薄片材料构成，但也可以将盖体和壳体主体可靠地密封起来，同时防止盖翘曲或翘曲变形。 电子控制装置壳体包括：壳体，其在其上表面部分具有用于封装印刷电路板的开口; 由用于封闭壳体的开口的片状材料制成的盖; 形成在所述壳体的开口边缘部的槽部; 装配在槽部中用于密封壳体的开口边缘部分和盖的凸缘部分的液体密封材料; 以及具有大致U形截面并形成在所述盖的所述凸缘部分上以嵌入所述壳体的所述槽部中的脊部。

公开(公告)号：US20120238750A1

公开(公告)日：2012-09-20

申请号：US13409090

申请日：2012-02-29

申请人： Tae FUKUSHIMA ,  Shuji Matsumura ,  Noriaki Takemura ,  Hideaki Satou ,  Nobuaki Ito ,  Takuya Shitsuta ,  Hironori Tsutsui ,  Michinori Tanaka ,  Keizo Kan ,  Hitoshi Nagao ,  Kenji Watanabe ,  Kuninori Tai ,  Takashi Nakagawa ,  Hideki Takasu ,  Makoto Sakamoto ,  Keisuke Miyajima ,  Satoshi Yamada ,  Yutaka Kojima ,  Koichi Yasumura ,  Naoto Ohi ,  Mitsuhiro Okuno ,  Kazuhisa Sugiyama ,  Kunihiko Kiyono ,  Takashi Suzuki ,  Seiji Akamatsu ,  Takeshi Kodama ,  Yasuo Yanagihara ,  Takumi Sumida

发明人： Tae FUKUSHIMA ,  Shuji Matsumura ,  Noriaki Takemura ,  Hideaki Satou ,  Nobuaki Ito ,  Takuya Shitsuta ,  Hironori Tsutsui ,  Michinori Tanaka ,  Keizo Kan ,  Hitoshi Nagao ,  Kenji Watanabe ,  Kuninori Tai ,  Takashi Nakagawa ,  Hideki Takasu ,  Makoto Sakamoto ,  Keisuke Miyajima ,  Satoshi Yamada ,  Yutaka Kojima ,  Koichi Yasumura ,  Naoto Ohi ,  Mitsuhiro Okuno ,  Kazuhisa Sugiyama ,  Kunihiko Kiyono ,  Takashi Suzuki ,  Seiji Akamatsu ,  Takeshi Kodama ,  Yasuo Yanagihara ,  Takumi Sumida

IPC分类号： C07D401/12 ,  C07D413/14 ,  C07D211/46 ,  C07D295/155 ,  C07D405/14

CPC分类号： C07C229/18 ,  C07C205/38 ,  C07C217/90 ,  C07C233/45 ,  C07C233/75 ,  C07C271/58 ,  C07C275/34 ,  C07C2601/02 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2601/18 ,  C07D211/46 ,  C07D211/58 ,  C07D211/62 ,  C07D211/70 ,  C07D213/75 ,  C07D239/42 ,  C07D241/20 ,  C07D295/185 ,  C07D295/192 ,  C07D317/58 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14

摘要： The compound of the present invention is represented by the following general formula (1): [wherein X1 represents a nitrogen atom or a group —CH═; R1 represents a group —Z—R6, wherein Z represents a group —CO—, a group —CH(OH)—, or the like, and R6 represents a 5- to 15-membered monocyclic, dicyclic, or tricyclic, saturated or unsaturated heterocyclic group having 1 to 4 nitrogen atoms, oxygen atoms, or sulfur atoms; R2 represents a hydrogen atom, a halogen atom or a lower alkylene group; Y represents a group —O—, a group —CO—, a group —CH(OH)—, a lower alkylene group, or the like; and A represents a group or the like, wherein R3 represents a hydrogen atom, a lower alkoxy group, or the like, p represents 1 or 2, and R4 represents an imidazolyl lower alkyl group or the like.

摘要翻译： 本发明的化合物由以下通式（1）表示：[其中X 1表示氮原子或-CH =; R1表示基团-Z-R6，其中Z表示基团-CO-，基团-CH（OH） - 等，R6表示5至15元单环，双环或三环饱和或 具有1-4个氮原子的不饱和杂环基，氧原子或硫原子; R2表示氢原子，卤素原子或低级亚烷基; Y表示基团-O-，基团-CO-，基团-CH（OH） - ，低级亚烷基基团等; A表示基团等，其中R3表示氢原子，低级烷氧基等，p表示1或2，R4表示咪唑基低级烷基等。

公开(公告)号：US5435756A

公开(公告)日：1995-07-25

申请号：US274057

申请日：1994-07-12

申请人： Hideki Takasu

发明人： Hideki Takasu

IPC分类号： H01R9/05 ,  H01R13/40 ,  H01R17/04

CPC分类号： H01R9/0518 ,  H01R24/542 ,  H01R2103/00 ,  H01R9/035

摘要： One end of a two-core twisted pair cable 30 having two twisted wires 32 and 34 in a common jacket 36 is prepared. An insert 20 having a pair of semicylindrical halves 22a and 22b connected by a hinge 21 in which a central groove 25 and a branched groove 26 are formed is used. An insert subassembly is prepared by placing one wire 32 connected to the central contact in the central groove 25 of the insert 20, and by placing the other wire 34 in the branched groove 26 and bringing outside its exposed conductor 38. This insert subassembly is inserted in the outer ferrule 13 of the metal shell 12 of the BNC connector 10, after which the ferrule is crimped, thus connecting the conductor 38 to the metal shell 12.

摘要翻译： 制备在公共护套36中具有两条绞合线32和34的双芯双绞线电缆30的一端。 使用具有通过铰链21连接的一对半圆柱半部22a和22b的插入件20，其中形成有中心槽25和分支槽26。 通过将连接到中心触点的一个线32放置在插入件20的中心凹槽25中，并且将另一个线34放置在分支槽26中并且将其外露在其暴露的导体38之外来准备插入子组件。该插入子组件被插入 在BNC连接器10的金属外壳12的外套圈13中，之后套圈被压接，从而将导体38连接到金属壳12。

公开(公告)号：US08188277B2

公开(公告)日：2012-05-29

申请号：US11659689

申请日：2005-08-03

申请人： Tae Fukushima ,  Shuji Matsumura ,  Noriaki Takemura ,  Hideaki Satou ,  Nobuaki Ito ,  Takuya Shitsuta ,  Hironori Tsutsui ,  Michinori Tanaka ,  Keizo Kan ,  Hitoshi Nagao ,  Kenji Watanabe ,  Kuninori Tai ,  Takashi Nakagawa ,  Hideki Takasu ,  Makoto Sakamoto ,  Keisuke Miyajima ,  Satoshi Yamada ,  Yutaka Kojima ,  Koichi Yasumura ,  Naoto Ohi ,  Mitsuhiro Okuno ,  Kazuhisa Sugiyama ,  Kunihiko Kiyono ,  Takashi Suzuki ,  Seiji Akamatsu ,  Takeshi Kodama ,  Yasuo Yanagihara ,  Takumi Sumida

发明人： Tae Fukushima ,  Shuji Matsumura ,  Noriaki Takemura ,  Hideaki Satou ,  Nobuaki Ito ,  Takuya Shitsuta ,  Hironori Tsutsui ,  Michinori Tanaka ,  Keizo Kan ,  Hitoshi Nagao ,  Kenji Watanabe ,  Kuninori Tai ,  Takashi Nakagawa ,  Hideki Takasu ,  Makoto Sakamoto ,  Keisuke Miyajima ,  Satoshi Yamada ,  Yutaka Kojima ,  Koichi Yasumura ,  Naoto Ohi ,  Mitsuhiro Okuno ,  Kazuhisa Sugiyama ,  Kunihiko Kiyono ,  Takashi Suzuki ,  Seiji Akamatsu ,  Takeshi Kodama ,  Yasuo Yanagihara ,  Takumi Sumida

IPC分类号： C07D241/36 ,  C07D413/12 ,  C07D403/12 ,  C07D221/02 ,  C07D401/12 ,  C07D213/62 ,  A61K31/535 ,  A61K31/497 ,  A61K31/445

CPC分类号： C07C229/18 ,  C07C205/38 ,  C07C217/90 ,  C07C233/45 ,  C07C233/75 ,  C07C271/58 ,  C07C275/34 ,  C07C2601/02 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2601/18 ,  C07D211/46 ,  C07D211/58 ,  C07D211/62 ,  C07D211/70 ,  C07D213/75 ,  C07D239/42 ,  C07D241/20 ,  C07D295/185 ,  C07D295/192 ,  C07D317/58 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14

摘要： The present invention provides a novel compound, which has an excellent effect of suppressing the generation of collagen and less side effects, with being excellent in terms of safety. The compound of the present invention is represented by the following general formula (1): [wherein X1 represents a nitrogen atom or a group —CH═; R1 represents a group —Z—R6, wherein Z represents a group —CO—, a group —CH(OH)—, or the like, and R6 represents a 5- to 15-membered monocyclic, dicyclic, or tricyclic, saturated or unsaturated heterocyclic group having 1 to 4 nitrogen atoms, oxygen atoms, or sulfur atoms; R2 represents a hydrogen atom, a halogen atom or a lower alkylene group; Y represents a group —O—, a group —CO—, a group —CH(OH)—, a lower alkylene group, or the like; and A represents a group or the like, wherein R3 represents a hydrogen atom, a lower alkoxy group, or the like, p represents 1 or 2, and R4 represents an imidazolyl lower alkyl group or the like.

摘要翻译： 本发明提供了一种新颖的化合物，其具有优异的抑制胶原产生的效果和较少的副作用。 本发明的化合物由以下通式（1）表示：[其中X 1表示氮原子或-CH =; R1表示基团-Z-R6，其中Z表示基团-CO-，基团-CH（OH） - 等，R6表示5至15元单环，双环或三环饱和或 具有1-4个氮原子的不饱和杂环基，氧原子或硫原子; R2表示氢原子，卤素原子或低级亚烷基; Y表示基团-O-，基团-CO-，基团-CH（OH） - ，低级亚烷基基团等; A表示基团等，其中R3表示氢原子，低级烷氧基等，p表示1或2，R4表示咪唑基低级烷基等。

公开(公告)号：US20070270422A1

公开(公告)日：2007-11-22

申请号：US11659689

申请日：2005-08-03

申请人： Tae Fukushima ,  Shuji Matsumura ,  Noriaki Takemura ,  Hideaki Satou ,  Nobuaki Ito ,  Takuya Shitsuta ,  Hironori Tsutsui ,  Michinori Tanaka ,  Keizo Kan ,  Hitoshi Nagao ,  Kenji Watanabe ,  Kuninori Tai ,  Takashi Nakagawa ,  Hideki Takasu ,  Makoto Sakamoto ,  Keisuke Miyajima ,  Satoshi Yamada ,  Yutaka Kojima ,  Koichi Yasumura ,  Naoto Ohi ,  Mitsuhiro Okuno ,  Kazuhisa Sugiyama ,  Kunihiko Kiyono ,  Takashi Suzuki ,  Seiji Akamatsu ,  Takeshi Kodama ,  Yasuo Yanagihara ,  Takumi Sumida

发明人： Tae Fukushima ,  Shuji Matsumura ,  Noriaki Takemura ,  Hideaki Satou ,  Nobuaki Ito ,  Takuya Shitsuta ,  Hironori Tsutsui ,  Michinori Tanaka ,  Keizo Kan ,  Hitoshi Nagao ,  Kenji Watanabe ,  Kuninori Tai ,  Takashi Nakagawa ,  Hideki Takasu ,  Makoto Sakamoto ,  Keisuke Miyajima ,  Satoshi Yamada ,  Yutaka Kojima ,  Koichi Yasumura ,  Naoto Ohi ,  Mitsuhiro Okuno ,  Kazuhisa Sugiyama ,  Kunihiko Kiyono ,  Takashi Suzuki ,  Seiji Akamatsu ,  Takeshi Kodama ,  Yasuo Yanagihara ,  Takumi Sumida

IPC分类号： C07D401/14 ,  A61K31/165 ,  A61K31/167 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/445 ,  A61K31/4523 ,  A61K31/495 ,  A61K31/496 ,  A61K31/5375 ,  A61K31/5377 ,  A61P11/00 ,  C07C233/00 ,  C07C233/92 ,  C07D211/00 ,  C07D211/40 ,  C07D211/56 ,  C07D241/04 ,  C07D413/14 ,  C07D413/02 ,  C07D241/36

CPC分类号： C07C229/18 ,  C07C205/38 ,  C07C217/90 ,  C07C233/45 ,  C07C233/75 ,  C07C271/58 ,  C07C275/34 ,  C07C2601/02 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2601/18 ,  C07D211/46 ,  C07D211/58 ,  C07D211/62 ,  C07D211/70 ,  C07D213/75 ,  C07D239/42 ,  C07D241/20 ,  C07D295/185 ,  C07D295/192 ,  C07D317/58 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14

摘要： The present invention provides a novel compound, which has an excellent effect of suppressing the generation of collagen and less side effects, with being excellent in terms of safety. The compound of the present invention is represented by the following general formula (1): [wherein X1 represents a nitrogen atom or a group —CH═; R1 represents a group -Z-R6, wherein Z represents a group —CO—, a group —CH(OH)—, or the like, and R6 represents a 5- to 15-membered monocyclic, dicyclic, or tricyclic, saturated or unsaturated heterocyclic group having 1 to 4 nitrogen atoms, oxygen atoms, or sulfur atoms; R2 represents a hydrogen atom, a halogen atom or a lower alkylene group; Y represents a group —O—, a group —CO—, a group —CH(OH)—, a lower alkylene group, or the like; and A represents a group or the like, wherein R3 represents a hydrogen atom, a lower alkoxy group, or the like, p represents 1 or 2, and R4 represents an imidazolyl lower alkyl group or the like.

摘要翻译： 本发明提供了一种新颖的化合物，其具有优异的抑制胶原产生的效果和较少的副作用。 本发明的化合物由以下通式（1）表示：[其中X 1表示氮原子或基团-CH-; R 1表示基团-ZR 6，其中Z表示-CO-基团，-CH（OH） - 基等基团，R“ 6表示具有1至4个氮原子，氧原子或硫原子的5至15元单环，二环或三环饱和或不饱和杂环基; R 2表示氢原子，卤素原子或低级亚烷基; Y表示基团-O-，基团-CO-，基团-CH（OH） - ，低级亚烷基基团等; A表示基团等，其中R 3表示氢原子，低级烷氧基等，p表示1或2，R 4表示 咪唑基低级烷基等。