发明授权
- 专利标题： Regulation of gene expression by protein methylation
- 专利标题（中）： 通过蛋白质甲基化调节基因表达
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申请号： US12573066申请日： 2009-10-02
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公开(公告)号： US08247168B2公开(公告)日： 2012-08-21
- 发明人: Michael R. Stallcup , Dagang Chen , Heng Hong , Dana W. Aswad
- 申请人： Michael R. Stallcup , Dagang Chen , Heng Hong , Dana W. Aswad
- 申请人地址： US CA Los Angeles US CA Oakland
- 专利权人： University of Southern California,The Regents of the University of California
- 当前专利权人： University of Southern California,The Regents of the University of California
- 当前专利权人地址： US CA Los Angeles US CA Oakland
- 代理机构： Foley & Lardner LLP
- 代理商 Antoinette F. Konski
- 主分类号： C12Q1/48
- IPC分类号： C12Q1/48 ; C12Q1/68 ; C12N9/10
摘要：
The invention relates to the cDNA and deduced amino acid sequence of the Coactivator Associated arginine (R) Methyltransferase protein, CARM1. A method is described for the use CARM1 to regulate gene expression in vivo. CARM1 has also been used to methylate arginine residues of histones, synthetic peptides, and other proteins. A method to use CARM1 to screen for drugs that inhibit its methyltransferase activity is also described, as is a method to screen for drugs that modulate CARM1's interactions with other proteins.
公开/授权文献
- US20100092982A1 Regulation of Gene Expression by Protein Methylation 公开/授权日：2010-04-15
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